{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T18:08:43Z","timestamp":1767895723076,"version":"3.49.0"},"reference-count":5,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2019,6,9]],"date-time":"2019-06-09T00:00:00Z","timestamp":1560038400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Autoimmune diseases associated with thymoma are well known, with myasthenia gravis being the most common, while autoimmune hepatitis (AIH) is extremely rare. The case of a 63-year-old woman with AIH that developed during preoperative chemotherapy for invasive type B2 thymoma is presented. Liver dysfunction was improved by steroid treatment using oral prednisolone, 30\u2009mg daily, followed by tapering. The patient underwent a macroscopic complete resection including dissemination, and no evidence of recurrence has been seen for 13\u2009months. Although the serum levels of anti-acetylcholine receptor antibody were elevated, no symptoms of myasthenia gravis appeared during the clinical course. This is a rare case of non-myasthenic thymoma complicated with AIH. AIH should be carefully considered in thymoma patients with liver dysfunction, since multidisciplinary treatment is required for invasive thymoma.<\/jats:p>","DOI":"10.1093\/icvts\/ivz138","type":"journal-article","created":{"date-parts":[[2019,5,10]],"date-time":"2019-05-10T07:21:01Z","timestamp":1557472861000},"page":"635-637","source":"Crossref","is-referenced-by-count":4,"title":["Autoimmune hepatitis during preoperative chemotherapy in a patient with thymoma"],"prefix":"10.1093","volume":"29","author":[{"given":"Tomoki","family":"Nishimura","sequence":"first","affiliation":[{"name":"Division of Thoracic Surgery, Department of Surgery, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Tsunezuka","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery, Department of Surgery, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7238-3352","authenticated-orcid":false,"given":"Naoko","family":"Miyata","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery, Department of Surgery, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayoshi","family":"Inoue","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery, Department of Surgery, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,6,9]]},"reference":[{"key":"2019092508414655800_ivz138-B1","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/cmi.2010.74","article-title":"Thymoma and autoimmunity","volume":"8","author":"Shelly","year":"2011","journal-title":"Cell Mol Immunol"},{"key":"2019092508414655800_ivz138-B2","doi-asserted-by":"crossref","first-page":"e87","DOI":"10.1097\/JTO.0b013e318298832b","article-title":"Acute autoimmune hepatitis, myositis, and myasthenic crisis in a patient with thymoma","volume":"8","author":"Rajan","year":"2013","journal-title":"J Thorac Oncol"},{"key":"2019092508414655800_ivz138-B3","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1002\/hep.23588","article-title":"Drug-induced autoimmune hepatitis: clinical characteristics and prognosis","volume":"51","author":"Bj\u00f6rnsson","year":"2010","journal-title":"Hepatology"},{"key":"2019092508414655800_ivz138-B4","doi-asserted-by":"crossref","first-page":"1.","DOI":"10.1155\/2014\/470425","article-title":"Prophylactic efficacy of melatonin on cyclophosphamide-induced liver toxicity in mice","volume":"2014","author":"Shokrzadeh","year":"2014","journal-title":"Biomed Res Int"},{"key":"2019092508414655800_ivz138-B5","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1016\/j.jtcvs.2008.04.012","article-title":"Spontaneous regression of a mediastinal thymoma","volume":"137","author":"Huang","year":"2009","journal-title":"J Thorac Cardiovasc Surg"}],"container-title":["Interactive CardioVascular and Thoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/icvts\/advance-article-pdf\/doi\/10.1093\/icvts\/ivz138\/28788097\/ivz138.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/icvts\/article-pdf\/29\/4\/635\/30053362\/ivz138.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,25]],"date-time":"2019-09-25T08:43:30Z","timestamp":1569401010000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/icvts\/article\/29\/4\/635\/5513098"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,9]]},"references-count":5,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2019,6,9]]},"published-print":{"date-parts":[[2019,10,1]]}},"URL":"https:\/\/doi.org\/10.1093\/icvts\/ivz138","relation":{},"ISSN":["1569-9285"],"issn-type":[{"value":"1569-9285","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,10]]},"published":{"date-parts":[[2019,6,9]]}}}