{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T13:14:52Z","timestamp":1769346892328,"version":"3.49.0"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2019,8,13]],"date-time":"2019-08-13T00:00:00Z","timestamp":1565654400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>There is evidence that, in adult cardiac surgical patients undergoing on-pump procedures, tranexamic acid (TXA) dose-dependently increases the risk of convulsive seizure (CS). We aimed to investigate whether a single TXA bolus of 1\u2009g influences the risk of CS in patients who were operated on without the use of cardiopulmonary bypass. In 2249 propensity-score-matched pairs who underwent off-pump coronary artery bypass grafting with or without TXA administration, the risk of CS was 0.5% and 0.3% in the TXA and non-TXA groups, respectively (P\u2009=\u20090.36). In the subgroups of patients with estimated glomerular filtration rates &lt;30, 30\u201360 and &gt;60\u2009ml\/min\/1.73 m2, the risk of CS in the TXA group was 2.8%, 1.2% and 0.4%, respectively (P\u2009=\u20090.002), and in the non-TXA group 0.0%, 0.0% and 0.3%, respectively (P\u2009=\u20090.36). The risk of stroke, in-hospital mortality and 30-day mortality did not differ significantly between study groups (P-value &gt;0.05). Our data indicate that in patients undergoing off-pump coronary artery bypass grafting, a single TXA bolus of 1\u2009g generally does not increase the risk of CS. However, the presence and extent of renal insufficiency have a very significant impact on the incidence of CS even after single-dose TXA.<\/jats:p>","DOI":"10.1093\/icvts\/ivz188","type":"journal-article","created":{"date-parts":[[2019,8,6]],"date-time":"2019-08-06T15:13:48Z","timestamp":1565104428000},"page":"852-854","source":"Crossref","is-referenced-by-count":8,"title":["Tranexamic acid and convulsive seizures after off-pump coronary artery bypass surgery: the role of renal insufficiency"],"prefix":"10.1093","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5070-0249","authenticated-orcid":false,"given":"Nikolai","family":"Hulde","sequence":"first","affiliation":[{"name":"Institute of Anesthesiology and Pain Therapy, Heart and Diabetes Center NRW, Ruhr-University Bochum, Bochum, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armin","family":"Zittermann","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Heart and Diabetes Center NRW, Ruhr-University Bochum, Bochum, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus-Andre","family":"Deutsch","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Heart and Diabetes Center NRW, Ruhr-University Bochum, Bochum, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vera","family":"von Dossow","sequence":"additional","affiliation":[{"name":"Institute of Anesthesiology and Pain Therapy, Heart and Diabetes Center NRW, Ruhr-University Bochum, Bochum, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan F","family":"Gummert","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Heart and Diabetes Center NRW, Ruhr-University Bochum, Bochum, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Koster","sequence":"additional","affiliation":[{"name":"Institute of Anesthesiology and Pain Therapy, Heart and Diabetes Center NRW, Ruhr-University Bochum, Bochum, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,8,13]]},"reference":[{"key":"2019112510403703200_ivz188-B1","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.seizure.2016.02.011","article-title":"Tranexamic acid-associated seizures: a meta-analysis","volume":"36","author":"Lin","year":"2016","journal-title":"Seizure"},{"key":"2019112510403703200_ivz188-B2","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1002\/ana.24558","article-title":"Tranexamic acid-associated seizures: causes and treatment","volume":"79","author":"Lecker","year":"2016","journal-title":"Ann 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mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage (WOMAN): an international, randomised, double-blind, placebo-controlled trial","volume":"389","year":"2017","journal-title":"Lancet"},{"key":"2019112510403703200_ivz188-B6","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1056\/NEJMoa1800942","article-title":"Tranexamic acid for the prevention of blood loss after vaginal delivery","volume":"379","author":"Sentilhes","year":"2018","journal-title":"N Engl J Med"},{"key":"2019112510403703200_ivz188-B7","doi-asserted-by":"crossref","first-page":"977","DOI":"10.5811\/westjem.2018.8.39336","article-title":"Tranexamic acid in civilian trauma care in the California prehospital antifibrinolytic therapy study","volume":"19","author":"Neeki","year":"2018","journal-title":"West J Emerg Med"},{"key":"2019112510403703200_ivz188-B8","doi-asserted-by":"crossref","first-page":"e637","DOI":"10.1097\/PCC.0000000000001724","article-title":"Safety of tranexamic acid during pediatric trauma: a nationwide database study","volume":"19","author":"Maeda","year":"2018","journal-title":"Pediatr Crit Care Med"},{"key":"2019112510403703200_ivz188-B9","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1053\/j.jvca.2010.08.012","article-title":"Tranexamic acid is associated with less blood transfusion in off-pump coronary artery bypass graft surgery: a systematic review and meta-analysis","volume":"25","author":"Adler Ma","year":"2011","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"2019112510403703200_ivz188-B10"}],"container-title":["Interactive CardioVascular and Thoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/icvts\/article-pdf\/29\/6\/852\/31117742\/ivz188.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/icvts\/article-pdf\/29\/6\/852\/31117742\/ivz188.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,11,25]],"date-time":"2019-11-25T10:42:23Z","timestamp":1574678543000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/icvts\/article\/29\/6\/852\/5549459"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,13]]},"references-count":10,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2019,8,13]]},"published-print":{"date-parts":[[2019,12,1]]}},"URL":"https:\/\/doi.org\/10.1093\/icvts\/ivz188","relation":{},"ISSN":["1569-9285"],"issn-type":[{"value":"1569-9285","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,12]]},"published":{"date-parts":[[2019,8,13]]}}}