{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:02:02Z","timestamp":1790776922196,"version":"4.1.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the prognostic impact of preoperative self-reported global health status, assessed with the EQ-5D visual analogue scale (VAS), on recurrence-free survival (RFS) in patients undergoing resection for clinical stage I non-small cell lung cancer (NSCLC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study included 200 patients from a single-center quality-of-life assessment cohort who underwent complete resection for clinical stage I NSCLC between January 2015 and April 2018. Preoperative QOL was assessed with the EQ-5D-5L. RFS was analyzed with the Kaplan\u2013Meier method and the Cox proportional hazards model. Competing risk analysis was performed to distinguish recurrence from mortality due to other causes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The median follow-up was 6.0 years and the 5-year RFS rate was 82.2% (42 events). On univariable Cox analysis for RFS, the hazard ratio (HR) per 1-unit decrease in EQ-5D VAS scores was 1.020(95% CI 1.002\u20131.039). An EQ-5D VAS score \u226455 was also associated with worse RFS (HR 2.762, 95% CI 1.271\u20136.005; p\u2009=\u20090.010). On competing risk analysis adjusting for Performance Status, and modified Glasgow Prognostic Score, the recurrence risk of lung cancer was significantly higher in the VAS \u226455 group (adjusted HR 3.45, 95% CI 1.09\u201310.96), whereas mortality from other causes was comparable between the 2 VAS groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Lower preoperative EQ-5D VAS scores were associated with poorer recurrence-free survival in patients with clinical stage I NSCLC, driven primarily by increased recurrence rather than by other-cause mortality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/icvts\/ivag271","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:36:31Z","timestamp":1790681791000},"source":"Crossref","is-referenced-by-count":0,"title":["Association between preoperative EQ-5D visual analogue scale score and recurrence-free survival after lung cancer resection"],"prefix":"10.1093","author":[{"given":"Hideo","family":"Ichimura","sequence":"first","affiliation":[{"name":"Institute of Medicine, University of Tsukuba Department of Thoracic Surgery, , Tsukuba, Ibaraki"},{"name":"Hitachi General Hospital Department of Thoracic Surgery, , Hitachi, Ibaraki"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisuke","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Hitachi General Hospital Department of Thoracic Surgery, , Hitachi, Ibaraki"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiko","family":"Gosho","sequence":"additional","affiliation":[{"name":"Institute of Medicine, University of Tsukuba Department of Biostatistics, , Tsukuba, Ibaraki"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Minagi","sequence":"additional","affiliation":[{"name":"Hitachi General Hospital Department of Thoracic Surgery, , Hitachi, Ibaraki"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyuki","family":"Kawamura","sequence":"additional","affiliation":[{"name":"Hitachi General Hospital Department of Thoracic Surgery, , Hitachi, Ibaraki"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuntaro","family":"Kawabata","sequence":"additional","affiliation":[{"name":"Hitachi General Hospital Department of Thoracic Surgery, , Hitachi, Ibaraki"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisashi","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Hitachi General Hospital Department of Thoracic Surgery, , Hitachi, Ibaraki"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinsuke","family":"Kitazawa","sequence":"additional","affiliation":[{"name":"Institute of Medicine, University of Tsukuba Department of Thoracic Surgery, , Tsukuba, Ibaraki"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naohiro","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Institute of Medicine, University of Tsukuba Department of Thoracic Surgery, , Tsukuba, Ibaraki"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukinobu","family":"Goto","sequence":"additional","affiliation":[{"name":"Institute of Medicine, University of Tsukuba Department of Thoracic Surgery, , Tsukuba, Ibaraki"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukio","family":"Sato","sequence":"additional","affiliation":[{"name":"Institute of Medicine, University of Tsukuba Department of Thoracic Surgery, , Tsukuba, Ibaraki"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,9,30]]},"container-title":["Interdisciplinary CardioVascular and Thoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/icvts\/advance-article-pdf\/doi\/10.1093\/icvts\/ivag271\/71523072\/ivag271.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/icvts\/advance-article-pdf\/doi\/10.1093\/icvts\/ivag271\/71523072\/ivag271.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:47:00Z","timestamp":1790776020000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/icvts\/advance-article\/doi\/10.1093\/icvts\/ivag271\/8853825"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,30]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1093\/icvts\/ivag271","relation":{},"ISSN":["2753-670X"],"issn-type":[{"value":"2753-670X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,30]]},"article-number":"ivag271"}}