{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T08:00:48Z","timestamp":1767772848781,"version":"build-2065373602"},"reference-count":67,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T00:00:00Z","timestamp":1760400000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"French National Cancer Institute (INCa","award":["2013\u2013143"],"award-info":[{"award-number":["2013\u2013143"]}]},{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","award":["N\u00b0ENV201306\/CLB"],"award-info":[{"award-number":["N\u00b0ENV201306\/CLB"]}],"id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004431","name":"Fondation de France","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004431","id-type":"DOI","asserted-by":"publisher"}]},{"name":"University Lyon 1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Despite an incidence increase in recent decades, the etiology of testicular germ cell tumors (TGCT) remains poorly understood. The hypothesis of a two-stage development, combining initial alteration in utero followed by malignant transformation later in life, has been suggested. This study examined the association between cumulative lifetime occupational and para-occupational solvent exposure and TGCT risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The French multicenter case\u2013control study TESTIS included 454 cases and 670 controls. Participants provided information on their occupational history; participants\u2019 mothers (N\u2009=\u2009547) provided information on their own and the father\u2019s occupational history. Solvent exposure was assessed by using the Matg\u00e9n\u00e9 job\u2013exposure matrices. The influence of the parental and subject\u2019s occupational exposures over the lifetime and at different periods (i.e. fetal life\/infancy; childhood; adolescence; subject\u2019s exposure) on TGCT was examined. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated by using conditional logistic regression models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>An OR for TGCT of 1.03 (95% CI 0.59\u20131.79) was found for the lifetime solvent exposure. When each period was examined individually, the results showed an increased TGCT risk in adult males who were occupationally exposed to trichloroethylene (OR\u2009=\u20093.09; 95% CI 1.25\u20137.65); fuels and petroleum-based solvents (OR\u2009=\u20091.91; 95% CI 1.21\u20133.02); diesel, kerosene, and fuel oil (OR\u2009=\u20092.26; 95% CI 1.16\u20134.41); and ketones and esters (OR\u2009=\u20091.66; 95% CI 1.02\u20132.71), and suggested a positive association with solvent exposure during adolescence (OR\u2009=\u20091.77; 95% CI 0.95\u20133.31).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Overall, this study did not suggest a substantial role of cumulative lifetime solvent exposure and TGCT risk. The results showed an increased TGCT risk associated with solvent exposure during adulthood. Indirect exposure to certain solvents during adolescence might also promote TGCT development.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ije\/dyaf175","type":"journal-article","created":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T08:50:41Z","timestamp":1762678241000},"source":"Crossref","is-referenced-by-count":1,"title":["Lifetime occupational and para-occupational exposure to organic solvents and testicular germ cell tumor risk: a French case\u2013control study\u2014TESTIS"],"prefix":"10.1093","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9091-6703","authenticated-orcid":false,"given":"Margot","family":"Guth","sequence":"first","affiliation":[{"name":"UMRESTTE, UMR T 9405, IFSTTAR, Lyon 1 University, Lyon University, Eiffel University , Lyon,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"Lefevre","sequence":"additional","affiliation":[{"name":"UMRESTTE, UMR T 9405, IFSTTAR, Lyon 1 University, Lyon University, Eiffel University , Lyon,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2726-1000","authenticated-orcid":false,"given":"Astrid","family":"Coste","sequence":"additional","affiliation":[{"name":"INSERM UMR1296 Radiation: Defense, Health, Environment , Lyon,","place":["France"]},{"name":"Prevention Cancer Environnement Departement, Centre L\u00e9on B\u00e9rard , Lyon,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Delphine","family":"Praud","sequence":"additional","affiliation":[{"name":"INSERM UMR1296 Radiation: Defense, Health, Environment , Lyon,","place":["France"]},{"name":"Prevention Cancer Environnement Departement, Centre L\u00e9on B\u00e9rard , Lyon,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivia","family":"Perol","sequence":"additional","affiliation":[{"name":"Prevention Cancer Environnement Departement, Centre L\u00e9on B\u00e9rard , Lyon,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corinne","family":"Pilorget","sequence":"additional","affiliation":[{"name":"Sant\u00e9 Publique France\u2014French National Public Health Agency , Saint-Maurice,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brigitte","family":"Dananch\u00e9","sequence":"additional","affiliation":[{"name":"Prevention Cancer Environnement Departement, Centre L\u00e9on B\u00e9rard , Lyon,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aur\u00e9lie","family":"Danjou","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9 and Universit\u00e9 Sorbonne Paris Nord, Inserm, INRAE, Center for Research in Epidemiology and StatisticS (CRESS), Epidemiology of Childhood and Adolescent Cancer (EPICEA) Team , Paris,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeanne","family":"Perrin","sequence":"additional","affiliation":[{"name":"Laboratory of Reproductive Biology-CECOS, Clinical-Biological Centre of Assisted Reproductive Medicine, Hopitaux Universitaires de Marseille , Marseille,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V\u00e9ronique","family":"Drouineaud","sequence":"additional","affiliation":[{"name":"CECOS Paris Cochin, H\u00f4pital Cochin , Paris,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1540-0536","authenticated-orcid":false,"given":"Louis","family":"Bujan","sequence":"additional","affiliation":[{"name":"DEFE (D\u00e9veloppement Embryonnaire, Fertilit\u00e9, Environnement) INSERM 1202 Universit\u00e9s Montpellier et Toulouse 3, CECOS H\u00f4pital Paule de Viguier, CHU de Toulouse , Toulouse,","place":["France"]},{"name":"F\u00e9d\u00e9ration Fran\u00e7aise des CECOS , Paris,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joachim","family":"Sch\u00fcz","sequence":"additional","affiliation":[{"name":"Environment and Lifestyle Epidemiology Branch, International Agency for Research on Cancer\/World Health Organization (IARC\/WHO) , Lyon, Cedex 08,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann","family":"Olsson","sequence":"additional","affiliation":[{"name":"Environment and Lifestyle Epidemiology Branch, International Agency for Research on Cancer\/World Health Organization (IARC\/WHO) , Lyon, Cedex 08,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Charbotel","sequence":"additional","affiliation":[{"name":"UMRESTTE, UMR T 9405, IFSTTAR, Lyon 1 University, Lyon University, Eiffel University , Lyon,","place":["France"]},{"name":"CRPPE-Lyon , Hospices Civils de Lyon, Lyon,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3498-6499","authenticated-orcid":false,"given":"B\u00e9atrice","family":"Fervers","sequence":"additional","affiliation":[{"name":"INSERM UMR1296 Radiation: Defense, Health, Environment , Lyon,","place":["France"]},{"name":"Prevention Cancer Environnement Departement, Centre L\u00e9on B\u00e9rard , Lyon,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"The TESTIS Study Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Boyle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aude","family":"Fl\u00e9chon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elodie","family":"Belladame","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R\u00e9mi","family":"B\u00e9ranger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9line","family":"Chalas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myriam","family":"Virlouvet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucile","family":"Ferreux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillemette","family":"Perier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pauline","family":"Peretout","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diane","family":"Rivet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandrine","family":"Rulle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florence","family":"Eustache","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"Sermondade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marine","family":"Durand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Levy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle","family":"Berthaut","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline","family":"Saias-Magnan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Metzler-Guillemain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carole","family":"Daoud-Deveze","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myriam","family":"Daudin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florence","family":"Brugnon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val\u00e9rie","family":"Bruhat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cyril","family":"Bouche","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle","family":"Kocsinski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marius","family":"Teletin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7oise","family":"Schmitt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"Guyomard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aline","family":"Papaxanthos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Volcy","family":"Soula","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandrine Giscard","family":"d'Estaing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascale","family":"Dehee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Delphine","family":"Yalcinkaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9line","family":"Bouillon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cynthia","family":"Frapsauce","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Viallon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00e9reng\u00e8re","family":"Ducrocq","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-Ange","family":"Clarotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ethel","family":"Szerman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Am\u00e9lie","family":"Ancelle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oxana Blagosklonovand S\u00e9verine","family":"Bey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9lia","family":"Ravel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00e9gol\u00e8ne","family":"Veau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agn\u00e8s","family":"Letremy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Fauque","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Barberet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"St\u00e9phanie","family":"Lattes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuelle","family":"Thibault","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Diligent","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christel","family":"Hersant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa","family":"Loup-Cabaniols","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Gala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvianne","family":"Hennebicq","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julien","family":"Bessonnat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-Claude","family":"Blocquaux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,11,7]]},"reference":[{"key":"2025110903503981500_dyaf175-B1","first-page":"209","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J Clin"},{"key":"2025110903503981500_dyaf175-B2","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1002\/ijc.32810","article-title":"Testicular cancer incidence predictions in Europe 2010-2035: a rising burden despite population ageing","volume":"147","author":"Znaor","year":"2020","journal-title":"Int J Cancer"},{"key":"2025110903503981500_dyaf175-B3","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1365-2605.1987.tb00161.x","article-title":"Carcinoma-in-situ of the testis: possible origin from gonocytes and precursor of all types of germ cell tumours except spermatocytoma","volume":"10","author":"Skakkebaek","year":"1987","journal-title":"Int J Androl"},{"key":"2025110903503981500_dyaf175-B4","doi-asserted-by":"crossref","first-page":"724","DOI":"10.3390\/medicina59040724","article-title":"Risk factors for testicular cancer: environment, genes and infections\u2014is it all?","volume":"59","author":"Yazici","year":"2023","journal-title":"Medicina (Mex)"},{"key":"2025110903503981500_dyaf175-B5","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1016\/S0140-6736(15)00991-5","article-title":"Testicular germ cell tumours","volume":"387","author":"Rajpert-De Meyts","year":"2016","journal-title":"Lancet"},{"key":"2025110903503981500_dyaf175-B6","doi-asserted-by":"crossref","first-page":"e77130","DOI":"10.1371\/journal.pone.0077130","article-title":"Occupational and environmental exposures associated with testicular germ cell tumours: systematic review of prenatal and life-long exposures","volume":"8","author":"B\u00e9ranger","year":"2013","journal-title":"PLoS One"},{"key":"2025110903503981500_dyaf175-B7","doi-asserted-by":"crossref","first-page":"359","DOI":"10.5271\/sjweh.4161","article-title":"Occupational exposure to organic solvents and the risk of developing testicular germ cell tumors (TESTIS study): Effect of combined exposure assessment on risk estimation","volume":"50","author":"Guth","year":"2024","journal-title":"Scand J Work Environ Health"},{"key":"2025110903503981500_dyaf175-B8","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1007\/BF03345069","article-title":"Occupational and environmental agents as endocrine disruptors: experimental and human evidence","volume":"23","author":"Baccarelli","year":"2000","journal-title":"J Endocrinol Invest"},{"key":"2025110903503981500_dyaf175-B9","volume-title":". List of Classifications","author":"IARC Monographs on the Identification of Carcinogenic Hazards to Humans","year":"2022"},{"key":"2025110903503981500_dyaf175-B10","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1080\/1071576021000033103","article-title":"Oxidative DNA damage induced by toluene is involved in its male reproductive toxicity","volume":"37","author":"Nakai","year":"2003","journal-title":"Free Radic Res"},{"key":"2025110903503981500_dyaf175-B11","first-page":"1","article-title":"Trichloroethylene, Tetrachloroethylene, and some other chlorinated agents","volume":"106","author":"IARC Working Group on the Evaluation of Carcinogenic Risks to Humans","year":"2014","journal-title":"Iarc Monogr Eval Carcinog Risks Hum"},{"key":"2025110903503981500_dyaf175-B12","doi-asserted-by":"crossref","first-page":"067023","DOI":"10.1289\/EHP864","article-title":"Parental occupational exposure to organic solvents and testicular germ cell tumors in their offspring: NORD-TEST study","volume":"125","author":"Le Cornet","year":"2017","journal-title":"Environ Health Perspect"},{"key":"2025110903503981500_dyaf175-B13","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/andr.306","article-title":"A survey of etiologic hypotheses among testicular cancer researchers","volume":"3","author":"Stang","year":"2015","journal-title":"Andrology"},{"key":"2025110903503981500_dyaf175-B14","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1002\/ijc.30884","article-title":"Postnatal risk factors for testicular cancer: the EPSAM case-control study","volume":"141","author":"Moirano","year":"2017","journal-title":"Int J Cancer"},{"key":"2025110903503981500_dyaf175-B15","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/nrurol.2012.61","article-title":"Adolescent and adult risk factors for testicular cancer","volume":"9","author":"McGlynn","year":"2012","journal-title":"Nat Rev Urol"},{"key":"2025110903503981500_dyaf175-B16","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1093\/annweh\/wxaa006","article-title":"Eliminating take-home exposures: recognizing the role of occupational health and safety in broader community health","volume":"64","author":"Kalweit","year":"2020","journal-title":"Ann Work Expo Health"},{"key":"2025110903503981500_dyaf175-B17","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1002\/bdra.23520","article-title":"Birth defects in infants born to employees of a microelectronics and business machine manufacturing facility","volume":"106","author":"Silver","year":"2016","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"2025110903503981500_dyaf175-B18","doi-asserted-by":"crossref","first-page":"405","DOI":"10.5271\/sjweh.4102","article-title":"Parental occupational exposure to solvents and risk of developing testicular germ cell tumors among sons: a French nationwide case-control study (TESTIS study)","volume":"49","author":"Guth","year":"2023","journal-title":"Scand J Work Environ Health"},{"key":"2025110903503981500_dyaf175-B19","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/s12940-021-00795-y","article-title":"Domestic use of pesticides during early periods of development and risk of testicular germ cell tumors in adulthood: a French nationwide case-control study","volume":"20","author":"Danjou","year":"2021","journal-title":"Environ Health"},{"key":"2025110903503981500_dyaf175-B20","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1136\/oemed-2022-108601","article-title":"Testicular germ cell tumour risk by occupation and industry: a French case\u2013control study\u2014TESTIS","volume":"80","author":"Guth","year":"2023","journal-title":"Occup Environ Med"},{"key":"2025110903503981500_dyaf175-B21","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1186\/1471-2407-14-563","article-title":"Studying the impact of early life exposures to pesticides on the risk of testicular germ cell tumors during adulthood (TESTIS project): study protocol","volume":"14","author":"B\u00e9ranger","year":"2014","journal-title":"BMC Cancer"},{"key":"2025110903503981500_dyaf175-B22","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.eururo.2016.02.029","article-title":"The 2016 WHO Classification of tumours of the urinary system and male genital organs-part a: renal, penile, and testicular tumours","volume":"70","author":"Moch","year":"2016","journal-title":"Eur Urol"},{"key":"2025110903503981500_dyaf175-B23","volume-title":"International Classification of Diseases for Oncology: ICDO","author":"Fritz","year":"2013","edition":"3rd"},{"key":"2025110903503981500_dyaf175-B24","volume-title":"International Standard Classification of Occupations","author":"International Labour Office","year":"1969","edition":"Rev."},{"key":"2025110903503981500_dyaf175-B25","author":"INSEE","year":"2000"},{"key":"2025110903503981500_dyaf175-B26","first-page":"865","article-title":"Matg\u00e9n\u00e9: a program to develop job-exposure matrices in the general population in France","volume":"55","author":"F\u00e9votte","year":"2011","journal-title":"Ann Occup Hyg"},{"key":"2025110903503981500_dyaf175-B27","doi-asserted-by":"crossref","first-page":"e000262","DOI":"10.1136\/fmch-2019-000262","article-title":"Variable selection strategies and its importance in clinical prediction modelling","volume":"8","author":"Chowdhury","year":"2020","journal-title":"Fam Med Community Health"},{"key":"2025110903503981500_dyaf175-B28","doi-asserted-by":"crossref","first-page":"i969","DOI":"10.1136\/bmj.i969","article-title":"Analysis of matched case-control studies","volume":"352","author":"Pearce","year":"2016","journal-title":"BMJ"},{"key":"2025110903503981500_dyaf175-B29","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1002\/sim.9637","article-title":"A tree-based modeling approach for matched case-control studies","volume":"42","author":"Schauberger","year":"2023","journal-title":"Stat Med"},{"key":"2025110903503981500_dyaf175-B30","author":"Institut National de Recherche et de S\u00e9curit\u00e9 (INRS)","year":"2009"},{"key":"2025110903503981500_dyaf175-B31","author":"Bonventre","year":"2014"},{"key":"2025110903503981500_dyaf175-B32","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1007\/s40618-022-01769-8","article-title":"Risk factors on testicular function in adolescents","volume":"45","author":"Cargnelutti","year":"2022","journal-title":"J Endocrinol Invest"},{"key":"2025110903503981500_dyaf175-B33","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3200\/AEOH.61.2.87-95","article-title":"Endocrine-disrupting chemicals and testicular cancer: a case-control study","volume":"61","author":"Nori","year":"2006","journal-title":"Arch Environ Occup Health"},{"key":"2025110903503981500_dyaf175-B34","author":"IARC Working Group on the Evaluation of Carcinogenic Risks to Humans","year":"2014"},{"key":"2025110903503981500_dyaf175-B35","author":"Agency for Toxic Substances and Disease Registry-ATSDR","year":"2019"},{"key":"2025110903503981500_dyaf175-B36","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1006\/taap.2002.9421","article-title":"Metabolism and toxicity of trichloroethylene in epididymis and testis","volume":"182","author":"Forkert","year":"2002","journal-title":"Toxicol Appl Pharmacol"},{"key":"2025110903503981500_dyaf175-B37","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.reprotox.2006.07.001","article-title":"Toxicological review of male reproductive effects and trichloroethylene exposure: assessing the relevance to human male reproductive health","volume":"22","author":"Lamb","year":"2006","journal-title":"Reprod Toxicol"},{"key":"2025110903503981500_dyaf175-B38","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1093\/toxsci\/kfh277","article-title":"Exposure to trichloroethylene and its metabolites causes impairment of sperm fertilizing ability in mice","volume":"82","author":"Xu","year":"2004","journal-title":"Toxicol Sci"},{"key":"2025110903503981500_dyaf175-B39","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1191\/096032701718620882","article-title":"Trichloroethylene induced testicular toxicity in rats exposed by inhalation","volume":"20","author":"Kumar","year":"2001","journal-title":"Hum Exp Toxicol"},{"key":"2025110903503981500_dyaf175-B40","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1095\/biolreprod.103.022210","article-title":"Male reproductive toxicity of trichloroethylene: sperm protein oxidation and decreased fertilizing ability","volume":"70","author":"DuTeaux","year":"2004","journal-title":"Biol Reprod"},{"key":"2025110903503981500_dyaf175-B41","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1097\/00000542-198101000-00010","article-title":"Morphologic changes in mouse spermatozoa after exposure to inhalational anesthetics during early spermatogenesis","volume":"54","author":"Land","year":"1981","journal-title":"Anesthesiology. janv"},{"key":"2025110903503981500_dyaf175-B42","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1007\/978-3-642-69928-3_94","volume-title":"Receptors and Other Targets for Toxic Substances","author":"Cameron","year":"1985"},{"key":"2025110903503981500_dyaf175-B43","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1002\/art.10365","article-title":"Hormonal and reproductive risk factors for development of systemic lupus erythematosus: results of a population-based, case\u2013control study","volume":"46","author":"Cooper","year":"2002","journal-title":"Arthritis Rheum"},{"key":"2025110903503981500_dyaf175-B44","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1177\/074823379100700403","article-title":"Effects of methanol vapors on testosterone production and testis morphology in rats","volume":"7","author":"Lee","year":"1991","journal-title":"Toxicol Ind Health"},{"key":"2025110903503981500_dyaf175-B45","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1093\/humrep\/16.5.972","article-title":"Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspects","volume":"16","author":"Skakkebaek","year":"2001","journal-title":"Hum Reprod"},{"key":"2025110903503981500_dyaf175-B46","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1530\/rep.0.1250769","article-title":"Proliferation and functional maturation of Sertoli cells, and their relevance to disorders of testis function in adulthood","volume":"125","author":"Sharpe","year":"2003","journal-title":"Reproduction"},{"key":"2025110903503981500_dyaf175-B47","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1159\/000474570","article-title":"The possible role of sex hormones in the development of testicular cancer","volume":"23","author":"Rajpert-De Meyts","year":"1993","journal-title":"Eur Urol"},{"key":"2025110903503981500_dyaf175-B48","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.neo.2021.05.008","article-title":"On the origin of germ cell neoplasia in situ: Dedifferentiation of human adult Sertoli cells in cross talk with seminoma cells in vitro","volume":"23","author":"Fink","year":"2021","journal-title":"Neoplasia"},{"key":"2025110903503981500_dyaf175-B49","doi-asserted-by":"crossref","first-page":"e25978","DOI":"10.1371\/journal.pone.0025978","article-title":"Age-specific incidence data indicate four mutations are required for human testicular cancers","volume":"6","author":"Brody","year":"2011","journal-title":"PLoS One"},{"key":"2025110903503981500_dyaf175-B50","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1002\/ajim.22288","article-title":"Retrospective cohort study of a microelectronics and business machine facility","volume":"57","author":"Silver","year":"2014","journal-title":"Am J Ind Med"},{"key":"2025110903503981500_dyaf175-B51","first-page":"97","article-title":"Testicular cancer, occupation and exposure to chemical agents among Finnish men in 1971\u20131995","volume":"16","author":"Guo","year":"2005","journal-title":"Cancer Causes Control"},{"key":"2025110903503981500_dyaf175-B52","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1080\/15459624.2013.862591","article-title":"Retrospective assessment of exposure to chemicals for a microelectronics and business machine manufacturing facility","volume":"11","author":"Fleming","year":"2014","journal-title":"J Occup Environ Hyg"},{"key":"2025110903503981500_dyaf175-B53","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1080\/13510002.2015.1107312","article-title":"Redox status of the testes and sperm of rats following exposure to 2,5-hexanedione","volume":"21","author":"Adedara","year":"2016","journal-title":"Redox Rep"},{"key":"2025110903503981500_dyaf175-B54","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1146\/annurev.pharmtox.43.100901.135930","article-title":"2,5-Hexanedione-induced testicular injury","volume":"43","author":"Boekelheide","year":"2003","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"2025110903503981500_dyaf175-B55","doi-asserted-by":"crossref","first-page":"94","DOI":"10.3390\/jox11030007","article-title":"The central role of cytochrome P450 in xenobiotic metabolism\u2014a brief review on a fascinating enzyme family","volume":"11","author":"Esteves","year":"2021","journal-title":"J Xenobiot"},{"key":"2025110903503981500_dyaf175-B56","doi-asserted-by":"crossref","first-page":"15","DOI":"10.4161\/oxim.1.1.6843","article-title":"Antioxidant systems and oxidative stress in the testes","volume":"1","author":"Aitken","year":"2008","journal-title":"Oxid Med Cell Longev"},{"key":"2025110903503981500_dyaf175-B57","doi-asserted-by":"crossref","first-page":"10043","DOI":"10.3390\/ijms221810043","article-title":"Oxidative stress, testicular inflammatory pathways, and male reproduction","volume":"22","author":"Dutta","year":"2021","journal-title":"Int J Mol Sci"},{"key":"2025110903503981500_dyaf175-B58","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1136\/oem.56.9.581","article-title":"Mortality among aircraft manufacturing workers","volume":"56","author":"Boice","year":"1999","journal-title":"Occup Environ Med"},{"key":"2025110903503981500_dyaf175-B59","doi-asserted-by":"crossref","first-page":"273","DOI":"10.3109\/10408444.2015.1016216","article-title":"Characterization of the toxicological hazards of hydrocarbon solvents","volume":"45","author":"Mckee","year":"2015","journal-title":"Crit Rev Toxicol"},{"key":"2025110903503981500_dyaf175-B60","doi-asserted-by":"crossref","first-page":"206","DOI":"10.2486\/indhealth.39.206","article-title":"Effect of benzene, toluene, xylene on the semen quality and the function of accessory gonad of exposed workers","volume":"39","author":"Xiao","year":"2001","journal-title":"Ind Health"},{"key":"2025110903503981500_dyaf175-B61","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0015-0282(99)00515-4","article-title":"Semen quality of workers occupationally exposed to hydrocarbons","volume":"73","author":"De Celis","year":"2000","journal-title":"Fertil Steril"},{"key":"2025110903503981500_dyaf175-B62","first-page":"1","article-title":"NTP technical report on the toxicology and carcinogenesis studies of Stoddard Solvent IIC (Cas No. 64742-88-7) in F344\/N rats and B6C3F1 mice (inhalation studies)","volume":"519","author":"National Toxicology Program","year":"2004","journal-title":"Natl Toxicol Program Tech Rep Ser"},{"key":"2025110903503981500_dyaf175-B63","author":"Agency for Toxic Substances and Disease Registry-ATSDR","year":"2017"},{"key":"2025110903503981500_dyaf175-B64","author":"Sauv\u00e9","year":"2018"},{"key":"2025110903503981500_dyaf175-B65","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/ajim.20281","article-title":"Methodological issues regarding confounding and exposure misclassification in epidemiological studies of occupational exposures","volume":"50","author":"Blair","year":"2007","journal-title":"Am J Ind Med"},{"key":"2025110903503981500_dyaf175-B66","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1684\/bdc.2014.1901","article-title":"Testicular germ cell tumours and early exposures to pesticides: The TESTEPERA pilot study","volume":"101","author":"B\u00e9ranger","year":"2014","journal-title":"Bull Cancer"},{"key":"2025110903503981500_dyaf175-B67","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1093\/jnci\/djn441","article-title":"Mobile phone use and risk of uveal melanoma: results of the risk factors for Uveal Melanoma case-control study","volume":"101","author":"Stang","year":"2009","journal-title":"J Natl Cancer Inst"}],"container-title":["International Journal of Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ije\/article-pdf\/54\/6\/dyaf175\/65240582\/dyaf175.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ije\/article-pdf\/54\/6\/dyaf175\/65240582\/dyaf175.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T08:50:48Z","timestamp":1762678248000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ije\/article\/doi\/10.1093\/ije\/dyaf175\/8316722"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,14]]},"references-count":67,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,10,14]]}},"URL":"https:\/\/doi.org\/10.1093\/ije\/dyaf175","relation":{},"ISSN":["0300-5771","1464-3685"],"issn-type":[{"value":"0300-5771","type":"print"},{"value":"1464-3685","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,12]]},"published":{"date-parts":[[2025,10,14]]},"article-number":"dyaf175"}}