{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T04:07:24Z","timestamp":1790136444452,"version":"4.0.1"},"reference-count":0,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"am","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study evaluated the physiological impact of CABG for left anterior descending (LAD) artery chronic total occlusion (CTO) using postoperative coronary flow reserve (CFR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed 1,149 patients undergoing isolated CABG, comparing LAD-CTO (n\u2009=\u2009164) and non-CTO (n\u2009=\u2009985) groups. Postoperative CFR was measured in 685 patients. The CTO group was stratified by preoperative Rentrop collateral classification.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the entire cohort (n\u2009=\u20091,149), early mortality (3.7% vs. 1.7%, p\u2009=\u20090.1018) and LAD graft patency (97.8% vs. 98.6%, p\u2009=\u20090.4595) were comparable between groups. In the CFR cohort (n\u2009=\u2009685), the CTO group showed lower CFR values than the non-CTO group (2.76 \u00b1 0.90 vs. 3.04 \u00b1 0.88, p\u2009=\u20090.0012). However, mean CFR exceeded 2.0 across all CTO subgroups, regardless of collateral status (Poor: 2.66 \u00b1 0.7; Moderate: 2.76 \u00b10.94; Good: 2.78 \u00b1 1.00; p\u2009=\u20090.763).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>CABG achieves reliable physiological improvement (CFR &amp;gt; 2.0) and favorable outcomes for LAD-CTO revascularization, independent of preoperative Rentrop collateral grade.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/icvts\/ivag273","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T11:35:46Z","timestamp":1790076946000},"source":"Crossref","is-referenced-by-count":0,"title":["Physiological impact of coronary artery bypass surgery on chronic total occlusion: a functional evaluation using coronary flow reserve"],"prefix":"10.1093","author":[{"given":"Kentaro","family":"Honda","sequence":"first","affiliation":[{"name":"Wakayama Medical University Department of Thoracic and Cardiovascular Surgery, , 594-1153, 811-1, Kimiidera, Wakayama city, Wakayama,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Kunimoto","sequence":"additional","affiliation":[{"name":"Wakayama Medical University Department of Thoracic and Cardiovascular Surgery, , 594-1153, 811-1, Kimiidera, Wakayama city, Wakayama,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Wakayama Medical University Department of Thoracic and Cardiovascular Surgery, , 594-1153, 811-1, Kimiidera, Wakayama city, Wakayama,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Fujimoto","sequence":"additional","affiliation":[{"name":"Wakayama Medical University Department of Thoracic and Cardiovascular Surgery, , 594-1153, 811-1, Kimiidera, Wakayama city, Wakayama,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Kajimoto","sequence":"additional","affiliation":[{"name":"Wakayama Medical University Department of Thoracic and Cardiovascular Surgery, , 594-1153, 811-1, Kimiidera, Wakayama city, Wakayama,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mizuho","family":"Ikuchi","sequence":"additional","affiliation":[{"name":"Wakayama Medical University Department of Thoracic and Cardiovascular Surgery, , 594-1153, 811-1, Kimiidera, Wakayama city, Wakayama,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kota","family":"Agematsu","sequence":"additional","affiliation":[{"name":"Wakayama Medical University Department of Thoracic and Cardiovascular Surgery, , 594-1153, 811-1, Kimiidera, Wakayama city, Wakayama,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiharu","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Wakayama Medical University Department of Thoracic and Cardiovascular Surgery, , 594-1153, 811-1, Kimiidera, Wakayama city, Wakayama,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,9,22]]},"container-title":["Interdisciplinary CardioVascular and Thoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/icvts\/advance-article-pdf\/doi\/10.1093\/icvts\/ivag273\/71322674\/ivag273.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/icvts\/advance-article-pdf\/doi\/10.1093\/icvts\/ivag273\/71322674\/ivag273.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T03:45:15Z","timestamp":1790135115000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/icvts\/advance-article\/doi\/10.1093\/icvts\/ivag273\/8829344"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,22]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1093\/icvts\/ivag273","relation":{},"ISSN":["2753-670X"],"issn-type":[{"value":"2753-670X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,22]]},"article-number":"ivag273"}}