{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T08:12:04Z","timestamp":1780474324027,"version":"3.54.1"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2020,1,27]],"date-time":"2020-01-27T00:00:00Z","timestamp":1580083200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title\/>\n                  <jats:p\/>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>The use of levosimendan for paediatric patients with low cardiac output after congenital heart surgery has been recently described. We sought to evaluate ventriculo-arterial coupling (VAC) and other ventricular energetic parameters before and after 72\u2009h from levosimendan start in infants with single-ventricle physiology and cardiac failure after palliation with Norwood or hybrid procedures.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>In this single-centre retrospective study, 9 consecutive patients affected by hypoplastic left heart syndrome-like anatomy were retrospectively analysed. Systolic elastance, diastolic elastance, arterial elastance, VAC and cardiac mechanical efficiency were calculated by measuring, through 2-dimensional echocardiography, end-systolic volume and end-diastolic volume and by recording mean arterial pressure and central venous pressure.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>The median (range) weight and age were 2.8 (2.3\u20136) kg and 16.5 (6\u2013116) days, respectively. After 72\u2009h from levosimendan start, end-systolic volume significantly decreased (\u22121\u2009ml, \u22123.2 to \u22120.1, P\u2009=\u20090.007), whereas mean arterial pressure and end-diastolic volume remained stable. Heart rate showed a significant decrease (\u221228 beats\/min, \u221241 to 22, P\u2009=\u20090.008). Systolic elastance (2.9\u2009mmHg\/ml, 0.4\u20135.4, P\u2009=\u20090.008), arterial elastance (\u22125.9, \u221224 to \u22120.5, P\u2009=\u20090.038), VAC (\u22120.86, \u22121.5 to \u22120.16, P\u2009=\u20090.009) and cardiac mechanical efficiency (0.18, 0.03\u20130.22, P\u2009=\u20090.008) differences also showed significant modifications.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>In a small case series of patients with single-ventricle physiology, levosimendan showed to improve contractility and optimize VAC, with a reduction of heart rate. Monitoring of VAC and ventricular energetics can be an interesting aspect to improve the management of heart failure in infants with univentricular anatomy.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/icvts\/ivz319","type":"journal-article","created":{"date-parts":[[2019,12,23]],"date-time":"2019-12-23T20:10:19Z","timestamp":1577131819000},"page":"623-629","source":"Crossref","is-referenced-by-count":10,"title":["Effects of levosimendan on ventriculo-arterial coupling and cardiac efficiency in paediatric patients with single-ventricle physiology after surgical palliation: retrospective study"],"prefix":"10.1093","volume":"30","author":[{"given":"Roberta","family":"Iacobelli","sequence":"first","affiliation":[{"name":"Pediatric Cardiology Unit, Department of Cardiology and Cardiac Surgery, Bambino Ges\u00f9 Children\u2019s Hospital, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8916-0569","authenticated-orcid":false,"given":"Zaccaria","family":"Ricci","sequence":"first","affiliation":[{"name":"Pediatric Cardiac Intensive Care Unit, Department of Cardiology and Cardiac Surgery, Bambino Ges\u00f9 Children\u2019s Hospital, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"Marinari","sequence":"first","affiliation":[{"name":"Pediatric Cardiac Intensive Care Unit, Department of Cardiology and Cardiac Surgery, Bambino Ges\u00f9 Children\u2019s Hospital, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Haiberger","sequence":"first","affiliation":[{"name":"Pediatric Cardiac Intensive Care Unit, Department of Cardiology and Cardiac Surgery, Bambino Ges\u00f9 Children\u2019s Hospital, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arianna","family":"Di Molfetta","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery, Policlinico Universitario A. Gemelli, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Toscano","sequence":"first","affiliation":[{"name":"Pediatric Cardiology Unit, Department of Cardiology and Cardiac Surgery, Bambino Ges\u00f9 Children\u2019s Hospital, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Di Chiara","sequence":"first","affiliation":[{"name":"Pediatric Cardiac Intensive Care Unit, Department of Cardiology and Cardiac Surgery, Bambino Ges\u00f9 Children\u2019s Hospital, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,1,27]]},"reference":[{"key":"2020032715450058000_ivz319-B1","doi-asserted-by":"crossref","first-page":"58","DOI":"10.2174\/1570161113666151014125556","article-title":"Pharmacological manipulation of peripheral vascular resistance in single ventricle patients (stages I, II, and III of 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