{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T01:55:44Z","timestamp":1788314144802,"version":"build-2803163510"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2021,5,31]],"date-time":"2021-05-31T00:00:00Z","timestamp":1622419200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"WHO Collaborating Centre for Reference and Research on Influenza"},{"DOI":"10.13039\/501100003921","name":"Australian Government Department of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003921","id-type":"DOI","asserted-by":"publisher"}]},{"name":"DHB Foundation"},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,11,10]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Infectious diseases are a leading cause of hospitalization during childhood. The various mitigation strategies implemented to control the coronavirus disease (COVID-19) pandemic could have additional, unintended benefits for limiting the spread of other infectious diseases and their associated burden on the health care system.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We conducted an interrupted time-series analysis using population-wide hospitalization data for the state of Victoria, Australia. Infection-related hospitalizations for children and adolescents (aged &lt;18\u2009years, total source population \u223c1.4 million) were extracted using pre-defined International Classification of Diseases 10th Revision Australian Modification (ICD-10-AM) codes. The change in weekly hospitalization rates (incidence rate ratio, IRR) for all infections following the introduction of pandemic-related restrictions from 15 March 2020 was estimated.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Over 2015\u201319, the mean annual incidence of hospitalization with infection among children less than 18\u2009years was 37 per 1000 population. There was an estimated 65% (95% CI 62-67%) reduction in the incidence of overall infection-related hospitalizations associated with the introduction of pandemic restrictions. The reduction was most marked in younger children (at least 66% in those less than 5\u2009years of age) and for lower respiratory tract infections (relative reduction 85%, 95% CI 85-86%).<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n The wider impacts of pandemic mitigation strategies on non-COVID-19 infection-related hospitalizations are poorly understood. We observed marked and rapid decreases in hospitalized childhood infection. In tandem with broader consequences, sustainable measures, such as improved hand hygiene, could reduce the burden of severe childhood infection post-pandemic and the social and economic costs of hospitalization.<\/jats:p>\n <\/jats:sec>","DOI":"10.1093\/ije\/dyab101","type":"journal-article","created":{"date-parts":[[2021,4,20]],"date-time":"2021-04-20T13:30:25Z","timestamp":1618925425000},"page":"1435-1443","source":"Crossref","is-referenced-by-count":23,"title":["Changes in infection-related hospitalizations in children following pandemic restrictions: an interrupted time-series analysis of total population data"],"prefix":"10.1093","volume":"50","author":[{"given":"Isobel M F","family":"Todd","sequence":"first","affiliation":[{"name":"COVID-19 Public Health Division, Victorian Department of Health, Melbourne, VIC, Australia"},{"name":"Melbourne School of Population and Global Heath, University of Melbourne, Parkville, VIC, Australia"},{"name":"Murdoch Children\u2019s Research Institute, Royal Children\u2019s Hospital, Parkville, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica E","family":"Miller","sequence":"additional","affiliation":[{"name":"Murdoch Children\u2019s Research Institute, Royal Children\u2019s Hospital, Parkville, VIC, Australia"},{"name":"Department of Paediatrics, University of Melbourne, Parkville, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacey L","family":"Rowe","sequence":"additional","affiliation":[{"name":"COVID-19 Public Health Division, Victorian Department of Health, Melbourne, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8304-4302","authenticated-orcid":false,"given":"David P","family":"Burgner","sequence":"additional","affiliation":[{"name":"Murdoch Children\u2019s Research Institute, Royal Children\u2019s Hospital, Parkville, VIC, Australia"},{"name":"Department of Paediatrics, University of Melbourne, Parkville, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0856-0294","authenticated-orcid":false,"given":"Sheena G","family":"Sullivan","sequence":"additional","affiliation":[{"name":"COVID-19 Public Health Division, Victorian Department of Health, Melbourne, VIC, Australia"},{"name":"Melbourne School of Population and Global Heath, University of Melbourne, Parkville, VIC, Australia"},{"name":"WHO Collaborating Centre for Reference and Research on Influenza, Royal Melbourne Hospital, and Department of Infectious Diseases, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, 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