{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T13:51:23Z","timestamp":1785419483357,"version":"3.56.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,4,12]],"date-time":"2025-04-12T00:00:00Z","timestamp":1744416000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Early alcohol use is hazardous to health and restrictions to age at first drink (AFD) is a cornerstone of public health policy in many nations. We explored the long-term impact of AFD on mortality after early adulthood in community-dwelling Koreans.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A cohort of 36\u2009159 adults aged 35\u201364\u2009years from the Korean National Health and Nutrition Examination Survey, linked to cause-of-death statistics, was followed up for a median of 9.9\u2009years. Based on AFD with a cutoff at South Korea\u2019s legal drinking age, the participants were divided into three groups: AFD\u2009&amp;lt;\u200919, AFD\u2009\u2265\u200919, and lifetime abstainer. The outcome variable was all-cause mortality.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 9723 (26.9%) participants reported AFD\u2009&amp;lt;\u200919. During the follow-up, 1073 (3.0%) participants died. AFD\u2009&amp;lt;\u200919 was associated with an increased risk of mortality than lifetime abstainers (adjusted hazards ratio [aHR] 1.29, 95% confidence interval [CI] 1.02\u20131.64). Female drinkers with AFD\u2009&amp;lt;\u200919 showed an increased risk of mortality than female lifetime abstainers (aHR 2.02, CI 1.26\u20133.25). Current drinkers with AFD\u2009&amp;lt;\u200919 was associated with a greater risk of mortality than those with AFD\u2009\u2265\u200919 (aHR 1.20, 95%CI 1.01\u20131.42). Among participants with hazardous drinking habits, AFD\u2009&amp;lt;\u200919 was associated with a greater risk of mortality than AFD\u2009\u2265\u200919 (aHR 1.32, 95%CI 1.07\u20131.64).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Individuals with AFD\u2009&amp;lt;\u200919 were at greater risk of mortality than lifetime abstainers; earlier AFD was associated with a greater mortality risk than later AFD. Prevention and early intervention programs can improve the long-term health of alcohol-consuming population.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ije\/dyaf061","type":"journal-article","created":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T04:54:55Z","timestamp":1747976095000},"source":"Crossref","is-referenced-by-count":2,"title":["Age at first drink as a predictor of all-cause mortality of middle-aged Koreans"],"prefix":"10.1093","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3616-0810","authenticated-orcid":false,"given":"Horim A","family":"Hwang","sequence":"first","affiliation":[{"name":"Department of Preventive Medicine, College of Medicine, The Catholic University of Korea , Seoul, South","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8015-9948","authenticated-orcid":false,"given":"Dong Jun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, College of Medicine, The Catholic University of Korea , Seoul, South","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0519-1278","authenticated-orcid":false,"given":"Seongju","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, College of Medicine, The Catholic University of Korea , Seoul, South","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8426-2045","authenticated-orcid":false,"given":"Hooyeon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, College of Medicine, The Catholic University of Korea , Seoul, 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