{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:56:02Z","timestamp":1791305762622,"version":"4.3.1"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":49,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG075208-01-A"],"award-info":[{"award-number":["R01AG075208-01-A"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cancer mortality levels have declined across high-income countries, but progress has been uneven by cancer type. Examining birth-cohort patterns of lifestyle-related cancer mortality in an international context can shed light on how shared and differential global lifestyle transitions manifest differently across national contexts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We used harmonized cause-of-death data from the Human Cause of Death series of the Human Mortality Database for Canada, Czechia, England &amp; Wales, France, Germany, Japan, Spain, and the USA from 2000 to 2020. We examined mortality from lung and larynx, colorectal, stomach, and liver cancer for ages 30\u201384\u00a0years by using rates of mortality improvement displayed on Lexis surfaces. Single-age death rates were estimated from grouped data by using penalized composite link models. Two-factor Poisson models and sex-stratified surfaces served as sensitivity analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>All eight countries showed declining age-standardized cancer mortality, but with diverging trends by cause and birth cohorts. Lung and larynx cancer declined broadly, with mortality patterns reflecting cohort cigarette-smoking histories. Colorectal cancer mortality increased among cohorts born after 1960 in the USA, Canada, and England &amp; Wales, with a similar but delayed pattern in France and Germany. Liver cancer mortality was higher for cohorts born in 1945\u201355 than for earlier and later cohorts in several countries, with a re-emerging adverse pattern among cohorts born in around 1970\u201380.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Birth-cohort patterns in lifestyle-associated cancer mortality differ across national contexts. Worsening colorectal and liver cancer trends among younger cohorts call for increased prevention and screening strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ije\/dyag198","type":"journal-article","created":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T11:43:44Z","timestamp":1787399024000},"source":"Crossref","is-referenced-by-count":0,"title":["Evolution of birth-cohort patterns in lifestyle-associated cancer mortality across high-income countries"],"prefix":"10.1093","volume":"55","author":[{"given":"Octavio N","family":"Bramajo","sequence":"first","affiliation":[{"name":"Institute for Evolutionary Medicine, University of Z\u00fcrich , Z\u00fcrich,","place":["Switzerland"]},{"name":"Aarhus Institute for Advanced Studies (AIAS), Aarhus University , Aarhus C,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8766-0903","authenticated-orcid":false,"given":"Leah R","family":"Abrams","sequence":"additional","affiliation":[{"name":"Department of Community Health, Tufts University , Boston, MA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6671-8435","authenticated-orcid":false,"given":"Neil K","family":"Mehta","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of Texas Medical Branch , Galveston, TX,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,10,6]]},"reference":[{"key":"2026100612274401500_dyag198-B1","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3322\/caac.21871","article-title":"Cancer statistics, 2025","volume":"75","author":"Siegel","year":"2025","journal-title":"CA A Cancer J Clinicians"},{"key":"2026100612274401500_dyag198-B2","author":"Soerjomataram","year":"2020"},{"key":"2026100612274401500_dyag198-B3","doi-asserted-by":"publisher","first-page":"1100","DOI":"10.1016\/j.socscimed.2009.12.018","article-title":"What is a cohort effect? 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