{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T16:14:08Z","timestamp":1790439248421,"version":"4.1.0"},"reference-count":70,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2021,3,15]],"date-time":"2021-03-15T00:00:00Z","timestamp":1615766400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"The NutriNet-Sant"},{"name":"French Ministry of Health (DGS), Sant\u00e9 Publique France"},{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Medical Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"crossref"}]},{"name":"French National Research Institute for Agriculture"},{"name":"Food and Environment"},{"DOI":"10.13039\/501100013943","name":"National Conservatory of Arts and Crafts","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100013943","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Sorbonne Paris Nord University"},{"DOI":"10.13039\/501100001665","name":"French National Research Agency","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Syst\u00e8mes Alimentaires Durables","award":["ANR-13-ALID-0001"],"award-info":[{"award-number":["ANR-13-ALID-0001"]}]},{"name":"Sorbonne Paris Nord University"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,8,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Some pesticides, used in large quantities in current agricultural practices all over Europe, are suspected of adverse effects on human reproductive health (breast and prostate cancers), through mechanisms of endocrine disruption and possible carcinogenic properties, as observed in agricultural settings. However, evidence on dietary pesticide exposure and breast cancer (BC) is lacking for the general population. We aimed to assess the associations between dietary exposure to pesticides and BC risk among postmenopausal women of the NutriNet-Sant\u00e9 cohort.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In 2014, participants completed a self-administered semi-quantitative food-frequency questionnaire distinguishing conventional and organic foods. Exposures to 25 active substances used in EU plant-protection products were estimated using a pesticide-residue database accounting for farming practices, from Chemisches und Veterin\u00e4runtersuchungsamt Stuttgart, Germany. Non-negative matrix factorization (NMF), adapted for data with excess zeros, was used to establish exposure profiles. The four extracted NMF components\u2019 quintiles were introduced into Cox models estimating hazard ratio (HR) and 95% confidence interval (95% CI), adjusted for known confounding factors.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 13\u2009149 postmenopausal women were included in the analysis (169 BC cases, median follow-up\u2009=\u20094.83\u2009years). Negative associations between Component 3, reflecting low exposure to synthetic pesticides, and postmenopausal BC risk were found [HRQ5\u2009=\u20090.57; 95% CI (0.34; 0.93), p-trend\u2009=\u20090.006]. Positive association between Component 1 score (highly correlated to chlorpyrifos, imazalil, malathion, thiabendazole) and postmenopausal BC risk was found specifically among overweight and obese women [HRQ5\u2009=\u20094.13; 95% CI (1.50; 11.44), p-trend\u2009=\u20090.006]. No associations were detected for the other components.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>These associations suggest a potential role of dietary pesticide exposure on BC risk. Further research is needed to investigate the mechanisms and confirm these results in other populations.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ije\/dyab015","type":"journal-article","created":{"date-parts":[[2021,1,27]],"date-time":"2021-01-27T20:09:59Z","timestamp":1611778199000},"page":"1184-1198","source":"Crossref","is-referenced-by-count":46,"title":["Prospective association between dietary pesticide exposure profiles and postmenopausal breast-cancer risk in the NutriNet-Sant\u00e9 cohort"],"prefix":"10.1093","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7270-6032","authenticated-orcid":false,"given":"Pauline","family":"Rebouillat","sequence":"first","affiliation":[{"name":"Sorbonne Paris Nord University, INSERM, INRAE, CNAM, Nutritional Epidemiology Research Team (EREN), Epidemiology and Statistics Research Center\u2014University of Paris (CRESS), 93017, Bobigny, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3407-1646","authenticated-orcid":false,"given":"Rodolphe","family":"Vidal","sequence":"additional","affiliation":[{"name":"Institut de l\u2019Agriculture et de l\u2019Alimentation Biologiques (ITAB), Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Pierre","family":"Cravedi","sequence":"additional","affiliation":[{"name":"Toxalim (Research Centre in Food Toxicology), Universit\u00e9 de Toulouse, INRAE, ENVT, INP-Purpan, UPS, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Taupier-Letage","sequence":"additional","affiliation":[{"name":"Institut de l\u2019Agriculture et de l\u2019Alimentation Biologiques (ITAB), Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Debrauwer","sequence":"additional","affiliation":[{"name":"Toxalim (Research Centre in Food Toxicology), Universit\u00e9 de Toulouse, INRAE, ENVT, INP-Purpan, UPS, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Gamet-Payrastre","sequence":"additional","affiliation":[{"name":"Toxalim (Research Centre in Food Toxicology), Universit\u00e9 de Toulouse, INRAE, ENVT, INP-Purpan, UPS, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathilde","family":"Touvier","sequence":"additional","affiliation":[{"name":"Sorbonne Paris Nord University, INSERM, INRAE, CNAM, Nutritional Epidemiology Research Team (EREN), Epidemiology and Statistics Research Center\u2014University of Paris (CRESS), 93017, Bobigny, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8322-8857","authenticated-orcid":false,"given":"M\u00e9lanie","family":"Deschasaux-Tanguy","sequence":"additional","affiliation":[{"name":"Sorbonne Paris Nord University, INSERM, INRAE, CNAM, Nutritional Epidemiology Research Team (EREN), Epidemiology and Statistics Research Center\u2014University of Paris (CRESS), 93017, Bobigny, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paule","family":"Latino-Martel","sequence":"additional","affiliation":[{"name":"Sorbonne Paris Nord University, INSERM, INRAE, CNAM, Nutritional Epidemiology Research Team (EREN), Epidemiology and Statistics Research Center\u2014University of Paris (CRESS), 93017, Bobigny, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serge","family":"Hercberg","sequence":"additional","affiliation":[{"name":"Sorbonne Paris Nord University, INSERM, INRAE, CNAM, Nutritional Epidemiology Research Team (EREN), Epidemiology and Statistics Research Center\u2014University of Paris (CRESS), 93017, Bobigny, France"},{"name":"D\u00e9partement de Sant\u00e9 Publique, H\u00f4pital Avicenne, 93017 Bobigny, 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