{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T02:45:26Z","timestamp":1769309126769,"version":"3.49.0"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T00:00:00Z","timestamp":1692748800000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008730","name":"Norwegian Cancer Society","doi-asserted-by":"publisher","award":["5703714\u20132014"],"award-info":[{"award-number":["5703714\u20132014"]}],"id":[{"id":"10.13039\/100008730","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Faculty of Medicine, University of Bergen"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Individuals with major birth defects are at increased risk of developing cancer, indicating a common aetiology. However, whether the siblings of individuals with birth defects are also at an increased risk of cancer is unclear.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We used nationwide health registries in four Nordic countries and conducted a nested case-control study. We included 40\u200a538 cancer cases (aged 0\u201346\u2009years) and 481\u200a945 population controls (matched by birth year and country), born between 1967 and 2014. The relative risk of cancer among individuals whose siblings had birth defects was computed with odds ratios (OR) and 95% confidence intervals (CIs), using logistic regression models.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In the total study population (aged 0\u201346\u2009years), we observed no overall difference in cancer risk between individuals whose siblings had birth defects and those who had unaffected siblings (OR 1.02; 95% CI 0.97\u20131.08); however, the risk of lymphoid and haematopoietic malignancies was elevated (1.16; 1.05\u20131.28). The overall risk of childhood cancer (0\u201319\u2009years) was increased for siblings of individuals who had birth defects (1.09; 1.00\u20131.19), which was mainly driven by lymphoma (1.35; 1.09\u20131.66), neuroblastoma (1.51; 1.11\u20132.05) and renal carcinoma (5.03; 1.73\u201314.6). The risk of cancer also increased with the number of siblings with birth defects (Ptrend = 0.008).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Overall risk of cancer among individuals (aged 0\u201346\u2009years) whose siblings had birth defects was not elevated, but the risk of childhood cancer (ages 0\u201319\u2009years) was increased. Our novel findings are consistent with the common aetiologies of birth defects and cancer, such as shared genetic predisposition and environmental factors.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ije\/dyad113","type":"journal-article","created":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T05:48:05Z","timestamp":1692769685000},"page":"1826-1835","source":"Crossref","is-referenced-by-count":3,"title":["Cancer risk in the siblings of individuals with major birth defects: a large Nordic population-based case-control study"],"prefix":"10.1093","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0903-1140","authenticated-orcid":false,"given":"Dagrun Sletteb\u00f8","family":"Daltveit","sequence":"first","affiliation":[{"name":"Department of Global Public Health and Primary Care, University of Bergen , Bergen, Norway"},{"name":"Norwegian Quality Registry of Cleft Lip and Palate, Surgical Clinic, Haukeland University Hospital , Bergen, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kari","family":"Klungs\u00f8yr","sequence":"additional","affiliation":[{"name":"Department of Global Public Health and Primary Care, University of Bergen , Bergen, Norway"},{"name":"Division of Mental and Physical Health, Norwegian Institute of Public Health , Bergen, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5620-9207","authenticated-orcid":false,"given":"Anders","family":"Engeland","sequence":"additional","affiliation":[{"name":"Department of Global Public Health and Primary Care, University of Bergen , Bergen, Norway"},{"name":"Division of Mental and Physical Health, Norwegian Institute of Public Health , Bergen, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"Ekbom","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Division, Department of Medicine Solna, Karolinska Institutet , Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8254-7525","authenticated-orcid":false,"given":"Mika","family":"Gissler","sequence":"additional","affiliation":[{"name":"Department of Knowledge Brokers, Finnish Institute for Health and Welfare (THL) , Helsinki, Finland"},{"name":"Region Stockholm, Academic Primary Health Care Centre , Stockholm, Sweden"},{"name":"Department of Molecular Medicine and Surgery, Karolinska Institutet , Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingrid","family":"Glimelius","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Division, Department of Medicine Solna, Karolinska Institutet , Stockholm, Sweden"},{"name":"Department of Immunology, Genetics and Pathology, Cancer Precision Medicine, Uppsala University , Uppsala, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom","family":"Grotmol","sequence":"additional","affiliation":[{"name":"Cancer Registry of Norway , Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Madanat-Harjuoja","sequence":"additional","affiliation":[{"name":"Cancer Society of Finland, Finnish Cancer Registry , Helsinki, Finland"},{"name":"Dana Farber Cancer Institute\/Boston Children\u2019s Cancer and Blood Disorders Centre , Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne Gulbech","family":"Ording","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology, Aarhus University Hospital and Aarhus University , Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik Toft","family":"S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology, Aarhus University Hospital and Aarhus 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