{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T23:41:21Z","timestamp":1781134881767,"version":"3.54.1"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2020,1,31]],"date-time":"2020-01-31T00:00:00Z","timestamp":1580428800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Daniela Masi"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Although 18F-fluorodeoxyglucose positron emission tomography\/computed tomography (PET\/CT) scan has been generally validated in the staging of malignant pleural mesothelioma (MPM), its diagnostic and prognostic performances are not clearly established. Aiming to identify possible factors causing 18F-fluorodeoxyglucose PET\/CT false-negative results and influencing prognosis in MPM patients, we analysed clinical, radiometabolic and pathological features in 141 MPM patients who underwent diagnostic 18F-fluorodeoxyglucose PET\/CT scan (January 2009\u2013July 2018) at 2 high-volume institutions. The Fisher\u2019s exact test and the Cox model were used in statistical analysis. Overall detection rate was 88.3% with 16 patients (11.6%) presenting with a standardized uptake value (SUV) max &amp;lt;2.5 (PET-negative). PET-negative cases were more frequently detected in older patients (P\u2009=\u20090.027) and early-stage tumours (33.3% false-negative in stage I and 40.0% false-negative in T1-tumours, with P\u2009=\u20090.014 both). Mean SUVmax value was higher in sarcomatoid (11.8\u2009\u00b1\u20094.6) and biphasic MPM (9.3\u2009\u00b1\u20097.0), rather than in epithelioid MPM (6.9\u2009\u00b1\u20093.8, P\u2009&amp;lt;\u20090.001). Concerning overall survival, SUVmax (both as continuous and as categorical variable) was found to be a prognostic factor, in addition to stage (P\u2009=\u20090.032) and histology (P\u2009=\u20090.014) as confirmed by multivariable analysis (hazard ratio 2.65, confidence interval 1.23\u20135.70; P\u2009&amp;lt;\u20090.001). In the light of such results, we highlight that a low fluorodeoxyglucose uptake might be observed in more than 10% MPMs, especially in early-stage tumours affecting elderly patients. Furthermore, high SUVmax values significantly correlated with a worse prognosis.<\/jats:p>","DOI":"10.1093\/icvts\/ivz303","type":"journal-article","created":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T12:09:18Z","timestamp":1575374958000},"page":"593-596","source":"Crossref","is-referenced-by-count":15,"title":["18F-fluorodeoxyglucose positron emission tomography in malignant pleural mesothelioma: diagnostic and prognostic performance and its correlation to pathological results"],"prefix":"10.1093","volume":"30","author":[{"given":"Filippo","family":"Lococo","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery, Fondazione Policlinico Universitario \u201cA. Gemelli\u201d, IRCCS, Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ottavio","family":"Rena","sequence":"first","affiliation":[{"name":"Unit of Thoracic Surgery, University of Eastern Piedmont, Novara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Torricelli","sequence":"first","affiliation":[{"name":"Laboratory of Translational Research, Azienda USL di Reggio Emilia-IRCCS, Reggio Emilia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelina","family":"Filice","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, Azienda USL di Reggio Emilia-IRCCS, Reggio Emilia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian","family":"Rapicetta","sequence":"first","affiliation":[{"name":"Unit of Thoracic Surgery, Azienda USL di Reggio Emilia-IRCCS, Reggio Emilia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renzo","family":"Boldorini","sequence":"first","affiliation":[{"name":"Pathology Department, University of Eastern Piedmont, Novara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimiliano","family":"Paci","sequence":"first","affiliation":[{"name":"Unit of Thoracic Surgery, Azienda USL di Reggio Emilia-IRCCS, Reggio Emilia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8675-2435","authenticated-orcid":false,"given":"Annibale","family":"Versari","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, Azienda USL di Reggio Emilia-IRCCS, Reggio Emilia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,1,31]]},"reference":[{"key":"2020032715451889500_ivz303-B1","doi-asserted-by":"crossref","first-page":"290","DOI":"10.3816\/CLC.2004.n.008","article-title":"Integration of multimodality approaches in the management of malignant pleural mesothelioma","volume":"5","author":"Martino","year":"2004","journal-title":"Clin Lung Cancer"},{"key":"2020032715451889500_ivz303-B2","article-title":"Survival results in biphasic malignant pleural mesothelioma patients: a multicentric analysis","author":"Lococo","year":"2019","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2020032715451889500_ivz303-B3","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/s11604-016-0555-1","article-title":"Present and future roles of FDG-PET\/CT imaging in the management of malignant pleural mesothelioma","volume":"34","author":"Kitajima","year":"2016","journal-title":"Jpn J 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mesothelioma?","volume":"12","author":"Sharif","year":"2011","journal-title":"Interact CardioVasc Thorac Surg"},{"key":"2020032715451889500_ivz303-B10","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1007\/s00259-018-4056-6","article-title":"FDG PET-derived parameters as prognostic tool in progressive malignant pleural mesothelioma treated patients","volume":"45","author":"Incerti","year":"2018","journal-title":"Eur J Nucl Med Mol Imaging"}],"container-title":["Interactive CardioVascular and Thoracic 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