{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T15:31:51Z","timestamp":1766158311003,"version":"3.37.3"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2019,6,9]],"date-time":"2019-06-09T00:00:00Z","timestamp":1560038400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100007052","name":"University of Verona","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004770","name":"University of Parma","doi-asserted-by":"publisher","award":["FFBR-MIUR-2017"],"award-info":[{"award-number":["FFBR-MIUR-2017"]}],"id":[{"id":"10.13039\/501100004770","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p\/>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>The timing for pulmonary valve replacement (PVR) after tetralogy of Fallot repair is controversial, due to limitations in estimating right ventricular dysfunction and recovery. Intraoperative imaging could add prognostic information, but transoesophageal echocardiography is unsuitable for exploring right heart function. Right ventricular function after PVR was investigated in real time using a novel video-based contactless kinematic evaluation technology (Vi.Ki.E.), which calculates cardiac fatigue and energy consumption.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Six consecutive patients undergoing PVR at 13.8\u2009\u00b1\u20092.6\u2009years (range 6.9\u201319.8) after the repair of tetralogy of Fallot were enrolled. Mean right ventricular end-diastolic and end-systolic volume at magnetic resonance imaging were 115.6\u2009\u00b1\u200916.2\u2009ml\/m2 and 61.5\u2009\u00b1\u200914.6\u2009ml\/m2, respectively. Vi.Ki.E. uses a fast-resolution camera placed 45\u2009cm above the open chest, recording cardiac kinematics before and after PVR. An algorithm defines cardiac parameters, such as energy, fatigue, maximum contraction velocity and tissue displacement.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>There were no perioperative complications, with patients discharged in satisfactory clinical conditions after 7\u2009\u00b1\u20092\u2009days (range 5\u20139). Vi.Ki.E. parameters describing right ventricular dysfunction decreased significantly after surgery: energy consumption by 45% [271\u2009125\u2009\u00b1\u20099422 (mm\/s)2 vs 149\u2009202\u2009\u00b1\u200911\u2009980 (mm\/s)2, P\u2009=\u20090.0001], cardiac fatigue by 12% (292\u2009671\u2009\u00b1\u200929\u2009369\u2009mm\/s2 vs 258\u2009755\u2009\u00b1\u200942\u2009750\u2009mm\/s2, P\u2009=\u20090.01), contraction velocity by 54% (3412\u2009\u00b1\u2009749\u2009mm\/s vs 1579\u2009\u00b1\u2009400\u2009mm\/s, P\u2009=\u20090.0007) and displacement by 23% (27\u2009\u00b1\u20094\u2009mm vs 21\u2009\u00b1\u20094\u2009mm, P\u2009=\u20090.01). Patients undergoing PVR at lower end-diastolic volumes, had greater functional recovery of Vi.Ki.E. parameters.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Intraoperative Vi.Ki.E shows immediate recovery of right ventricular mechanics after PVR with less cardiac fatigue and energy consumption, providing novel insights that may have a prognostic relevance for functional recovery.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/icvts\/ivz120","type":"journal-article","created":{"date-parts":[[2019,4,18]],"date-time":"2019-04-18T15:13:40Z","timestamp":1555600420000},"page":"625-631","source":"Crossref","is-referenced-by-count":7,"title":["Real-time video kinematic evaluation of the in situ beating right ventricle after pulmonary valve replacement in patients with tetralogy of Fallot: a pilot study"],"prefix":"10.1093","volume":"29","author":[{"given":"Giacomo","family":"Rozzi","sequence":"first","affiliation":[{"name":"Department of Surgery, Dentistry, Pediatrics and Gynaecology, University of Verona, Verona, Italy"},{"name":"Department of Medicine and Surgery, University of Parma, Parma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4730-2458","authenticated-orcid":false,"given":"Francesco P","family":"Lo Muzio","sequence":"additional","affiliation":[{"name":"Department of Surgery, Dentistry, Pediatrics and Gynaecology, University of Verona, Verona, Italy"},{"name":"Department of Medicine and Surgery, University of Parma, Parma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7509-9362","authenticated-orcid":false,"given":"Camilla","family":"Sandrini","sequence":"additional","affiliation":[{"name":"Department of Surgery, Dentistry, Pediatrics and Gynaecology, University of Verona, Verona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Rossi","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, University of Parma, Parma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo","family":"Fassina","sequence":"additional","affiliation":[{"name":"Department of Electrical, Computer and Biomedical Engineering, University of Pavia, Pavia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Faggian","sequence":"additional","affiliation":[{"name":"Department of Surgery, Dentistry, Pediatrics and Gynaecology, University of Verona, Verona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Miragoli","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, University of Parma, Parma, Italy"},{"name":"Humanitas Clinical and Research Center, Rozzano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni Battista","family":"Luciani","sequence":"additional","affiliation":[{"name":"Department of Surgery, Dentistry, Pediatrics and Gynaecology, University of Verona, Verona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,6,9]]},"reference":[{"key":"2019112610305222100_ivz120-B1","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/S0140-6736(00)02714-8","article-title":"Risk factors for arrhythmia and sudden cardiac death late after repair of tetralogy of Fallot: a multicentre study","volume":"356","author":"Gatzoulis","year":"2000","journal-title":"Lancet"},{"key":"2019112610305222100_ivz120-B2","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.1016\/j.jacc.2013.04.107","article-title":"Pulmonary valve replacement after operative repair of tetralogy of Fallot: meta-analysis and meta-regression of 3,118 patients from 48 studies","volume":"62","author":"Ferraz Cavalcanti","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"2019112610305222100_ivz120-B3","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1161\/CIRCULATIONAHA.108.775221","article-title":"Pulmonary valve replacement in tetralogy of Fallot: impact on survival and ventricular tachycardia","volume":"119","author":"Harrild","year":"2009","journal-title":"Circulation"},{"key":"2019112610305222100_ivz120-B4","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1161\/CIRCULATIONAHA.117.027402","article-title":"Immediate and midterm cardiac remodeling after surgical pulmonary valve replacement in adults with repaired tetralogy of Fallot: a prospective cardiovascular magnetic resonance and clinical study","volume":"136","author":"Heng","year":"2017","journal-title":"Circulation"},{"key":"2019112610305222100_ivz120-B5","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1093\/eurheartj\/ehv550","article-title":"A propensity score-adjusted analysis of clinical outcomes after pulmonary valve replacement in tetralogy of Fallot","volume":"37","author":"Bokma","year":"2016","journal-title":"Eur Heart J"},{"key":"2019112610305222100_ivz120-B6","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1161\/CIRCULATIONAHA.108.190811","article-title":"ACC\/AHA 2008 Guidelines for the Management of Adults with Congenital Heart Disease: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines (writing committee to develop guidelines on the management of adults with congenital heart disease)","volume":"118","author":"Warnes","year":"2008","journal-title":"Circulation"},{"key":"2019112610305222100_ivz120-B7","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1093\/eurheartj\/ehv550","article-title":"Preoperative thresholds for mid-to-late haemodynamic and clinical outcomes after pulmonary valve replacement in tetralogy of Fallot","volume":"37","author":"Bokma","year":"2016","journal-title":"Eur Heart J"},{"key":"2019112610305222100_ivz120-B8","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.1161\/CIRCULATIONAHA.118.034740","article-title":"Preoperative predictors of death and sustained ventricular tachycardia after pulmonary valve replacement in patients with repaired tetralogy of Fallot enrolled in the INDICATOR cohort","volume":"138","author":"Geva","year":"2018","journal-title":"Circulation"},{"key":"2019112610305222100_ivz120-B9","doi-asserted-by":"crossref","first-page":"e0162986.","DOI":"10.1371\/journal.pone.0162986","article-title":"Patient-specific MRI-based right ventricle models using different zero-load diastole and systole geometries for better cardiac stress and strain calculations and pulmonary valve replacement surgical outcome predictions","volume":"11","author":"Tang","year":"2016","journal-title":"PLoS One"},{"key":"2019112610305222100_ivz120-B10","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1007\/s00246-018-1813-z","article-title":"Flow energy loss as a predictive parameter for right ventricular deterioration caused by pulmonary regurgitation after tetralogy of Fallot repair","volume":"39","author":"Shibata","year":"2018","journal-title":"Pediatr Cardiol"},{"key":"2019112610305222100_ivz120-B11","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/apha.12904","article-title":"Isolated pulmonary regurgitation causes decreased right ventricular longitudinal function and compensatory increased septal pumping in a porcine model","volume":"221","author":"Kopic","year":"2017","journal-title":"Acta Physiol"},{"key":"2019112610305222100_ivz120-B12","doi-asserted-by":"crossref","first-page":"46143.","DOI":"10.1038\/srep46143","article-title":"Cardiac kinematic parameters computed from video of in situ beating heart","volume":"7","author":"Fassina","year":"2017","journal-title":"Sci Rep"},{"key":"2019112610305222100_ivz120-B13","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1161\/CIRCIMAGING.108.783795","article-title":"Functional analysis of the components of the right ventricle in the setting of tetralogy of Fallot","volume":"1","author":"Bodhey","year":"2008","journal-title":"Circ Cardiovasc Imaging"},{"key":"2019112610305222100_ivz120-B14","doi-asserted-by":"crossref","first-page":"546","DOI":"10.5301\/IJAO.2011.8510","article-title":"Video evaluation of the kinematics and dynamics of the beating cardiac syncytium: an alternative to the Langendorff method","volume":"34","author":"Fassina","year":"2011","journal-title":"Int J Artif Organs"},{"key":"2019112610305222100_ivz120-B15","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.yjmcc.2015.11.007","article-title":"The cross-bridge dynamics is determined by two length-independent kinetics: implications on muscle economy and Frank-Starling Law","volume":"90","author":"Amiad Pavlov","year":"2016","journal-title":"J Mol Cell Cardiol"},{"key":"2019112610305222100_ivz120-B16","doi-asserted-by":"crossref","first-page":"S182","DOI":"10.1161\/CIRCULATIONAHA.107.756825","article-title":"Biventricular response after pulmonary valve replacement for right ventricular outflow tract dysfunction: is age a predictor of outcome?","volume":"118","author":"Frigiola","year":"2008","journal-title":"Circulation"},{"key":"2019112610305222100_ivz120-B17","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/j.ijcard.2016.07.120","article-title":"Defining and refining indications for transcatheter pulmonary valve replacement in patients with repaired tetralogy of Fallot: contributions from anatomical and functional imaging","volume":"221","author":"Tretter","year":"2016","journal-title":"Int J Cardiol"},{"key":"2019112610305222100_ivz120-B18","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1016\/j.jtcvs.2011.10.066","article-title":"Power loss and right ventricular efficiency in patients after tetralogy of Fallot repair with pulmonary insufficiency: clinical implications","volume":"143","author":"Fogel","year":"2012","journal-title":"J Thorac Cardiovasc Surg"}],"container-title":["Interactive CardioVascular and Thoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/icvts\/article-pdf\/29\/4\/625\/30053366\/ivz120.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/icvts\/article-pdf\/29\/4\/625\/30053366\/ivz120.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,11,26]],"date-time":"2019-11-26T11:23:04Z","timestamp":1574767384000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/icvts\/article\/29\/4\/625\/5513097"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,9]]},"references-count":18,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2019,6,9]]},"published-print":{"date-parts":[[2019,10,1]]}},"URL":"https:\/\/doi.org\/10.1093\/icvts\/ivz120","relation":{},"ISSN":["1569-9285"],"issn-type":[{"type":"electronic","value":"1569-9285"}],"subject":[],"published-other":{"date-parts":[[2019,10]]},"published":{"date-parts":[[2019,6,9]]}}}