{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T01:38:17Z","timestamp":1785289097460,"version":"3.55.0"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2021,10,18]],"date-time":"2021-10-18T00:00:00Z","timestamp":1634515200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["2018\u201302640"],"award-info":[{"award-number":["2018\u201302640"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Swedish Initiative for Research on Microdata in the Social And Medical Sciences","award":["340\u20132013-5867"],"award-info":[{"award-number":["340\u20132013-5867"]}]},{"name":"Stockholm County Council"},{"name":"Strategic Research Program in Epidemiology at Karolinska Institutet"},{"name":"Swedish Heart-Lung Foundation and the Swedish Asthma and Allergy Association\u2019s Research Foundation"},{"name":"Stavanger University Hospital: a study sabbatical from the Paediatric Department"},{"name":"Department of Research and the Research Group for Paediatric Health"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,6,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>We aimed to study whether pre-eclampsia is associated with childhood asthma, allergic and non-allergic asthma, accounting for family factors and intermediate variables.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The study population comprised 779 711 children born in 2005\u20132012, identified from Swedish national health registers (n\u2009=\u200914 823\/7410 exposed to mild\/moderate and severe pre-eclampsia, respectively). We used Cox regression to estimate the associations of mild\/moderate and severe pre-eclampsia with incident asthma, before and after age 2\u2009years. Cox regressions were controlled for familial factors using sibling comparisons, then stratified on high and low risk for intermediate variables: caesarean section, prematurity and small for gestational age. We used logistic regression for allergic and non-allergic prevalent asthma at 6\u2009years as a measure of more established asthma.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The incidence of asthma in children was 7.7% (n\u2009=\u200960 239). The associations varied from adjusted hazard ratio (adjHR) 1.11, 95% confidence interval (CI): 1.00, 1.24 for mild\/moderate pre-eclampsia and asthma at &amp;gt;2\u2009years age, to adjHR 1.78, 95% CI: 1.64, 1.95 for severe pre-eclampsia and asthma at &amp;lt;2\u2009years age. Sibling comparisons attenuated most estimates except for the association between severe pre-eclampsia and asthma at &amp;lt;2\u2009years age (adjHR 1.45, 95% CI: 1.10, 1.90), which also remained when stratifying for the risk of intermediates. Mild\/moderate and severe pre-eclampsia were associated with prevalent non-allergic (but not allergic) asthma at 6\u2009years, with adjusted odds ratio (adjOR) 1.17, 95% CI: 1.00, 1.36 and adjOR 1.51, 95% CI: 1.23, 1.84, respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>We found evidence that severe, but not mild\/moderate, pre-eclampsia is associated with asthma regardless of familial factors and confounders.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ije\/dyab204","type":"journal-article","created":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T20:24:57Z","timestamp":1633119897000},"page":"749-758","source":"Crossref","is-referenced-by-count":9,"title":["Pre-eclampsia and risk of early-childhood asthma: a register study with sibling comparison and an exploration of intermediate variables"],"prefix":"10.1093","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4529-2196","authenticated-orcid":false,"given":"Kristine Kjer","family":"Byberg","sequence":"first","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics, Karolinska Institutet , Sweden"},{"name":"Pediatric Clinic, Stavanger University Hospital , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Lundholm","sequence":"additional","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics, Karolinska Institutet , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bronwyn K","family":"Brew","sequence":"additional","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics, Karolinska Institutet , Sweden"},{"name":"National Perinatal Epidemiology and Statistics Unit, Centre for Big Data Research in Health and School of Women and Children\u2019s Health, University of New South Wales , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustaf","family":"Rejn\u00f6","sequence":"additional","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics, Karolinska Institutet , Sweden"},{"name":"Obstetrics and Gynaecology Unit , S\u00f6dersjukhuset, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catarina","family":"Almqvist","sequence":"additional","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics, Karolinska Institutet , Sweden"},{"name":"Pediatric Allergy and Pulmonology Unit, Astrid Lindgren Children\u2019s Hospital at Karolinska University Hospital , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,10,18]]},"reference":[{"key":"2022061309573410500_dyab204-B1","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/S0140-6736(06)69283-0","article-title":"Worldwide time trends in the 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