{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:14:32Z","timestamp":1740136472045,"version":"3.37.3"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2019,11,22]],"date-time":"2019-11-22T00:00:00Z","timestamp":1574380800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title\/>\n                  <jats:p>Figure 4:<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>We investigated the clinical and haemodynamic outcomes in elderly patients undergoing composite aortic root replacement.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Between 2005 and 2017, 135 patients underwent aortic root surgery at our hospital. Of these 135 patients, 47 patients aged \u226565\u2009years were included in this study. Pathologies included aneurysms in 31, chronic aortic dissection in 6, acute aortic dissection in 4 and other causes in 6 patients. A bioprosthesis was used in 27 and a mechanical valve in 20 patients. The mean age was 71.0\u2009\u00b1\u20094.3\u2009years. The mean follow-up period was 61\u2009\u00b1\u200935\u2009months. Follow-up echocardiographic data (average 48\u2009months after surgery) were collected in 35 patients (74%).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>The in-hospital mortality rate was 2.1% (1 patient). Seven late deaths occurred during follow-up. The 1-, 5- and 8-year overall survival was 93.6%, 82.9% and 82.9%, respectively. Infective endocarditis, Marfan syndrome and diabetes were independent predictors of poorer survival. During the follow-up, thromboembolism occurred in 1 patient, major bleeding events in 5 patients, or proximal reoperation for prosthetic valve endocarditis in 1 patient. The type of valve, mechanical or biological valve, did not affect late mortality and morbidity. Follow-up echocardiography revealed significantly improved left ventricular ejection fraction compared with that at discharge.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Composite aortic root replacement provided satisfactory midterm outcomes in patients aged \u226565\u2009years. Further studies with a longer follow-up are warranted to evaluate late valve-related events.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/icvts\/ivz267","type":"journal-article","created":{"date-parts":[[2019,10,18]],"date-time":"2019-10-18T15:09:54Z","timestamp":1571411394000},"page":"443-450","source":"Crossref","is-referenced-by-count":0,"title":["Contemporary outcomes of composite aortic root replacement in elderly patients"],"prefix":"10.1093","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8806-5110","authenticated-orcid":false,"given":"Homare","family":"Okamura","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery, Saitama Medical Center, Jichi Medical University, Saitama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mamoru","family":"Arakawa","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery, Saitama Medical Center, Jichi Medical University, Saitama, 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