{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T21:59:28Z","timestamp":1765231168690,"version":"3.37.3"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2020,6,26]],"date-time":"2020-06-26T00:00:00Z","timestamp":1593129600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Special Emergency Project for New Coronavirus Prevention and Control in Henan Province","award":["201100310800"],"award-info":[{"award-number":["201100310800"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81972789"],"award-info":[{"award-number":["81972789"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"crossref","award":["2018ZX10302205-004-002"],"award-info":[{"award-number":["2018ZX10302205-004-002"]}],"id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100010014","name":"Six Talent Peaks Project in Jiangsu Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010014","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["JUSRP22011"],"award-info":[{"award-number":["JUSRP22011"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Technology Development Funding of Wuxi","award":["WX18IVJN017"],"award-info":[{"award-number":["WX18IVJN017"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Despite many reports on the characteristics of coronavirus disease 2019 (COVID-19) in Wuhan, China, relatively little is known about the transmission features of COVID-19 outside Wuhan, especially at the provincial level.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We collected epidemiological, demographic, clinical, laboratory, radiological and occupation information, along with contact history, of 671 patients with laboratory-confirmed COVID-19 reported from January 23 to February 5, 2020, in Henan province, China. We described characteristics of these cases, compared the diagnostic accuracy and features of blood testing, computed tomography (CT) scans and X-rays, and analysed SARS-CoV-2 transmission sources and patients\u2019 occupations in Henan province.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The mean age of patients in this case series was 43\u2009years, 56.2% were male and 22.4% had coexisting medical disorders. The death rate was 0.3%. Fourteen patients did not show any symptoms. Lymphocyte percentage was associated with disease severity (\u03c72 = 6.71, P\u2009=\u20090.035) but had a large variation in each sample group. The mean time from illness onset to diagnosis was 5.6\u2009days. A total of 330 patients had ever lived in or visited Wuhan, 150 had contact with confirmed cases, 323 had been to a hospital and 119 had been to a wet market. There were 33 patients who did not have a traceable transmission source, with 21.2% of these being farmers and 15.2% being workmen.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Lymphocyte percentage was a sign of severe COVID-19 in general but was not a good diagnostic index. Longer time from illness onset to diagnosis was associated with higher COVID-19 severity, older age, higher likelihood of having coexisting cardiovascular diseases including hypertension, and being male. Farming was found to be a high-risk occupation in Henan province, China.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ije\/dyaa081","type":"journal-article","created":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T19:10:25Z","timestamp":1587409825000},"page":"1085-1095","source":"Crossref","is-referenced-by-count":15,"title":["Epidemiological and clinical characteristics of 671 COVID-19 patients in Henan Province, China"],"prefix":"10.1093","volume":"49","author":[{"given":"Yifei","family":"Nie","sequence":"first","affiliation":[{"name":"Henan Center for Disease Control and Prevention\/Henan Key Laboratory of Pathogenic Microorganisms, Zhengzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jitian","family":"Li","sequence":"additional","affiliation":[{"name":"Henan Provincial Orthopedic Institute, Zhengzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueyong","family":"Huang","sequence":"additional","affiliation":[{"name":"Henan Center for Disease Control and Prevention\/Henan Key Laboratory of Pathogenic Microorganisms, Zhengzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanshen","family":"Guo","sequence":"additional","affiliation":[{"name":"Henan Center for Disease Control and Prevention\/Henan Key Laboratory of Pathogenic Microorganisms, Zhengzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaobai","family":"Zhang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Ma","sequence":"additional","affiliation":[{"name":"Henan Provincial Orthopedic Institute, Zhengzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haifeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Henan Center for Disease Control and Prevention\/Henan Key Laboratory of Pathogenic Microorganisms, Zhengzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muge","family":"Qi","sequence":"additional","affiliation":[{"name":"Henan Center for Disease Control and Prevention\/Henan Key Laboratory of Pathogenic Microorganisms, Zhengzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyan","family":"Tang","sequence":"additional","affiliation":[{"name":"Henan Center for Disease Control and Prevention\/Henan Key Laboratory of Pathogenic Microorganisms, Zhengzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojing","family":"Shen","sequence":"additional","affiliation":[{"name":"Henan Center for Disease Control and Prevention\/Henan Key Laboratory of Pathogenic Microorganisms, Zhengzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofeng","family":"Dai","sequence":"additional","affiliation":[{"name":"Wuxi School of Medicine, Jiangnan University, Wuxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,6,26]]},"reference":[{"key":"2020111211324296800_OP-B1","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1056\/NEJMoa2001017","article-title":"A novel coronavirus from patients with pneumonia in China, 2019","volume":"382","author":"Zhu","year":"2020","journal-title":"N Engl J Med"},{"key":"2020111211324296800_OP-B2","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0140-6736(20)30183-5","article-title":"Clinical features of patients infected with 2019 novel coronavirus in Wuhan, 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