{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:30:12Z","timestamp":1791318612471,"version":"4.3.1"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2022,8,13]],"date-time":"2022-08-13T00:00:00Z","timestamp":1660348800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["222097\/Z\/20\/Z"],"award-info":[{"award-number":["222097\/Z\/20\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018645","name":"MRC","doi-asserted-by":"publisher","award":["MR\/V015757\/1"],"award-info":[{"award-number":["MR\/V015757\/1"]}],"id":[{"id":"10.13039\/100018645","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018645","name":"MRC","doi-asserted-by":"publisher","award":["MC_PC-20059"],"award-info":[{"award-number":["MC_PC-20059"]}],"id":[{"id":"10.13039\/100018645","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018645","name":"MRC","doi-asserted-by":"publisher","award":["MR\/W016729\/1"],"award-info":[{"award-number":["MR\/W016729\/1"]}],"id":[{"id":"10.13039\/100018645","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006662","name":"NIHR","doi-asserted-by":"publisher","award":["NIHR135559"],"award-info":[{"award-number":["NIHR135559"]}],"id":[{"id":"10.13039\/100006662","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023699","name":"Health Data Research UK","doi-asserted-by":"crossref","award":["HDRUK2021.000, 2021.0157"],"award-info":[{"award-number":["HDRUK2021.000, 2021.0157"]}],"id":[{"id":"10.13039\/501100023699","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100018298","name":"Bennett Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018298","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Oxford Biomedical Research Centre"},{"name":"Wellcome Senior Research Fellowship","award":["220283\/Z\/20\/Z"],"award-info":[{"award-number":["220283\/Z\/20\/Z"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,12,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Ethnic differences in the risk of severe COVID-19 may be linked to household composition. We quantified the association between household composition and risk of severe COVID-19 by ethnicity for older individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>With the approval of NHS England, we analysed ethnic differences in the association between household composition and severe COVID-19 in people aged 67 or over in England. We defined households by number of age-based generations living together, and used multivariable Cox regression stratified by location and wave of the pandemic and accounted for age, sex, comorbidities, smoking, obesity, housing density and deprivation. We included 2\u200a692\u200a223 people over 67\u2009years in Wave 1 (1 February 2020\u201331 August 2020) and 2 731 427 in Wave 2 (1 September 2020\u201331 January 2021).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Multigenerational living was associated with increased risk of severe COVID-19 for White and South Asian older people in both waves [e.g. Wave 2, 67+ living with three other generations vs 67+-year-olds only: White hazard ratio (HR) 1.61 95% CI 1.38\u20131.87, South Asian HR 1.76 95% CI 1.48\u20132.10], with a trend for increased risks of severe COVID-19 with increasing generations in Wave 2. There was also an increased risk of severe COVID-19 in Wave 1 associated with living alone for White (HR 1.35 95% CI 1.30\u20131.41), South Asian (HR 1.47 95% CI 1.18\u20131.84) and Other (HR 1.72 95% CI 0.99\u20132.97) ethnicities, an effect that persisted for White older people in Wave 2.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Both multigenerational living and living alone were associated with severe COVID-19 in older adults. Older South Asian people are over-represented within multigenerational households in England, especially in the most deprived settings, whereas a substantial proportion of White older people live alone. The number of generations in a household, number of occupants, ethnicity and deprivation status are important considerations in the continued roll-out of COVID-19 vaccination and targeting of interventions for future pandemics.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ije\/dyac158","type":"journal-article","created":{"date-parts":[[2022,8,13]],"date-time":"2022-08-13T12:27:29Z","timestamp":1660393649000},"page":"1745-1760","source":"Crossref","is-referenced-by-count":19,"title":["Association between household composition and severe COVID-19 outcomes in older people by ethnicity: an observational cohort study using the OpenSAFELY platform"],"prefix":"10.1093","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2335-9641","authenticated-orcid":false,"given":"Kevin","family":"Wing","sequence":"first","affiliation":[{"name":"Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine , London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J","family":"Grint","sequence":"additional","affiliation":[{"name":"Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine , London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohini","family":"Mathur","sequence":"additional","affiliation":[{"name":"Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine , London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamish P","family":"Gibbs","sequence":"additional","affiliation":[{"name":"Department of Geography, University College London , London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Hickman","sequence":"additional","affiliation":[{"name":"The DataLab, University of Oxford Nuffield Department of Primary Care Health Sciences , Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Nightingale","sequence":"additional","affiliation":[{"name":"Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine , London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Schultze","sequence":"additional","affiliation":[{"name":"Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine , London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harriet","family":"Forbes","sequence":"additional","affiliation":[{"name":"Population Health Sciences, University of Bristol , Bristol, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0160-217X","authenticated-orcid":false,"given":"Vah\u00e9","family":"Nafilyan","sequence":"additional","affiliation":[{"name":"Health Modelling Hub, Office of National Statistics , Newport, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishnan","family":"Bhaskaran","sequence":"additional","affiliation":[{"name":"Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine , London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6905-876X","authenticated-orcid":false,"given":"Elizabeth","family":"Williamson","sequence":"additional","affiliation":[{"name":"Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine , London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"House","sequence":"additional","affiliation":[{"name":"Department of Mathematics, University of Manchester , Manchester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Pellis","sequence":"additional","affiliation":[{"name":"Department of Mathematics, University of Manchester , Manchester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Herrett","sequence":"additional","affiliation":[{"name":"Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine , London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nileesa","family":"Gautam","sequence":"additional","affiliation":[{"name":"Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine , London, UK"},{"name":"Aetion Inc , Boston, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3429-9576","authenticated-orcid":false,"given":"Helen J","family":"Curtis","sequence":"additional","affiliation":[{"name":"The DataLab, University of Oxford Nuffield Department of Primary Care Health Sciences , Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher T","family":"Rentsch","sequence":"additional","affiliation":[{"name":"Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine , London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angel Y S","family":"Wong","sequence":"additional","affiliation":[{"name":"Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine , London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"MacKenna","sequence":"additional","affiliation":[{"name":"The DataLab, University of Oxford Nuffield Department of Primary Care Health Sciences , Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Mehrkar","sequence":"additional","affiliation":[{"name":"The DataLab, University of Oxford Nuffield Department of Primary Care Health Sciences , Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seb","family":"Bacon","sequence":"additional","affiliation":[{"name":"The DataLab, University of Oxford Nuffield Department of Primary Care Health Sciences , Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian J","family":"Douglas","sequence":"additional","affiliation":[{"name":"Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine , London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J W","family":"Evans","sequence":"additional","affiliation":[{"name":"Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine , London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurie","family":"Tomlinson","sequence":"additional","affiliation":[{"name":"Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine , London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5127-4728","authenticated-orcid":false,"given":"Ben","family":"Goldacre","sequence":"additional","affiliation":[{"name":"The DataLab, University of Oxford Nuffield Department of Primary Care Health Sciences , Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosalind M","family":"Eggo","sequence":"additional","affiliation":[{"name":"The DataLab, University of Oxford Nuffield Department of Primary Care Health Sciences , Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,8,13]]},"reference":[{"key":"2023040221104575700_","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1093\/cid\/ciaa450","article-title":"Characteristics of household transmission of COVID-19","volume":"71","author":"Li","year":"2020","journal-title":"Clin Infect Dis"},{"key":"2023040221104575700_","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/S1473-3099(20)30471-0","article-title":"Household secondary attack rate of COVID-19 and associated determinants in Guangzhou, China: a retrospective cohort study","volume":"20","author":"Jing","year":"2020","journal-title":"Lancet Infect Dis"},{"key":"2023040221104575700_","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/S1473-3099(20)30981-6","article-title":"Household transmission of SARS-CoV-2 and risk factors for susceptibility and infectivity in Wuhan: a retrospective observational study","volume":"21","author":"Li","year":"2021","journal-title":"Lancet Infect Dis"},{"key":"2023040221104575700_","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.tim.2015.10.012","article-title":"Household transmission of influenza virus","volume":"24","author":"Tsang","year":"2016","journal-title":"Trends Microbiol"},{"key":"2023040221104575700_","doi-asserted-by":"crossref","first-page":"e1007589","DOI":"10.1371\/journal.pcbi.1007589","article-title":"Fine-scale family structure shapes influenza transmission risk in households: insights from primary schools in Matsumoto city, 2014\/15","volume":"15","author":"Endo","year":"2019","journal-title":"PLoS Comput Biol"},{"key":"2023040221104575700_","doi-asserted-by":"crossref","first-page":"e80","DOI":"10.1016\/S2666-7568(20)30016-7","article-title":"Residential context and COVID-19 mortality among adults aged 70 years and older in Stockholm: a population-based, observational study using individual-level data","volume":"1","author":"Brand\u00e9n","year":"2020","journal-title":"Lancet Healthy Longev"},{"key":"2023040221104575700_","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1093\/aje\/kwab057","article-title":"Disparities in coronavirus disease 2019 mortality by country of birth in Stockholm, Sweden: a total-population-based cohort study","volume":"190","author":"Rostila","year":"2021","journal-title":"Am J Epidemiol"},{"key":"2023040221104575700_","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1080\/08959420.2020.1770031","article-title":"Intergenerational relationships, family caregiving policy, and COVID-19 in the United States","volume":"32","author":"Stokes","year":"2020","journal-title":"J Aging Soc Policy"},{"key":"2023040221104575700_","doi-asserted-by":"crossref","first-page":"m3181","DOI":"10.1136\/bmj.m3181","article-title":"Covid-19: breaking the chain of household transmission","volume":"370","author":"Haroon","year":"2020","journal-title":"BMJ"},{"key":"2023040221104575700_","doi-asserted-by":"crossref","first-page":"19116","DOI":"10.1073\/pnas.2008581117","article-title":"No clear association emerges between intergenerational relationships and COVID-19 fatality rates from macro-level analyses","volume":"117","author":"Arpino","year":"2020","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2023040221104575700_","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1177\/0141076821999973","article-title":"Ethnicity, household composition and COVID-19 mortality: a national linked data study","volume":"114","author":"Nafilyan","year":"2021","journal-title":"J R Soc Med"},{"key":"2023040221104575700_","doi-asserted-by":"crossref","first-page":"n628","DOI":"10.1136\/bmj.n628","article-title":"Association between living with children and outcomes from covid-19: OpenSAFELY cohort study of 12 million adults in England","volume":"372","author":"Forbes","year":"2021","journal-title":"BMJ"},{"key":"2023040221104575700_","author":"Schultze","year":"2021"},{"key":"2023040221104575700_","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/s41586-020-2521-4","article-title":"Factors associated with COVID-19-related death using OpenSAFELY","volume":"584","author":"Williamson","year":"2020","journal-title":"Nature"},{"key":"2023040221104575700_","doi-asserted-by":"crossref","first-page":"2100256","DOI":"10.2807\/1560-7917.ES.2021.26.11.2100256","article-title":"Case fatality risk of the SARS-CoV-2 variant of concern B.1.1.7 in England, 16 November to 5 February","volume":"26","author":"Grint","year":"2021","journal-title":"Eurosurveillance"},{"key":"2023040221104575700_","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1177\/01410768211073923","article-title":"Association between household size and COVID-19: a UK Biobank observational study","volume":"115","author":"Gillies","year":"2022","journal-title":"J R Soc Med"},{"key":"2023040221104575700_","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1016\/S0140-6736(21)00634-6","article-title":"Ethnic differences in SARS-CoV-2 infection and COVID-19-related hospitalisation, intensive care unit admission, and death in 17 million adults in England: an observational cohort study using the OpenSAFELY platform","volume":"397","author":"Mathur","year":"2021","journal-title":"Lancet"},{"key":"2023040221104575700_","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1093\/ije\/dyaa208","article-title":"Ethnic-minority groups in England and Wales\u2014factors associated with the size and timing of elevated COVID-19 mortality: a retrospective cohort study linking census and death records","volume":"49","author":"Ayoubkhani","year":"2020","journal-title":"Int J Epidemiol"},{"key":"2023040221104575700_","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1186\/s12916-020-01640-8","article-title":"Ethnic and socioeconomic differences in SARS-CoV-2 infection: prospective cohort study using UK Biobank","volume":"18","author":"Niedzwiedz","year":"2020","journal-title":"BMC Med"},{"key":"2023040221104575700_","doi-asserted-by":"crossref","first-page":"88","DOI":"10.12688\/wellcomeopenres.15922.2","article-title":"Black, Asian and Minority Ethnic groups in England are at increased risk of death from COVID-19: indirect standardisation of NHS mortality data","volume":"5","author":"Aldridge","year":"2020","journal-title":"Wellcome Open Res"},{"key":"2023040221104575700_","doi-asserted-by":"crossref","first-page":"100109","DOI":"10.1016\/j.lanepe.2021.100109","article-title":"Factors associated with deaths due to COVID-19 versus other causes: population-based cohort analysis of UK primary care data and linked national death registrations within the OpenSAFELY platform","volume":"6","author":"Bhaskaran","year":"2021","journal-title":"Lancet Reg Health Eur"},{"key":"2023040221104575700_","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1093\/aje\/kwac035","article-title":"Misconceptions about misclassification: non-differential misclassification does not always bias results toward the null","volume":"191","author":"Yland","year":"2022","journal-title":"Am J Epidemiol"},{"key":"2023040221104575700_","author":"Lovett","year":"2020"},{"key":"2023040221104575700_","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1002\/ajim.23145","article-title":"Differential occupational risk for COVID-19 and other infection exposure according to race and ethnicity","volume":"63","author":"Hawkins","year":"2020","journal-title":"Am J Ind Med"},{"key":"2023040221104575700_","author":"Gov.UK","year":"2022"},{"key":"2023040221104575700_","author":"Race Equality Foundation","year":"2022"},{"key":"2023040221104575700_","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.ssmph.2017.11.001","article-title":"Living with parents or grandparents increases social capital and survival: 2014 General Social Survey-National Death Index","volume":"4","author":"Muennig","year":"2018","journal-title":"SSM Popul Health"},{"key":"2023040221104575700_","doi-asserted-by":"crossref","first-page":"100466","DOI":"10.1016\/j.eclinm.2020.100466","article-title":"Socio-demographic heterogeneity in the prevalence of COVID-19 during lockdown is associated with ethnicity and household size: Results from an observational cohort study","volume":"25","author":"Martin","year":"2020","journal-title":"EClinicalMedicine"},{"key":"2023040221104575700_","doi-asserted-by":"crossref","first-page":"n608","DOI":"10.1136\/bmj.n608","article-title":"Adherence to the test, trace, and isolate system in the UK: results from 37 nationally representative surveys","volume":"372","author":"Smith","year":"2021","journal-title":"BMJ"},{"key":"2023040221104575700_","author":"GOV.UK","year":"2020"},{"key":"2023040221104575700_","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.annepidem.2020.05.003","article-title":"Assessing differential impacts of COVID-19 on black communities","volume":"47","author":"Millett","year":"2020","journal-title":"Ann Epidemiol"},{"key":"2023040221104575700_","doi-asserted-by":"crossref","first-page":"e043577","DOI":"10.1136\/bmjopen-2020-043577","article-title":"Early perceptions and behavioural responses during the COVID-19 pandemic: a cross-sectional survey of UK adults","volume":"11","author":"Atchison","year":"2021","journal-title":"BMJ Open"},{"key":"2023040221104575700_","author":"Office for National Statistics","year":"2020"},{"key":"2023040221104575700_","doi-asserted-by":"crossref","first-page":"m4921","DOI":"10.1136\/bmj.m4921","article-title":"Mitigating ethnic disparities in covid-19 and beyond","volume":"372","author":"Razai","year":"2021","journal-title":"BMJ"},{"key":"2023040221104575700_","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jad.2016.02.054","article-title":"Loneliness, common mental disorders and suicidal behavior: findings from a general population survey","volume":"197","author":"Stickley","year":"2016","journal-title":"J Affect Disord"},{"key":"2023040221104575700_","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.puhe.2017.07.035","article-title":"An overview of systematic reviews on the public health consequences of social isolation and loneliness","volume":"152","author":"Leigh-Hunt","year":"2017","journal-title":"Public Health"},{"key":"2023040221104575700_","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1001\/jamapsychiatry.2020.0027","article-title":"Battling the modern behavioral epidemic of loneliness: suggestions for research and interventions","volume":"77","author":"Jeste","year":"2020","journal-title":"JAMA Psychiatry"},{"key":"2023040221104575700_","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.puhe.2020.06.036","article-title":"Who is lonely in lockdown? Cross-cohort analyses of predictors of loneliness before and during the COVID-19 pandemic","volume":"186","author":"Bu","year":"2020","journal-title":"Public Health"}],"container-title":["International Journal of Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ije\/article-pdf\/51\/6\/1745\/49726827\/dyac158.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ije\/article-pdf\/51\/6\/1745\/49726827\/dyac158.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,25]],"date-time":"2023-11-25T14:25:50Z","timestamp":1700922350000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ije\/article\/51\/6\/1745\/6665821"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,13]]},"references-count":38,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2022,8,13]]},"published-print":{"date-parts":[[2022,12,13]]}},"URL":"https:\/\/doi.org\/10.1093\/ije\/dyac158","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2022.04.22.22274176","asserted-by":"object"}]},"ISSN":["0300-5771","1464-3685"],"issn-type":[{"value":"0300-5771","type":"print"},{"value":"1464-3685","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,12,1]]},"published":{"date-parts":[[2022,8,13]]}}}