{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T05:16:38Z","timestamp":1790054198395,"version":"4.0.1"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2020,1,28]],"date-time":"2020-01-28T00:00:00Z","timestamp":1580169600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title\/><jats:p\/><\/jats:sec><jats:sec><jats:title>OBJECTIVES<\/jats:title><jats:p>Video-assisted thoracoscopic thymectomy is becoming the preferable approach for early-stage thymoma. However, large thymomas are still recognized as a relative contraindication due to the possible risk of incomplete resection or capsular disruption. Thus, the aim of this study is to evaluate the feasibility of video-assisted thoracoscopic thymectomy for large thymomas.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Patients diagnosed with Masaoka stage I\u2013IV thymoma between April 2001 and December 2018 were retrospectively reviewed. All patients were divided into 2 groups: thymoma &amp;lt;5.0\u2009cm (group A) and thymoma \u22655.0\u2009cm (group B). Propensity score matching analysis was performed to compare postoperative results. Recurrence-free survival and overall survival were compared for oncological evaluation.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>A total of 346 patients were included in this study. In the propensity score matching analysis, 126 patients were included both in group A and group B. There was no significant difference between these 2 groups in terms of the R0 resection rate (95.2% vs 94.4%, P\u2009=\u20091.000), conversion rate (1.6% vs 3.2%, P\u2009=\u20090.684), operation time (119.4\u2009\u00b1\u200948.4 vs 139.1\u2009\u00b1\u200946.6\u2009min, P\u2009=\u20090.955), blood loss (93.2\u2009\u00b1\u2009231.7 vs 100.5\u2009\u00b1\u2009149.3\u2009ml, P\u2009=\u20090.649), duration of chest drainage (2.7\u2009\u00b1\u20091.6 vs 2.8\u2009\u00b1\u20092.0\u2009days, P\u2009=\u20090.184), length of hospitalization (5.0\u2009\u00b1\u20093.9 vs 5.2\u2009\u00b1\u20092.9\u2009days, P\u2009=\u20090.628) or postoperative complications (5.9% vs 8.5%, P\u2009=\u20090.068). There was no significant difference between these 2 groups in terms of the overall survival (P\u2009=\u20090.271) and recurrence-free survival (P\u2009=\u20090.288).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Video-assisted thoracoscopic thymectomy is a safe and effective approach for large thymomas (\u22655\u2009cm) with comparable surgical and oncological results.<\/jats:p><\/jats:sec>","DOI":"10.1093\/icvts\/ivz320","type":"journal-article","created":{"date-parts":[[2019,12,24]],"date-time":"2019-12-24T12:08:43Z","timestamp":1577189323000},"page":"565-572","source":"Crossref","is-referenced-by-count":19,"title":["Video-assisted thoracoscopic thymectomy is feasible for large thymomas: a propensity-matched comparison"],"prefix":"10.1093","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9459-2929","authenticated-orcid":false,"given":"Wenhan","family":"Weng","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery, Peking 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