{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T07:05:54Z","timestamp":1790233554896,"version":"4.1.0"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"vor","delay-in-days":2,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Kadoorie Charitable Foundation in Hong Kong","award":["212946\/Z\/18\/Z"],"award-info":[{"award-number":["212946\/Z\/18\/Z"]}],"id":[{"id":"https:\/\/ror.org\/03r5nvr96","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Kadoorie Charitable Foundation in Hong Kong","award":["202922\/Z\/16\/Z"],"award-info":[{"award-number":["202922\/Z\/16\/Z"]}],"id":[{"id":"https:\/\/ror.org\/03r5nvr96","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Kadoorie Charitable Foundation in Hong Kong","award":["104085\/Z\/14\/Z"],"award-info":[{"award-number":["104085\/Z\/14\/Z"]}],"id":[{"id":"https:\/\/ror.org\/03r5nvr96","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Adiposity is associated with increased risk of breast cancer in post-menopausal women, while the association appears to be the inverse among premenopausal women in Western populations, but is unclear for Chinese women.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using data on 284\u2009538 women with no history of cancer, hysterectomy, oophorectomy, or breast surgery at baseline in 2004\u20138 from the China Kadoorie Biobank (a prospective cohort study), Cox regression was used to estimate adjusted hazard ratios (HRs) for breast cancer and its subtypes by measured body mass index (BMI) and other adiposity measures (waist circumference, fat percentage, waist\u2013hip ratio, fat mass) and by self-reported BMI at age 25\u2009years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Mean BMI was 23.8 (3.5 SD) kg\/m2 at baseline (mean age 51.4\u2009years) and 21.9 (2.7 SD) kg\/m2 at age 25\u2009years. During 10\u2009years of follow-up, there were 2379 incident breast cancer cases. Higher BMI was associated with a higher risk of breast cancer in women who were post-menopausal [HR = 1.35, 95% confidence interval (CI) 1.24\u20131.47] and premenopausal (HR = 1.13, 95% CI 1.03\u20131.24) at baseline, but not when censoring at age 50\u2009years to capture mainly premenopausal cancers. Among post-menopausal women, BMI was associated with oestrogen-receptor positive (ER ) (HR = 1.47, 95% CI 1.24\u20131.74), but not with oestrogen-receptor negative (ER\u2212) breast cancer (HR = 1.02, 95% CI 0.75\u20131.37). Waist circumference and fat percentage were associated with a higher risk of breast cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this cohort of Chinese women, higher levels of general and central adiposity were associated with a higher risk of breast cancer, in both women who were premenopausal and women who were post-menopausal at baseline. Among post-menopausal women, adiposity was associated with ER\u2009 \u2009but not ER\u2009\u2212\u2009breast cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ije\/dyag155","type":"journal-article","created":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T11:33:36Z","timestamp":1785670416000},"source":"Crossref","is-referenced-by-count":0,"title":["Adiposity and risk of breast cancer in 280\u2009000 Chinese women: a prospective cohort study"],"prefix":"10.1093","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3981-3418","authenticated-orcid":false,"given":"Christiana","family":"Kartsonaki","sequence":"first","affiliation":[{"name":"Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, Big Data Institute Building, University of Oxford , Oxford,","place":["United 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