{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T15:14:20Z","timestamp":1780758860071,"version":"3.54.1"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T00:00:00Z","timestamp":1749427200000},"content-version":"vor","delay-in-days":58,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004411","name":"Heart and Stroke Foundation of Canada","doi-asserted-by":"publisher","award":["G-22\u20130031974"],"award-info":[{"award-number":["G-22\u20130031974"]}],"id":[{"id":"10.13039\/100004411","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fonds de recherche du Qu\u00e9bec-Sant\u00e9","award":["296785"],"award-info":[{"award-number":["296785"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Pre-eclampsia is associated with acute hepatic complications, but the risk of developing chronic liver disease is unclear. We determined whether pre-eclampsia was associated with chronic liver disease for up to three decades after pregnancy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We conducted a longitudinal population-based cohort study of 1 460 099 pregnant women with and without pre-eclampsia in Quebec, Canada, between 1989 and 2022. The main exposure was pre-eclampsia in any pregnancy. Outcomes included hospitalization for liver disease during 26\u00a0275\u00a0081 person-years of follow-up after pregnancy. Using Cox regression models adjusted for age, comorbidity, and socio-economic disadvantage, we estimated hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between pre-eclampsia and liver disease.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Women with pre-eclampsia had a higher incidence of hospitalization for liver disease than women without pre-eclampsia (119.3 vs. 61.5 per 100 000 person-years). During a median follow-up of 18.4\u2009years, pre-eclampsia was associated with 1.85 times the risk of hospitalization for liver disease (95% CI 1.75\u20131.95). Early-onset pre-eclampsia (HR 2.36, 95% CI 2.04\u20132.74), superimposed pre-eclampsia (HR 2.78, 95% CI 2.30\u20133.36), and pre-eclampsia recurring in more than one pregnancy (HR 3.00, 95% CI 2.59\u20133.46) were strongly associated with liver hospitalization. Associations were present with several liver complications, including hepatic cirrhosis, chronic hepatitis, fatty liver disease, and hepatic failure. Pre-eclampsia was more strongly associated with hepatic hospitalization within 5\u00a0years of pregnancy, although risks persisted for up to 33\u2009years later.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Pre-eclampsia is associated with the long-term risk of liver disease up to 33\u2009years after pregnancy.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ije\/dyaf072","type":"journal-article","created":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T20:59:52Z","timestamp":1749502792000},"source":"Crossref","is-referenced-by-count":5,"title":["Long-term risk of chronic liver disease after pre-eclampsia"],"prefix":"10.1093","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2412-0459","authenticated-orcid":false,"given":"Nathalie","family":"Auger","sequence":"first","affiliation":[{"name":"Health Innovation and Evaluation Hub, University of Montreal Hospital Research Centre , Montreal, QC,","place":["Canada"]},{"name":"Bureau d'information et d'\u00e9tudes en sant\u00e9 des populations, Institut national de sant\u00e9 publique du Qu\u00e9bec , Montreal, QC,","place":["Canada"]},{"name":"Department of Social and Preventive Medicine, School of Public Health, University of Montreal , Montreal, QC,","place":["Canada"]},{"name":"Department of Epidemiology, Biostatistics and Occupational Health, McGill University , Montreal, QC,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabrielle","family":"Jutras","sequence":"additional","affiliation":[{"name":"Health Innovation and Evaluation Hub, University of Montreal Hospital Research Centre , Montreal, QC,","place":["Canada"]},{"name":"Division of Gastroenterology, Department of Medicine, University of Montreal , Montreal, QC,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Paradis","sequence":"additional","affiliation":[{"name":"Bureau d'information et d'\u00e9tudes en sant\u00e9 des populations, Institut national de sant\u00e9 publique du Qu\u00e9bec , Montreal, QC,","place":["Canada"]},{"name":"Department of Epidemiology, Biostatistics and Occupational Health, McGill University , Montreal, QC,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aimina","family":"Ayoub","sequence":"additional","affiliation":[{"name":"Health Innovation and Evaluation Hub, University of Montreal Hospital Research Centre , Montreal, QC,","place":["Canada"]},{"name":"Bureau d'information et d'\u00e9tudes en sant\u00e9 des populations, Institut national de sant\u00e9 publique du Qu\u00e9bec , Montreal, QC,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Lewin","sequence":"additional","affiliation":[{"name":"Medical Affairs and Innovation, Hema-Quebec , Montreal, QC,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Maniraho","sequence":"additional","affiliation":[{"name":"Health Innovation and Evaluation Hub, University of Montreal Hospital Research Centre , Montreal, QC,","place":["Canada"]},{"name":"Bureau d'information et d'\u00e9tudes en sant\u00e9 des populations, Institut national de sant\u00e9 publique du Qu\u00e9bec , Montreal, QC,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian J","family":"Potter","sequence":"additional","affiliation":[{"name":"Health Innovation and Evaluation Hub, University of Montreal Hospital Research Centre , Montreal, QC,","place":["Canada"]},{"name":"Division of Cardiology, Department of Medicine, University of Montreal Hospital Centre , Montreal, QC,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,6,9]]},"reference":[{"key":"2025060916594617000_dyaf072-B1","doi-asserted-by":"crossref","first-page":"313","DOI":"10.14740\/gr693w","article-title":"Postpartum acute liver dysfunction: a case of acute fatty liver of pregnancy developing massive intrahepatic calcification","volume":"8","author":"Bhat","year":"2015","journal-title":"Gastroenterol 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