{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T17:13:25Z","timestamp":1793121205534,"version":"4.5.0"},"reference-count":64,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2020,5,6]],"date-time":"2020-05-06T00:00:00Z","timestamp":1588723200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004836","name":"Danish Council for Independent Research","doi-asserted-by":"crossref","award":["DFF 4183\u201300152"],"award-info":[{"award-number":["DFF 4183\u201300152"]}],"id":[{"id":"10.13039\/501100004836","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Faculty of Health at Aarhus University","id":[{"id":"https:\/\/ror.org\/01aj84f44","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Early puberty is a risk indicator for adult diseases. Identification of modifiable causes of earlier puberty is, therefore, warranted. We estimate the association between childhood body mass index (BMI) and pubertal timing in a cohort study and in a sibling-matched study to adjust for unobserved time-stable confounders shared within families.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>For the cohort study, 11\u00a0046 of 22\u00a0439 (49%) invited\u00a0children, born 2000\u2013203, from the Danish National Birth Cohort (DNBC) had information on childhood BMI at 7\u2009years and self-reported, half-yearly puberty information from 11\u2009years on Tanner stages, menarche, voice break, first ejaculation, acne, and axillary hair. For the sibling-matched study, 1700 brothers and sisters were included among 86\u00a0820 live-born singletons from the DNBC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Childhood overweight (85th \u2264 BMI\u2009&amp;lt;\u200995th percentile) and obesity (BMI\u2009\u2265\u200995th percentile) were associated with earlier age attaining the pubertal milestones in a dose-dependent manner in boys and girls. When modelling all pubertal milestones simultaneously, the pubertal milestones were attained earlier in: overweight boys: \u22123.1 [95% confidence interval (CI): \u22124.5, \u22121.7] months, overweight girls: \u22125.5 (95% CI: \u22127.1, \u22123.9) months, obese boys: \u22123.5 (95% CI: \u22125.1, \u22122.0) months, obese girls: \u22125.2 (95% CI: \u22127.1, \u22123.4) months compared with normal weight (BMI\u2009 &amp;lt; 85th percentile) children. In the sibling-matched study, higher BMI was associated with earlier age at attaining most pubertal milestones in girls, but only a tendency toward earlier pubertal timing was observed in boys.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Childhood overweight and obesity were associated with earlier pubertal timing even after adjustment for unobserved time-stable confounders shared within families.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ije\/dyaa056","type":"journal-article","created":{"date-parts":[[2020,3,24]],"date-time":"2020-03-24T16:09:35Z","timestamp":1585066175000},"page":"834-844","source":"Crossref","is-referenced-by-count":148,"title":["Childhood overweight and obesity and timing of puberty in boys and girls: cohort and sibling-matched analyses"],"prefix":"10.1093","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1499-8401","authenticated-orcid":false,"given":"Nis","family":"Brix","sequence":"first","affiliation":[{"name":"Department of Public Health, Aarhus University, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Ernst","sequence":"additional","affiliation":[{"name":"Department of Public Health, Aarhus University, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lea Lykke Braskh\u00f8j","family":"Lauridsen","sequence":"additional","affiliation":[{"name":"Department of Public Health, Aarhus University, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik Thorlund","family":"Parner","sequence":"additional","affiliation":[{"name":"Department of Public Health, Aarhus University, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Onyebuchi A","family":"Arah","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Fielding School of Public Health, UCLA, Los Angeles, CA, USA"},{"name":"Department of Statistics, UCLA College of Letters and Science, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f8rn","family":"Olsen","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Fielding School of Public Health, UCLA, Los Angeles, CA, USA"},{"name":"Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tine Brink","family":"Henriksen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia H\u00f8st","family":"Ramlau-Hansen","sequence":"additional","affiliation":[{"name":"Department of Public Health, Aarhus University, 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