{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T11:38:13Z","timestamp":1768822693894,"version":"3.49.0"},"reference-count":10,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2019,10,20]],"date-time":"2019-10-20T00:00:00Z","timestamp":1571529600000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Czech Republic Ministry of Health","award":["NV18-06-00216"],"award-info":[{"award-number":["NV18-06-00216"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Poor ventilatory efficiency, defined as the increase in minute ventilation relative to carbon dioxide production during exercise (VE\/VCO2 slope), may be associated with dynamic hyperinflation and thereby promote the development of prolonged air leak (PAL) after lung resection. Consecutive lung lobectomy candidates (n\u2009=\u200996) were recruited for this prospective two-centre study. All subjects underwent pulmonary function tests and cardiopulmonary exercise testing prior to surgery. PAL was defined as the presence of air leaks from the chest tube on the 5th postoperative day and developed in 28 (29%) subjects. Subjects with PAL were not different in terms of age, sex, American Society of Anesthesiologists class, type of surgery (thoracotomy\/video-assisted thoracoscopic surgery) and site of surgery (right\/left lung; upper\/lower lobes). Subjects with PAL had more frequent pleural adhesions (50% vs 21%; P\u2009=\u20090.006) and steeper VE\/VCO2 slope (35\u2009\u00b1\u20097 vs 30\u2009\u00b1\u20095; P\u2009=\u20090.001). Stepwise logistic regression showed that only the presence of pleural adhesions [odds ratio (OR) 3.9, 95% confidence interval (CI) 1.4\u201310.9; P\u2009=\u20090.008] and VE\/VCO2 slope (OR 1.1, 95% CI 1.0\u20131.2; P\u2009=\u20090.003) were independently associated with PAL (AUC 0.74, 95% CI 0.62\u20130.86). We conclude that a high VE\/VCO2 slope during exercise may be helpful in identifying patients at greater risk for the development of PAL after lung lobectomy.<\/jats:p>\n               <jats:p>Clinical trial registration number: ClinicalTrials.gov identifier: NCT03498352.<\/jats:p>","DOI":"10.1093\/icvts\/ivz255","type":"journal-article","created":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T19:24:53Z","timestamp":1569957893000},"source":"Crossref","is-referenced-by-count":2,"title":["Poor ventilatory efficiency during exercise may predict prolonged air leak after pulmonary lobectomy"],"prefix":"10.1093","author":[{"given":"Kristian","family":"Brat","sequence":"first","affiliation":[{"name":"Department of Respiratory Diseases, University Hospital Brno, Brno, Czech Republic"},{"name":"Faculty of Medicine, Masaryk University, Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milos","family":"Chobola","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Masaryk University, Brno, Czech Republic"},{"name":"Department of Anesthesiology and Intensive Care, St. Anne\u2019s University Hospital, Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavel","family":"Homolka","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Masaryk University, Brno, Czech Republic"},{"name":"Department of Sports Medicine and Rehabilitation, St. Anne\u2019s University Hospital, Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michaela","family":"Heroutova","sequence":"additional","affiliation":[{"name":"Department of Respiratory Diseases, University Hospital Brno, Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michal","family":"Benej","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Masaryk University, Brno, Czech Republic"},{"name":"First Department of Surgery, St. Anne\u2019s University Hospital, Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6690-1181","authenticated-orcid":false,"given":"Ladislav","family":"Mitas","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Masaryk University, Brno, Czech Republic"},{"name":"Department of Surgery, University Hospital Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lyle J","family":"Olson","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, 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