{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:05:38Z","timestamp":1792785938776,"version":"4.5.0"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T00:00:00Z","timestamp":1663804800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"NHMRC","doi-asserted-by":"publisher","award":["1196900"],"award-info":[{"award-number":["1196900"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"NHMRC","doi-asserted-by":"publisher","award":["1028543"],"award-info":[{"award-number":["1028543"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"NHMRC","doi-asserted-by":"publisher","award":["2005259"],"award-info":[{"award-number":["2005259"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"NHMRC","doi-asserted-by":"publisher","award":["1158763"],"award-info":[{"award-number":["1158763"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"NHMRC","doi-asserted-by":"publisher","award":["2007048"],"award-info":[{"award-number":["2007048"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"name":"UNSW Scientia Award"},{"name":"NSW Health Early-Mid Career Fellowship"},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Canada Research Chair in Drug Policy Research & Evaluation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,2,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Conflicting evidence suggests a possible association between use of prescribed psychostimulants during pregnancy and adverse perinatal outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted population-based cohort studies including pregnancies conceived between April 2002 and March 2017 (Ontario, Canada; N\u2009=\u2009554\u200a272) and January 2003 to April 2011 [New South Wales (NSW), Australia; N\u2009=\u2009139\u200a229]. We evaluated the association between exposure to prescription amphetamine, methylphenidate, dextroamphetamine or lisdexamfetamine during pregnancy and pre-eclampsia, placental abruption, preterm birth, low birthweight, small for gestational age and neonatal intensive care unit admission. We used inverse probability of treatment weighting based on propensity scores to balance measured confounders between exposed and unexposed pregnancies. Additionally, we restricted the Ontario cohort to social security beneficiaries where supplementary confounder information was available.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In Ontario and NSW respectively, 1360 (0.25%) and 146 (0.10%) pregnancies were exposed to psychostimulants. Crude analyses indicated associations between exposure and nearly all outcomes [OR range 1.15\u20132.16 (Ontario); 0.97\u20132.20 (NSW)]. Nearly all associations were attenuated after weighting. Pre-eclampsia was the exception: odds remained elevated in the weighted analysis of the Ontario cohort (OR 2.02, 95% CI 1.42\u20132.88), although some attenuation occurred in NSW (weighted OR 1.50, 95% CI 0.77\u20132.94) and upon restriction to social security beneficiaries (weighted OR 1.24, 95% CI 0.64\u20132.40), and confidence intervals were wide.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We observed higher rates of outcomes among exposed pregnancies, but the attenuation of associations after adjustment and likelihood of residual confounding suggests psychostimulant exposure is not a major causal factor for most measured outcomes. Our findings for pre-eclampsia were inconclusive; exposed pregnancies may benefit from closer monitoring.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ije\/dyac180","type":"journal-article","created":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T00:47:57Z","timestamp":1663030077000},"page":"190-202","source":"Crossref","is-referenced-by-count":15,"title":["The association between psychostimulant use in pregnancy and adverse maternal and neonatal outcomes: results from a distributed analysis in two similar jurisdictions"],"prefix":"10.1093","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2371-1441","authenticated-orcid":false,"given":"Ximena","family":"Camacho","sequence":"first","affiliation":[{"name":"Centre for Big Data Research in Health, Faculty of Medicine and Health, UNSW Sydney , Sydney, NSW, Australia"},{"name":"NHMRC Centre of Research Excellence in Medicines Intelligence , Sydney, NSW, 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L","family":"Schaffer","sequence":"additional","affiliation":[{"name":"Centre for Big Data Research in Health, Faculty of Medicine and Health, UNSW Sydney , Sydney, NSW, Australia"},{"name":"NHMRC Centre of Research Excellence in Medicines Intelligence , Sydney, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Henry","sequence":"additional","affiliation":[{"name":"NHMRC Centre of Research Excellence in Medicines Intelligence , Sydney, NSW, Australia"},{"name":"ICES , Toronto, ON, Canada"},{"name":"Institute for Evidence Based Healthcare, Bond University , Robina, QLD, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sallie-Anne","family":"Pearson","sequence":"additional","affiliation":[{"name":"Centre for Big Data Research in Health, Faculty of Medicine and Health, UNSW Sydney , Sydney, NSW, Australia"},{"name":"NHMRC Centre of Research Excellence in Medicines Intelligence , Sydney, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2736-9639","authenticated-orcid":false,"given":"Simone","family":"Vigod","sequence":"additional","affiliation":[{"name":"ICES , Toronto, ON, Canada"},{"name":"Women\u2019s College Research Institute, Women\u2019s College Hospital , Toronto, ON, Canada"},{"name":"Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto , Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alys","family":"Havard","sequence":"additional","affiliation":[{"name":"Centre for Big Data Research in Health, Faculty of Medicine and Health, UNSW Sydney , Sydney, NSW, Australia"},{"name":"NHMRC Centre of Research Excellence in Medicines Intelligence , Sydney, NSW, Australia"},{"name":"National Drug and Alcohol Research Centre, UNSW Sydney , Sydney, NSW, 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