{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T08:45:30Z","timestamp":1777884330742,"version":"3.51.4"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"vor","delay-in-days":14,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010663","name":"European Research Council","doi-asserted-by":"publisher","award":["772244"],"award-info":[{"award-number":["772244"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic kidney disease (CKD) and chronic inflammation are highly prevalent in African populations, yet their relationship remains understudied. We examined the association between acute-phase reactants (C-reactive protein and ferritin) as markers of acute and chronic inflammation and the incidence of CKD 6\u2009years later in a prospective Ghanaian population-based cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data from the prospective Research on Obesity and Diabetes among African Migrants (RODAM-Pros) cohort were analysed and included participants living in rural and urban Ghana and Ghanaian migrants in the Netherlands. Acute-phase reactants were assessed between 2012 and 2015, while CKD incidence was assessed between 2019 and 2021 by using the race-free Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) 2021 equation. Robust Poisson regression models adjusted for potential confounders were used to assess associations. We explored interactions with age, sex, education, and geographical location, and stratified C-reactive protein (CRP) analyses by using established clinical cutoffs. The role of ferritin as an iron-storage marker was also evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 1435 participants, the baseline CRP was not associated with CKD incidence at follow-up [adjusted incidence rate ratio (aIRR) 1.02; 95% confidence interval (CI): 0.84\u20131.15]. Higher ferritin levels were associated with increased CKD risk (aIRR 3.53; 95% CI: 2.42\u20135.01) and albuminuria (aIRR 4.22; 95% CI: 2.87\u20136.10), but not with reduced estimated glomerular filtration rate (aIRR 0.99; 95% CI: 0.92\u20131.05). No effect modification was observed by age, sex, education, or geographical location. We found no evidence that iron overload or deficiency contributed to the ferritin\u2013CKD relationship.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Elevated ferritin levels, but not CRP levels, were associated with future CKD risk in Ghanaians. Multi-population prospective studies with repeated ferritin measurements are needed to better understand the links between ferritin, iron status, and CKD in African populations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ije\/dyag057","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T11:47:26Z","timestamp":1775044046000},"source":"Crossref","is-referenced-by-count":0,"title":["Acute-phase reactants as predictors of chronic kidney disease incidence in Africans: the population-based prospective RODAM cohort study"],"prefix":"10.1093","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3676-6924","authenticated-orcid":false,"given":"Muhulo M","family":"Mungamba","sequence":"first","affiliation":[{"name":"Department of Public and Occupational Health, Amsterdam Public Health Research institute, Amsterdam University Medical Centers, University of Amsterdam , Amsterdam,","place":["The Netherlands"]},{"name":"Department of Human 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Kumasi,","place":["Ghana"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karlijn A C","family":"Meeks","sequence":"additional","affiliation":[{"name":"Department of Public and Occupational Health, Amsterdam Public Health Research institute, Amsterdam University Medical Centers, University of Amsterdam , Amsterdam,","place":["The Netherlands"]},{"name":"Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health , Bethesda, MD,","place":["United States"]},{"name":"Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine , Baltimore, MD,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel N","family":"Darko","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, School of Medicine and Dentistry, Kwame Nkrumah University of Science and Technology , Kumasi,","place":["Ghana"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellis","family":"Owusu-Dabo","sequence":"additional","affiliation":[{"name":"Department of Global and International Health, School of Public Health, Kwame Nkrumah University of Science and Technology , Kumasi,","place":["Ghana"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liffert","family":"Vogt","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Section Nephrology, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam , Amsterdam,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0943-4393","authenticated-orcid":false,"given":"Bert-Jan","family":"Van Den Born","sequence":"additional","affiliation":[{"name":"Department of Public and Occupational Health, Amsterdam Public Health Research institute, Amsterdam University Medical Centers, University of 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