{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T11:09:48Z","timestamp":1788952188635,"version":"build-2803163510"},"reference-count":0,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"am","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Trimodality therapy, consisting of induction chemoradiotherapy followed by surgery, remains a viable treatment option for locally advanced non-small cell lung cancer (LA-NSCLC). However, because this approach constitutes highly intensive local therapy, late adverse events may contribute to long-term, non-cancer-related outcomes. This study sought to clarify the prognostic impact of these events in recurrence-free patients treated with trimodality therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective analysis of patients who underwent trimodality therapy from January 1999 to December 2021 and remained recurrence-free during the follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 199 patients who received trimodality therapy, 112 (56.3%) remained recurrence-free and were included in this analysis. Their median age at surgery was 62.5 years. The clinical stages were stage II (n\u2009=\u200927), stage III (n\u2009=\u200985). The median follow-up was 11.5 years, and the overall survival rates among patients without recurrence at 3, 5, and 10 years were 90.0%, 84.4%, and 71.5%, respectively. Multivariable analysis showed chronic lung injury extending beyond the anatomical segment (P\u2009=\u20090.04) was independent prognostic factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We observed an association between treatment-related pulmonary morbidity and long-term survival among recurrence-free patients after trimodality therapy. These findings suggest that minimizing treatment-related complications may be important for long-term outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/icvts\/ivag247","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T11:23:29Z","timestamp":1788780209000},"source":"Crossref","is-referenced-by-count":0,"title":["Impact of treatment-related complications on long-term outcomes in recurrence-free survivors with locally advanced non-small cell lung cancer after Trimodality therapy"],"prefix":"10.1093","author":[{"given":"Kazuhiro","family":"Okada","sequence":"first","affiliation":[{"name":"Okayama University Graduate School of Medicine Department of General Thoracic Surgery and Breast and Endocrinological Surgery, , Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Suzawa","sequence":"additional","affiliation":[{"name":"Okayama University Graduate School of Medicine Department of General Thoracic Surgery and Breast and Endocrinological Surgery, , Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558,","place":["Japan"]},{"name":"Okayama University Hospital Department of Thoracic Surgery, , 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Aoyama","sequence":"additional","affiliation":[{"name":"Okayama University Hospital Division of Radiological Technology, , 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Ryuko","sequence":"additional","affiliation":[{"name":"Okayama University Graduate School of Medicine Department of General Thoracic Surgery and Breast and Endocrinological Surgery, , Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558,","place":["Japan"]},{"name":"Okayama University Hospital Organ Transplant Center, , 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumi","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Okayama University Graduate School of Medicine Department of General Thoracic Surgery and Breast and Endocrinological Surgery, , Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558,","place":["Japan"]},{"name":"Okayama University Hospital Department of Thoracic Surgery, , 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruchika","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Okayama University Graduate School of Medicine Department of General Thoracic Surgery and Breast and Endocrinological Surgery, , Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558,","place":["Japan"]},{"name":"Okayama University Hospital Organ Transplant Center, , 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Okayama University Graduate School of Medicine Department of General Thoracic Surgery and Breast and Endocrinological Surgery, , Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558,","place":["Japan"]},{"name":"Okayama University Hospital Organ Transplant Center, , 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidejiro","family":"Torigoe","sequence":"additional","affiliation":[{"name":"Okayama University Graduate School of Medicine Department of General Thoracic Surgery and Breast and Endocrinological Surgery, , Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558,","place":["Japan"]},{"name":"Okayama University Hospital Department of Thoracic Surgery, , 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiko","family":"Shien","sequence":"additional","affiliation":[{"name":"Okayama University Graduate School of Medicine Department of General Thoracic Surgery and Breast and Endocrinological Surgery, , Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558,","place":["Japan"]},{"name":"Okayama University Hospital Department of Thoracic Surgery, , 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kentaroh","family":"Miyoshi","sequence":"additional","affiliation":[{"name":"Okayama University Graduate School of Medicine Department of General Thoracic Surgery and Breast and Endocrinological Surgery, , Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558,","place":["Japan"]},{"name":"Okayama University Hospital Department of Thoracic Surgery, , 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kotaro","family":"Yoshio","sequence":"additional","affiliation":[{"name":"Okayama University Department of Proton Beam Therapy, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, , 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikio","family":"Okazaki","sequence":"additional","affiliation":[{"name":"Okayama University Graduate School of Medicine Department of General Thoracic Surgery and Breast and Endocrinological Surgery, , Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558,","place":["Japan"]},{"name":"Okayama University Hospital Department of Thoracic Surgery, , 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiichiro","family":"Sugimoto","sequence":"additional","affiliation":[{"name":"Okayama University Graduate School of Medicine Department of General Thoracic Surgery and Breast and Endocrinological Surgery, , Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558,","place":["Japan"]},{"name":"Okayama University Hospital Organ Transplant Center, , 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takao","family":"Hiraki","sequence":"additional","affiliation":[{"name":"Okayama University Department of Radiology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, , 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junichi","family":"Soh","sequence":"additional","affiliation":[{"name":"Osaka Metropolitan University Graduate School of Medicine Department of Thoracic Surgery, , 1-4-3 Asahi-machi, Abeno-ku, Osaka 545-8585,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Toyooka","sequence":"additional","affiliation":[{"name":"Okayama University Graduate School of Medicine Department of General Thoracic Surgery and Breast and Endocrinological Surgery, , Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558,","place":["Japan"]},{"name":"Okayama University Hospital Department of Thoracic Surgery, , 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,9,8]]},"container-title":["Interdisciplinary CardioVascular and Thoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/icvts\/advance-article-pdf\/doi\/10.1093\/icvts\/ivag247\/71000596\/ivag247.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/icvts\/advance-article-pdf\/doi\/10.1093\/icvts\/ivag247\/71000596\/ivag247.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T10:14:34Z","timestamp":1788948874000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/icvts\/advance-article\/doi\/10.1093\/icvts\/ivag247\/8788451"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,8]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1093\/icvts\/ivag247","relation":{},"ISSN":["2753-670X"],"issn-type":[{"value":"2753-670X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,8]]},"article-number":"ivag247"}}