{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T18:23:32Z","timestamp":1791570212352,"version":"4.3.4"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,4,19]],"date-time":"2024-04-19T00:00:00Z","timestamp":1713484800000},"content-version":"vor","delay-in-days":8,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Sigrid Juselius Foundation, the Finnish Foundation for Cardiovascular Research and the Research Council of Finland","award":["357183"],"award-info":[{"award-number":["357183"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Accurate characterization of how age influences body weight and metabolism at different stages of life is important for understanding ageing processes. Here, we explore observational longitudinal associations between metabolic health and weight from the fifth to the seventh decade of life, using carefully adjusted statistical designs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Body measures and biochemical data from blood and urine (220 measures) across two visits were available from 10\u200a104 UK Biobank participants. Participants were divided into stable (within \u00b14% per decade), weight loss and weight gain categories. Final subgroups were metabolically matched at baseline (48% women, follow-up 4.3\u2009years, ages 41\u201370; n\u2009=\u20093368 per subgroup) and further stratified by the median age of 59.3\u2009years and sex.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Pulse pressure, haemoglobin A1c and cystatin-C tracked ageing consistently (P\u2009&amp;lt;\u20090.0001). In women under 59, age-associated increases in citrate, pyruvate, alkaline phosphatase and calcium were observed along with adverse changes across lipoprotein measures, fatty acid species and liver enzymes (P\u2009&amp;lt;\u20090.0001). Principal component analysis revealed a qualitative sex difference in the temporal relationship between body weight and metabolism: weight loss was not associated with systemic metabolic improvement in women, whereas both age strata converged consistently towards beneficial (weight loss) or adverse (weight gain) phenotypes in men.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We report longitudinal ageing trends for 220 metabolic measures in absolute concentrations, many of which have not been described for older individuals before. Our results also revealed a fundamental dynamic sex divergence that we speculate is caused by menopause-driven metabolic deterioration in women.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ije\/dyae055","type":"journal-article","created":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T10:26:23Z","timestamp":1712226383000},"source":"Crossref","is-referenced-by-count":22,"title":["Influence of age and sex on longitudinal metabolic profiles and body weight trajectories in the UK Biobank"],"prefix":"10.1093","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7262-2656","authenticated-orcid":false,"given":"Ville-Petteri","family":"M\u00e4kinen","sequence":"first","affiliation":[{"name":"Systems Epidemiology, Research Unit of Population Health, Faculty of Medicine, University of Oulu , Oulu, Finland"},{"name":"Biocenter Oulu, University of Oulu , Oulu, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5905-1206","authenticated-orcid":false,"given":"Mika","family":"Ala-Korpela","sequence":"additional","affiliation":[{"name":"Systems Epidemiology, Research Unit of Population Health, Faculty of Medicine, University of Oulu , Oulu, Finland"},{"name":"Biocenter Oulu, University of Oulu , Oulu, Finland"},{"name":"NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland , Kuopio, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,4,19]]},"reference":[{"key":"2024042002275954700_dyae055-B1","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/S0140-6736(17)32152-9","article-title":"Global, regional, and national age-sex specific mortality for 264 causes of death, 1980\u20132016: a systematic analysis for the Global Burden of Disease Study 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