{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T10:34:46Z","timestamp":1777631686285,"version":"3.51.4"},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2020,1,21]],"date-time":"2020-01-21T00:00:00Z","timestamp":1579564800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>In cardiac surgical patients, tranexamic acid (TXA) has been associated with an increased risk of convulsive seizure (CS). We aimed to investigate whether in patients undergoing isolated coronary artery bypass grafting (CABG) surgery the use of cardiopulmonary bypass (CPB) impacts the risk of CS. We studied 4198 propensity score matched patients. Patients who underwent CABG surgery without CPB, received a single bolus of 1\u2009g TXA. Patients who underwent CABG with CPB, additionally received a TXA dose of 0.5\u2009g in the CPB prime and an infusion of 0.2\u2009g\/h until the end of CPB. The risk of CS in the CPB group and the group without CPB was 0.7% and 0.6%, respectively (risk ratio 1.08, 95% confidence interval 0.51\u20132.30; P\u2009&amp;gt;\u20090.99). Kidney function was significantly associated with the risk of CS (P\u2009=\u20090.005), the latter being highest in patients with glomerular filtration rates &amp;lt;30\u2009ml\/min\/1.73 m2 (2.2%) and lowest in those patients with values &amp;gt;60\u2009ml\/min\/1.73 m2 (0.4%). Our data in patients undergoing isolated CABG indicate no significant effect on CS risk by use of CPB when TXA doses of up to \u223c2\u2009g are given. However, caution regarding TXA administration is necessary in patients with renal impairment.<\/jats:p>","DOI":"10.1093\/icvts\/ivz316","type":"journal-article","created":{"date-parts":[[2019,12,30]],"date-time":"2019-12-30T20:10:23Z","timestamp":1577736623000},"page":"538-540","source":"Crossref","is-referenced-by-count":7,"title":["Tranexamic acid and convulsive seizures after isolated coronary artery bypass surgery: the role of cardiopulmonary bypass and renal function"],"prefix":"10.1093","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5070-0249","authenticated-orcid":false,"given":"Nikolai","family":"Hulde","sequence":"first","affiliation":[{"name":"Institute of Anesthesiology and Pain Therapy, Heart and Diabetes Center NRW, Ruhr-University Bochum, Bad Oeynhausen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6085-6554","authenticated-orcid":false,"given":"Armin","family":"Zittermann","sequence":"first","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Heart and Diabetes Center NRW, Ruhr-University Bochum, Bad Oeynhausen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus-Andre","family":"Deutsch","sequence":"first","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Heart and Diabetes Center NRW, Ruhr-University Bochum, Bad Oeynhausen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vera","family":"von Dossow","sequence":"first","affiliation":[{"name":"Institute of Anesthesiology and Pain Therapy, Heart and Diabetes Center NRW, Ruhr-University Bochum, Bad Oeynhausen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan F","family":"Gummert","sequence":"first","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Heart and Diabetes Center NRW, Ruhr-University Bochum, Bad Oeynhausen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Koster","sequence":"first","affiliation":[{"name":"Institute of Anesthesiology and Pain Therapy, Heart and Diabetes Center NRW, Ruhr-University Bochum, Bad Oeynhausen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,1,21]]},"reference":[{"key":"2020032715450479800_ivz316-B1","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1002\/ana.24558","article-title":"Tranexamic acid-associated seizures: causes and treatment","volume":"79","author":"Lecker","year":"2016","journal-title":"Ann Neurol"},{"key":"2020032715450479800_ivz316-B2","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.seizure.2016.02.011","article-title":"Tranexamic acid-associated seizures: a meta-analysis","volume":"36","author":"Lin","year":"2016","journal-title":"Seizure"},{"key":"2020032715450479800_ivz316-B3","doi-asserted-by":"crossref","first-page":"S176","DOI":"10.1161\/CIRCULATIONAHA.111.084285","article-title":"Clampless off-pump versus conventional coronary artery revascularization: a propensity score analysis of 788 patients","volume":"126","author":"B\u00f6rgermann","year":"2012","journal-title":"Circulation"},{"key":"2020032715450479800_ivz316-B4","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1093\/bja\/aes310","article-title":"Moderate dosage of tranexamic acid during cardiac surgery with cardiopulmonary bypass and convulsive seizures: incidence and clinical outcome","volume":"110","author":"Koster","year":"2013","journal-title":"Br J Anaesth"},{"key":"2020032715450479800_ivz316-B5","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1056\/NEJMoa1606424","article-title":"Tranexamic acid in patients undergoing coronary-artery surgery","volume":"376","author":"Myles","year":"2017","journal-title":"N Engl J Med"},{"key":"2020032715450479800_ivz316-B6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/MBC.0000000000000789","article-title":"What concentration of tranexamic acid is needed to inhibit fibrinolysis? A systematic review of pharmacodynamics studies","volume":"30","author":"Picetti","year":"2019","journal-title":"Blood Coagul Fibrinolysis"},{"key":"2020032715450479800_ivz316-B7","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1093\/bja\/aet255","article-title":"Population pharmacokinetics of tranexamic acid in adults undergoing cardiac surgery with cardiopulmonary bypass","volume":"111","author":"Grassin-Delyle","year":"2013","journal-title":"Br J Anaesth"},{"key":"2020032715450479800_ivz316-B8","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1093\/icvts\/ivz188","article-title":"Tranexamic acid and convulsive seizures after off-pump coronary artery bypass surgery: the role of renal insufficiency","volume":"29","author":"Hulde","year":"2019","journal-title":"Interact CardioVasc Thorac Surg"}],"container-title":["Interactive CardioVascular and Thoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/icvts\/article-pdf\/30\/4\/538\/32973949\/ivz316.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/icvts\/article-pdf\/30\/4\/538\/32973949\/ivz316.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,27]],"date-time":"2020-03-27T19:45:17Z","timestamp":1585338317000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/icvts\/article\/30\/4\/538\/5709878"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,21]]},"references-count":8,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2020,1,21]]},"published-print":{"date-parts":[[2020,4,1]]}},"URL":"https:\/\/doi.org\/10.1093\/icvts\/ivz316","relation":{},"ISSN":["1569-9285"],"issn-type":[{"value":"1569-9285","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,4]]},"published":{"date-parts":[[2020,1,21]]}}}