{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:26:14Z","timestamp":1761060374091},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,10,1]]},"DOI":"10.1093\/icvts\/ivx153","type":"journal-article","created":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T16:03:10Z","timestamp":1498233790000},"page":"571-574","source":"Crossref","is-referenced-by-count":17,"title":["Increased blood levels of transforming growth factor \u03b2 in patients with aortic dilatation"],"prefix":"10.1093","volume":"25","author":[{"given":"Carmen","family":"Rueda-Mart\u00ednez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oscar","family":"Lamas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Carrasco-Chinchilla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Robledo-Carmona","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Porras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gemma","family":"S\u00e1nchez-Esp\u00edn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel Jim\u00e9nez","family":"Navarro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Borja","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2017,6,28]]},"reference":[{"key":"key\n\t\t\t\t20171012010937_ivx153-B1","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1161\/01.CIR.0000027905.26586.E8","article-title":"Clinical and pathophysiological implications of a bicuspid aortic valve","volume":"106","year":"2002","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20171012010937_ivx153-B2","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/j.jacc.2014.04.073","article-title":"A roadmap to investigate the genetic basis of bicuspid aortic valve and its complications: insights from the International BAVCon (Bicuspid Aortic Valve Consortium)","volume":"64","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"key\n\t\t\t\t20171012010937_ivx153-B3","first-page":"145202","article-title":"Bicuspid aortic valve disease and ascending aortic aneurysms: gaps in knowledge","volume":"2012","year":"2012","journal-title":"Cardiol Res Pract"},{"key":"key\n\t\t\t\t20171012010937_ivx153-B4","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1161\/CIRCRESAHA.113.300675","article-title":"Genetics of thoracic aortic aneurysm: at the crossroad of transforming growth factor-\u03b2 signaling and vascular smooth muscle cell contractility","volume":"113","year":"2013","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20171012010937_ivx153-B5","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1056\/NEJMra1207059","article-title":"Aortic dilatation in patients with bicuspid aortic valve","volume":"370","year":"2014","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20171012010937_ivx153-B6","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1002\/clc.22320","article-title":"Total serum transforming growth factor-\u03b21 is elevated in the entire spectrum of genetic aortic syndromes","volume":"37","year":"2014","journal-title":"Clin Cardiol"},{"key":"key\n\t\t\t\t20171012010937_ivx153-B7","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.carpath.2009.09.008","article-title":"Causes and histopathology of ascending aortic disease in children and young adults","volume":"20","year":"2011","journal-title":"Cardiovasc Pathol"},{"key":"key\n\t\t\t\t20171012010937_ivx153-B8","doi-asserted-by":"crossref","first-page":"3443","DOI":"10.1016\/j.ijcard.2013.04.180","article-title":"Hereditary patterns of bicuspid aortic valve in a hundred families","volume":"168","year":"2013","journal-title":"Int J Cardiol"},{"key":"key\n\t\t\t\t20171012010937_ivx153-B9","doi-asserted-by":"crossref","first-page":"e97449","DOI":"10.1371\/journal.pone.0097449","article-title":"Selection of reference genes for quantitative real time PCR (qPCR) assays in tissue from human ascending aorta","volume":"9","year":"2014","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20171012010937_ivx153-B10","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/0002-9149(89)90430-X","article-title":"Two-dimensional echocardiographic aortic root dimensions in normal children and adults","volume":"64","year":"1989","journal-title":"Am J Cardiol"},{"key":"key\n\t\t\t\t20171012010937_ivx153-B11","first-page":"e27","article-title":"2010 ACCF\/AHA\/AATS\/ACR\/ASA\/SCA\/SCAI\/SIR\/STS\/SVM Guidelines for the diagnosis and management of patients with thoracic aortic disease. A Report of the American College of Cardiology Foundation\/American Heart Association Task Force on Practice Guidelines, American Association for Thoracic Surgery, American College of Radiology, American Stroke Association, Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, Society of Interventional Radiology, Society of Thoracic Surgeons, and Society for Vascular Medicine","volume":"55","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"key\n\t\t\t\t20171012010937_ivx153-B12","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/path.2516","article-title":"Syndromic and non-syndromic aneurysms of the human ascending aorta share activation of the Smad2 pathway","volume":"218","year":"2009","journal-title":"J Pathol"},{"key":"key\n\t\t\t\t20171012010937_ivx153-B13","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1161\/CIRCRESAHA.113.301989","article-title":"Modifications of chromatin dynamics control Smad2 pathway activation in aneurysmal smooth muscle cells","volume":"113","year":"2013","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20171012010937_ivx153-B14","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1042\/CS20120324","article-title":"Early cell changes and TGFbeta pathway alterations in the aortopathy associated with bicuspid aortic valve stenosis","volume":"124","year":"2013","journal-title":"Clin Sci"},{"key":"key\n\t\t\t\t20171012010937_ivx153-B15","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1161\/CIRCULATIONAHA.104.523357","article-title":"Overexpression of transforming growth factor-beta1 stabilizes already-formed aortic aneurysms: a first approach to induction of functional healing by endovascular gene therapy","volume":"112","year":"2005","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20171012010937_ivx153-B16","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1172\/JCI38136","article-title":"TGF-beta activity protects against inflammatory aortic aneurysm progression and complications in angiotensin II-infused mice","volume":"120","year":"2010","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20171012010937_ivx153-B17","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1159\/000151766","article-title":"Transforming growth factor-beta signaling in thoracic aortic aneurysm development: a paradox in pathogenesis","volume":"46","year":"2009","journal-title":"J Vasc Res"}],"container-title":["Interactive CardioVascular and Thoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/icvts\/article-pdf\/25\/4\/571\/20146921\/ivx153.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,10,12]],"date-time":"2017-10-12T01:09:42Z","timestamp":1507770582000},"score":1,"resource":{"primary":{"URL":"http:\/\/academic.oup.com\/icvts\/article\/25\/4\/571\/3897348\/Increased-blood-levels-of-transforming-growth"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,28]]},"references-count":17,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2017,6,28]]},"published-print":{"date-parts":[[2017,10,1]]}},"URL":"https:\/\/doi.org\/10.1093\/icvts\/ivx153","relation":{},"ISSN":["1569-9293","1569-9285"],"issn-type":[{"value":"1569-9293","type":"print"},{"value":"1569-9285","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2017,10]]},"published":{"date-parts":[[2017,6,28]]}}}