{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:16:24Z","timestamp":1790946984346,"version":"4.1.0"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T00:00:00Z","timestamp":1601251200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Italian Association of Cancer Research"},{"DOI":"10.13039\/501100005010","name":"AIRC","doi-asserted-by":"publisher","award":["21879"],"award-info":[{"award-number":["21879"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["801520 HP-JA-2017"],"award-info":[{"award-number":["801520 HP-JA-2017"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Innovative Partnership for Action Against Cancer","award":["2010.1354"],"award-info":[{"award-number":["2010.1354"]}]},{"DOI":"10.13039\/501100002803","name":"Cariplo Foundation","doi-asserted-by":"publisher","award":["2010\u20131984"],"award-info":[{"award-number":["2010\u20131984"]}],"id":[{"id":"10.13039\/501100002803","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Few studies have estimated the probability of being cured for cancer patients. This study aims to estimate population-based indicators of cancer cure in Europe by type, sex, age and period.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>7.2 million cancer patients (42 population-based cancer registries in 17 European countries) diagnosed at ages 15\u201374 years in 1990\u20132007 with follow-up to 2008 were selected from the EUROCARE-5 dataset. Mixture-cure models were used to estimate: (i) life expectancy of fatal cases (LEF); (ii) cure fraction (CF) as proportion of patients with same death rates as the general population; (iii) time to cure (TTC) as time to reach 5-year conditional relative survival (CRS) &amp;gt;95%.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>LEF ranged from 10\u2009years for chronic lymphocytic leukaemia patients to &amp;lt;6\u2009months for those with liver, pancreas, brain, gallbladder and lung cancers. It was 7.7\u2009years for patients with prostate cancer at age 65\u201374\u2009years and &amp;gt;5\u2009years for women with breast cancer. The CF was 94% for testis, 87% for thyroid cancer in women and 70% in men, 86% for skin melanoma in women and 76% in men, 66% for breast, 63% for prostate and &amp;lt;10% for liver, lung and pancreatic cancers. TTC was &amp;lt;5\u2009years for testis and thyroid cancer patients diagnosed below age 55\u2009years, and &amp;lt;10\u2009years for stomach, colorectal, corpus uteri and melanoma patients of all ages. For breast and prostate cancers, a small excess (CRS\u2009&amp;lt;\u200995%) remained for at least 15\u2009years.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Estimates from this analysis should help to reduce unneeded medicalization and costs. They represent an opportunity to improve patients\u2019 quality of life.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ije\/dyaa128","type":"journal-article","created":{"date-parts":[[2020,7,2]],"date-time":"2020-07-02T11:07:52Z","timestamp":1593688072000},"page":"1517-1525","source":"Crossref","is-referenced-by-count":85,"title":["Cancer cure for 32 cancer types: results from the EUROCARE-5 study"],"prefix":"10.1093","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6163-200X","authenticated-orcid":false,"given":"Luigino","family":"Dal Maso","sequence":"first","affiliation":[{"name":"Cancer Epidemiology Unit, Centro di Riferimento Oncologico (CRO), IRCCS, Aviano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Panato","sequence":"additional","affiliation":[{"name":"Cancer Epidemiology Unit, Centro di Riferimento Oncologico (CRO), IRCCS, Aviano, 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Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemma","family":"Gatta","sequence":"additional","affiliation":[{"name":"Evaluative Epidemiology Unit, Research Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Gigli","sequence":"additional","affiliation":[{"name":"Institute for Research on Population and Social Policies, National Research Council, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Giusti","sequence":"additional","affiliation":[{"name":"European Commission, Joint Research Centre (JRC), Ispra, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"Jooste","sequence":"additional","affiliation":[{"name":"Registre Bourguignon des Cancers Digestifs, INSERM UMR 1231, CHU de Dijon, Universit\u00e9 de Bourgogne, Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Minicozzi","sequence":"additional","affiliation":[{"name":"Analytical Epidemiology and Health Impact Unit, Research Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy"},{"name":"Cancer Survival Group, Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana","family":"Neamtiu","sequence":"additional","affiliation":[{"name":"European Commission, Joint Research Centre (JRC), Ispra, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ga\u00eblle","family":"Romain","sequence":"additional","affiliation":[{"name":"Registre Bourguignon des Cancers Digestifs, INSERM UMR 1231, CHU de Dijon, Universit\u00e9 de Bourgogne, Dijon, 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