{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T06:25:15Z","timestamp":1793773515182,"version":"4.6.1"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,11,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Surgical repair of supravalvar aortic stenosis (SVAS) provides excellent early outcomes; however, late reintervention remains common. The determinants of left ventricular outflow tract (LVOT) failure, particularly the role of residual haemodynamics, remain incompletely defined. We sought to identify predictors of LVOT reintervention in a contemporary cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective study of consecutive patients aged &amp;lt;18 years undergoing SVAS repair between 2005 and 2024 was performed. Primary end-points were overall survival and freedom from LVOT reintervention. Survival and freedom from reintervention were assessed using Kaplan-Meier analysis. Multivariable Cox regression was used to identify independent predictors of LVOT reintervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Seventy-seven patients underwent repair at a median age of 3 (1-8) years, with median follow-up of 9.3 (6-14) years. There was no early or late mortality; 19 patients (25%) required reintervention, including 16 (21%) LVOT-related procedures. Freedom from LVOT reintervention was 74% at 10 years and 71% at 15-20 years. Discharge LVOT velocity &amp;gt;3 metres per second (m\/s) was independently associated with LVOT reintervention (hazard ratio [HR] 11.66, 95% confidence interval [CI] 3.56-38.18; P\u2009&amp;lt;\u2009.001). Younger age was also independently associated with increased risk (HR per year 0.74, 95% CI, 0.59-0.94; P\u2009=\u2009.013) for LVOT reintervention. Coronary abnormalities were documented in 17% of patients, with one early coronary reintervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Surgical repair of supravalvar aortic stenosis is associated with excellent long-term survival. Residual discharge velocity emerged as an independent predictor of late LVOT reintervention, supporting the importance of achieving optimal haemodynamic relief at the index operation and structured lifelong surveillance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/icvts\/ivag230","type":"journal-article","created":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T12:49:06Z","timestamp":1786798146000},"source":"Crossref","is-referenced-by-count":0,"title":["Long-Term Outcomes After Supravalvar Aortic Stenosis Repair: Impact of Residual Haemodynamics on Reintervention"],"prefix":"10.1093","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6572-0090","authenticated-orcid":false,"given":"Nabil","family":"Hussein","sequence":"first","affiliation":[{"name":"Paediatric Cardiothoracic Surgery, Great Ormond Street Hospital , London, WC1N 3JH,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Branko","family":"Mimic","sequence":"additional","affiliation":[{"name":"Paediatric Cardiothoracic Surgery, Great Ormond Street Hospital , London, WC1N 3JH,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mats","family":"Synnergren","sequence":"additional","affiliation":[{"name":"Paediatric Cardiothoracic Surgery, Great Ormond Street Hospital , London, WC1N 3JH,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagarajan","family":"Muthialu","sequence":"additional","affiliation":[{"name":"Paediatric Cardiothoracic Surgery, Great Ormond Street Hospital , London, WC1N 3JH,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2023-1266","authenticated-orcid":false,"given":"Victor","family":"Tsang","sequence":"additional","affiliation":[{"name":"Paediatric Cardiothoracic Surgery, Great Ormond Street Hospital , London, WC1N 3JH,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Kostolny","sequence":"additional","affiliation":[{"name":"Paediatric Cardiothoracic Surgery, Great Ormond Street Hospital , London, WC1N 3JH,","place":["United Kingdom"]},{"name":"Institute of Cardiovascular Science, University College London (UCL) , London, WC1E 6DD,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,8,17]]},"reference":[{"key":"2026110400273052300_ivag230-B1","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1016\/j.athoracsur.2019.04.094","author":"Wu","year":"2019"},{"key":"2026110400273052300_ivag230-B2","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1093\/ejcts\/ezx245","article-title":"Early and late outcomes after surgical repair of congenital supravalvular aortic stenosis: a European Congenital Heart Surgeons Association multicentric study","volume":"52","author":"Padalino","year":"2017","journal-title":"Eur J Cardiothorac Surg"},{"key":"2026110400273052300_ivag230-B3","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezad360","article-title":"Long-term surgical outcomes of congenital supravalvular aortic stenosis: a systematic review, meta-analysis and microsimulation study","volume":"65","author":"Meccanici","year":"2024","journal-title":"Eur J Cardiothorac Surg."},{"key":"2026110400273052300_ivag230-B4","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1016\/j.athoracsur.2012.04.022","article-title":"Late outcomes for surgical repair of supravalvar aortic stenosis","volume":"94","author":"Deo","year":"2012","journal-title":"Ann Thorac Surg"},{"key":"2026110400273052300_ivag230-B5","doi-asserted-by":"publisher","DOI":"10.1093\/icvts\/ivae017","article-title":"Coronary artery lesions are associated with adverse cardiac events in children undergoing supravalvular aortic stenosis repair","volume":"38","author":"Luo","year":"2024","journal-title":"Interdiscip Cardiovasc Thorac Surg"},{"key":"2026110400273052300_ivag230-B6","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1053\/j.jvca.2020.01.022","article-title":"Anesthetic considerations for patients with Williams syndrome","volume":"35","author":"Staudt","year":"2021","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"2026110400273052300_ivag230-B7","first-page":"124","article-title":"The surgical treatment of supravalvular aortic stenosis","author":"McGoon","year":"1961","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2026110400273052300_ivag230-B8","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/S0022-5223(19)41350-0","article-title":"Supravalvular aortic stenosis. 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