{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T01:21:43Z","timestamp":1784856103021,"version":"3.55.0"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2019,9,20]],"date-time":"2019-09-20T00:00:00Z","timestamp":1568937600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Garfield Weston Trust","award":["PMS\/MMS\u201407\/08\u20133001"],"award-info":[{"award-number":["PMS\/MMS\u201407\/08\u20133001"]}]},{"name":"NIHR Bristol Cardiovascular Biomedical Research Centre"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p\/>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>To investigate the effect of preoperative volume replacement therapy (VRT) on renal function, health outcome and time to fitness for discharge in diabetic patients undergoing coronary artery bypass grafting (CABG).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>In 2 parallel randomized controlled trials, diabetic patients were allocated to preoperative VRT (1\u2009ml\/kg\/h of Hartmann\u2019s solution for 12\u2009h) or usual care. Primary outcome was time to fitness for discharge. Secondary outcomes included acute kidney injury, postoperative complications, patient-reported quality of life (QoL), hospital resource use and markers of renal, cardiac and inflammatory injury.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>In total, 169 patients were randomized (84 VRT, 85 usual care; mean age 64\u2009years; 88% male). Time to fitness for discharge was similar between groups [median 6\u2009days; interquartile range 5.0\u20139.0 in both groups; hazard ratio 0.95, 95% confidence interval (CI) 0.65\u20131.38; P\u2009=\u20090.78]. Postoperative acute kidney injury was not statistically different (VRT: 27.7% vs usual care: 18.8%, odds ratio 1.72, 95% CI 0.82\u20133.59; P\u2009=\u20090.15). Estimated glomerular filtration rate (mean difference \u22120.92, 95% CI \u22124.18 to 2.25; P\u2009=\u20090.56), microalbumin\/creatinine ratio [geometric mean ratio (GMR) 1.16, 95% CI 0.94\u20131.42; P\u2009=\u20090.16], N-acetyl-beta-d-glucosaminidase (GMR 1.08, 95% CI 0.83\u20131.40; P\u2009=\u20090.57), C-reactive protein (GMR 1.00, 95% CI 0.88\u20131.13; P\u2009=\u20090.94), troponin T (Trop-T; GMR 1.18, 95% CI 0.78\u20131.79; P\u2009=\u20090.39) and other secondary health outcomes were similar between groups. QoL improved in both groups at 3 months with no difference observed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>The use of preoperative VRT is not superior to usual care in diabetic patients undergoing CABG.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Clinical trial registration number<\/jats:title>\n                  <jats:p>ISRCTN02159606.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/icvts\/ivz226","type":"journal-article","created":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T07:45:38Z","timestamp":1568015138000},"page":"54-63","source":"Crossref","is-referenced-by-count":7,"title":["Preoperative VolumE Replacement therapy in DIabetic patients undergoing coronary artery bypass grafting surgery: results from an open parallel group randomized Controlled Trial (VeRDiCT)"],"prefix":"10.1093","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9148-1249","authenticated-orcid":false,"given":"Kunal","family":"Sarkar","sequence":"first","affiliation":[{"name":"Rabindranath Tagore International Institute of Cardiac Sciences (RTIICS), Kolkata, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2405-667X","authenticated-orcid":false,"given":"Rosie A","family":"Harris","sequence":"additional","affiliation":[{"name":"Clinical Trials and Evaluation Unit, Bristol Trials Centre, University of Bristol, Bristol, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sian","family":"Wells","sequence":"additional","affiliation":[{"name":"Clinical Trials and Evaluation Unit, Bristol Trials Centre, University of Bristol, Bristol, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy","family":"Harris","sequence":"additional","affiliation":[{"name":"Clinical Trials 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Bristol, Bristol, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianni D","family":"Angelini","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, Bristol Heart Institute, University of Bristol, Bristol, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie","family":"Pike","sequence":"additional","affiliation":[{"name":"Clinical Trials and Evaluation Unit, Bristol Trials Centre, University of Bristol, Bristol, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9163-0512","authenticated-orcid":false,"given":"Kate","family":"Ashton","sequence":"additional","affiliation":[{"name":"Clinical Trials and Evaluation Unit, Bristol Trials Centre, University of Bristol, Bristol, 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