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In the present study, we aimed to clarify the causal relationship between ADHD and a comprehensive range of related traits.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We used genome-wide association study (GWAS) summary statistics for ADHD (n\u2009=\u200953\u200a293) and 124 traits related to anthropometry, cognitive function and intelligence, early life exposures, education and employment, lifestyle and environment, longevity, neurological, and psychiatric and mental health or personality and psychosocial factors available in the MR-Base database (16\u200a067 \u2264n\u2009\u2264766\u200a345). To investigate their causal relationship with ADHD, we used two-sample Mendelian randomization (MR) with a range of sensitivity analyses, and validated MR findings using causal analysis using summary effect estimates (CAUSE), aiming to avoid potential false-positive results.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Our findings strengthen previous evidence of a causal effect of ADHD liability on smoking and major depression, and are consistent with a causal effect on odds of decreased average total household income [odds ratio (OR)\u2009=\u20090.966, 95% credible interval (CrI)\u2009=\u2009(0.954, 0.979)] and increased lifetime number of sexual partners [OR\u2009=\u20091.023, 95% CrI\u2009=\u2009(1.013, 1.033)]. We also found evidence for a causal effect on ADHD for liability of arm predicted mass and weight [OR\u2009=\u20091.452, 95% CrI\u2009=\u2009(1.307, 1.614) and OR\u2009=\u20091.430, 95% CrI\u2009=\u2009(1.326, 1.539), respectively] and time spent watching television [OR\u2009=\u20091.862, 95% CrI\u2009=\u2009(1.545, 2.246)], and evidence for a bidirectional effect for age of first sexual intercourse [beta\u2009=\u2009\u22120.058, 95% CrI\u2009=\u2009(\u22120.072, \u22120.044) and OR\u2009=\u20090.413, 95% CrI\u2009=\u2009(0.372, 0.457), respectively], odds of decreased age completed full-time education [OR\u2009=\u20090.972, 95% CrI\u2009=\u2009(0.962, 0.981) and OR\u2009=\u20090.435, 95% CrI\u2009=\u2009(0.356, 0.533), respectively] and years of schooling [beta\u2009=\u2009-0.036, 95% CrI\u2009=\u2009(\u22120.048, \u22120.024) and OR\u2009=\u20090.458, 95% CrI\u2009=\u2009(0.411, 0.511), respectively].<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Our results may contribute to explain part of the widespread co-occurring traits and comorbid disorders across the lifespan of individuals with ADHD and may open new opportunities for developing preventive strategies for ADHD and for negative ADHD trajectories.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ije\/dyac128","type":"journal-article","created":{"date-parts":[[2022,6,12]],"date-time":"2022-06-12T16:04:15Z","timestamp":1655049855000},"page":"386-402","source":"Crossref","is-referenced-by-count":32,"title":["Mendelian randomization analysis for attention deficit\/hyperactivity disorder: studying a broad range of exposures and outcomes"],"prefix":"10.1093","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3213-1107","authenticated-orcid":false,"given":"Mar\u00eda","family":"Soler Artigas","sequence":"first","affiliation":[{"name":"Psychiatric Genetics Unit, Group of Psychiatry, Mental 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Madrid, Spain"},{"name":"Department of Genetics, Microbiology, and Statistics, Faculty of Biology, Universitat de Barcelona , Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Rovira","sequence":"additional","affiliation":[{"name":"Psychiatric Genetics Unit, Group of Psychiatry, Mental Health and Addiction, Vall d'Hebron Research Institute (VHIR), Universitat Aut\u00f2noma de Barcelona , Barcelona, Spain"},{"name":"Department of Mental Health, Hospital Universitari Vall d'Hebron , Barcelona, Spain"},{"name":"Vicerectorat de Recerca, postdoctoral researcher Margarita Salas, Universitat de Barcelona , Barcelona, Spain"},{"name":"Departament of Psychiatry, Faculty of Medicine, Universidad de Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Vilar-Rib\u00f3","sequence":"additional","affiliation":[{"name":"Psychiatric Genetics Unit, Group of Psychiatry, Mental Health and Addiction, Vall d'Hebron Research Institute (VHIR), Universitat Aut\u00f2noma de Barcelona , Barcelona, Spain"},{"name":"Department of Mental Health, Hospital Universitari Vall d'Hebron , Barcelona, Spain"},{"name":"Biomedical Network Research Centre on Mental Health (CIBERSAM), Instituto de Salud Carlos III , Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep Antoni","family":"Ramos-Quiroga","sequence":"additional","affiliation":[{"name":"Psychiatric Genetics Unit, Group of Psychiatry, Mental Health and Addiction, Vall d'Hebron Research Institute (VHIR), Universitat Aut\u00f2noma de Barcelona , Barcelona, Spain"},{"name":"Department of Mental Health, Hospital Universitari Vall d'Hebron , Barcelona, Spain"},{"name":"Biomedical Network Research Centre on Mental Health (CIBERSAM), Instituto de Salud Carlos III , Madrid, Spain"},{"name":"Department of Psychiatry and Forensic Medicine, Universitat Aut\u00f2noma de Barcelona , Barcelona, 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