{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T10:39:57Z","timestamp":1793356797329,"version":"4.5.0"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Long-term outcomes of emergent extracorporeal membrane oxygenation (ECMO) initiated outside the operating room remain poorly defined. We evaluated long-term outcomes after emergent ECMO support outside the operating room in neonates and infants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively evaluated 59 neonates and infants requiring emergent ECMO support outside the operating room at our institution (2010-2024). The primary outcome was overall survival after ECMO support. Secondary outcomes included in-hospital outcomes, mortality risk factors, and the impact of manual cardiopulmonary resuscitation (CPR) duration at ECMO cannulation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Median age and body weight at emergent ECMO were 1.6 months and 3.2 kg, respectively. Indications for ECMO were extracorporeal CPR in 40 (68%) patients, cardiogenic shock in 12 (20%), septic shock in 1 (2%), and respiratory failure in 6 (10%). The median manual CPR duration was 36 min. A CPR duration exceeding 36 min was associated with cervical ECMO cannulation (P\u2009=\u2009.001) and hypoxic encephalopathy (P\u2009=\u2009.008). The median ECMO duration was 4 days. Forty-two (71%) patients were weaned from ECMO, and 32 (54%) survived to discharge. At a median follow-up of 3.7 years, overall survival after ECMO support was 57%, 47%, and 44% at 1, 3, and 5 years, respectively. Multivariable analysis detected non-cerebral bleeding (P\u2009=\u2009.049) and lack of catheter\/surgical intervention (P\u2009=\u2009.004) as mortality risk factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Long-term survival after emergent ECMO outside the operating room was acceptable in neonates and infants. Strategies to reduce bleeding complications and minimize resuscitation time may further improve outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical trial registration number<\/jats:title>\n                    <jats:p>R19092; December 20, 2020<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/icvts\/ivag235","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T11:21:24Z","timestamp":1787570484000},"source":"Crossref","is-referenced-by-count":0,"title":["Extracorporeal Membrane Oxygenation Outside the Operating Room in Neonates and Infants"],"prefix":"10.1093","volume":"41","author":[{"given":"Keisuke","family":"Shibagaki","sequence":"first","affiliation":[{"name":"Department of Pediatric Cardiovascular Surgery, National Cerebral and Cardiovascular Center , Suita, Osaka 564-8565,","place":["Japan"]},{"name":"Department of Cardiac Surgery, Asahikawa Medical University , Asahikawa, Hokkaido 078-8510,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Tominaga","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiovascular Surgery, National Cerebral and Cardiovascular Center , Suita, Osaka 564-8565,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Takeshita","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiovascular Surgery, National Cerebral and Cardiovascular Center , Suita, Osaka 564-8565,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuji","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiovascular Surgery, National Cerebral and Cardiovascular Center , Suita, Osaka 564-8565,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaya","family":"Nakamizo","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiovascular Surgery, National Cerebral and Cardiovascular Center , Suita, Osaka 564-8565,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Kamiya","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Asahikawa Medical University , Asahikawa, Hokkaido 078-8510,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigemitsu","family":"Iwai","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiovascular Surgery, National Cerebral and Cardiovascular Center , Suita, Osaka 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