{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T20:14:20Z","timestamp":1792700060206,"version":"4.5.0"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,6]]},"DOI":"10.1093\/ije\/dyr216","type":"journal-article","created":{"date-parts":[[2012,1,29]],"date-time":"2012-01-29T01:43:58Z","timestamp":1327801438000},"page":"753-761","source":"Crossref","is-referenced-by-count":54,"title":["Early life exposure to farm animals and symptoms of asthma, rhinoconjunctivitis and eczema: an ISAAC Phase Three Study"],"prefix":"10.1093","volume":"41","author":[{"given":"Bert","family":"Brunekreef","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Von Mutius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary K","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph A","family":"Odhiambo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadd O","family":"Clayton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,1,27]]},"reference":[{"key":"key\n\t\t\t\t20170503071035_dyr216-B1","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1038\/nri2871","article-title":"Farm living: effects on childhood asthma and allergy","volume":"10","author":"von Mutius","year":"2010","journal-title":"Nat Rev Immunol"},{"key":"key\n\t\t\t\t20170503071035_dyr216-B2","doi-asserted-by":"crossref","first-page":"325","DOI":"10.2500\/aap.2006.27.2874","article-title":"Identification of asthma risk factors in Mexico City in an International Study of Asthma and Allergy in Childhood survey","volume":"27","author":"Del-Rio-Navarro","year":"2006","journal-title":"Allergy Asthma Proc"},{"key":"key\n\t\t\t\t20170503071035_dyr216-B3","first-page":"10","article-title":"The international study of asthma and allergies in childhood (ISAAC): phase three rationale and methods","volume":"9","author":"Ellwood","year":"2005","journal-title":"Int J Tuberc Lung Dis"},{"key":"key\n\t\t\t\t20170503071035_dyr216-B4","first-page":"1225","article-title":"The International Study of Asthma and Allergies in Childhood (ISAAC) Steering Committee","volume":"351","author":"Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema: ISAAC","year":"1998","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20170503071035_dyr216-B5","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/S0140-6736(06)69283-0","article-title":"Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveys","volume":"368","author":"Asher","year":"2006","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20170503071035_dyr216-B6","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1136\/thx.2008.106609","article-title":"Global variation in the prevalence and severity of asthma symptoms: phase three of the International Study of Asthma and Allergies in Childhood (ISAAC)","volume":"64","author":"Lai","year":"2009","journal-title":"Thorax"},{"key":"key\n\t\t\t\t20170503071035_dyr216-B7","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1093\/ije\/dyn039","article-title":"International correlations between indicators of prevalence, hospital admissions and mortality for asthma in children","volume":"37","author":"Anderson","year":"2008","journal-title":"Int J Epidemiol"},{"key":"key\n\t\t\t\t20170503071035_dyr216-B8","first-page":"1174","article-title":"Translation of questions: the International Study of Asthma and Allergies in Childhood (ISAAC) experience","volume":"13","author":"Ellwood","year":"2009","journal-title":"Int J Tuberc Lung Dis"},{"key":"key\n\t\t\t\t20170503071035_dyr216-B9","volume-title":"World Bank GNI per capita Operational Guidelines and Analytical Classifications","author":"World Bank","year":"2006"},{"key":"key\n\t\t\t\t20170503071035_dyr216-B10","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1056\/NEJMoa020057","article-title":"Environmental exposure to endotoxin and its relation to asthma in school-age children","volume":"347","author":"Braun-Fahrlander","year":"2002","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20170503071035_dyr216-B11","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/S0140-6736(01)06252-3","article-title":"Exposure to farming in early life and development of asthma and allergy: a cross-sectional survey","volume":"358","author":"Riedler","year":"2001","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20170503071035_dyr216-B12","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1016\/j.jaci.2007.01.037","article-title":"Not all farming environments protect against the development of asthma and wheeze in children","volume":"119","author":"Ege","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"key\n\t\t\t\t20170503071035_dyr216-B13","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1111\/j.1398-9995.2005.00939.x","article-title":"Allergic diseases and atopic sensitization in children related to farming and anthroposophic lifestyle\u2013the PARSIFAL study","volume":"61","author":"Alfven","year":"2006","journal-title":"Allergy"},{"key":"key\n\t\t\t\t20170503071035_dyr216-B14","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1111\/j.1365-2222.2006.02640.x","article-title":"Inverse association of farm milk consumption with asthma and allergy in rural and suburban populations across Europe","volume":"37","author":"Waser","year":"2007","journal-title":"Clin Exp Allergy"},{"key":"key\n\t\t\t\t20170503071035_dyr216-B15","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1056\/NEJMoa1007302","article-title":"Exposure to environmental microorganisms and childhood asthma","volume":"364","author":"Ege","year":"2011","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20170503071035_dyr216-B16","first-page":"207","article-title":"Asthma and asthma-related symptoms in 16\u2009789 Chinese children in relation to pet keeping and parental atopy","volume":"18","author":"Dong","year":"2008","journal-title":"J Investig Allergol Clin Immunol"},{"key":"key\n\t\t\t\t20170503071035_dyr216-B17","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1136\/thorax.56.6.477","article-title":"Asthma and indoor environment in Nepal","volume":"56","author":"Melsom","year":"2001","journal-title":"Thorax"},{"key":"key\n\t\t\t\t20170503071035_dyr216-B18","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1111\/j.1365-2222.2009.03205.x","article-title":"The low prevalence of allergic disease in Eastern Europe: are risk factors consistent with the hygiene hypothesis?","volume":"39","author":"Kramer","year":"2009","journal-title":"Clin Exp Allergy"},{"key":"key\n\t\t\t\t20170503071035_dyr216-B19","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/1476-069X-7-28","article-title":"Exposure to animals and the risk of allergic asthma: a population-based cross-sectional study in Finnish and Russian children","volume":"7","author":"Hugg","year":"2008","journal-title":"Environ Health"},{"key":"key\n\t\t\t\t20170503071035_dyr216-B20","volume-title":"Livestock keeping in urban areas","author":"Schiere","year":"2001"},{"key":"key\n\t\t\t\t20170503071035_dyr216-B21","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.rmed.2008.09.017","article-title":"Horse allergens: an underestimated risk for allergic sensitization in an urban atopic population without occupational exposure","volume":"103","author":"Liccardi","year":"2009","journal-title":"Respir Med"},{"key":"key\n\t\t\t\t20170503071035_dyr216-B22","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1164\/rccm.200607-994OC","article-title":"Atopic sensitization and the international variation of asthma symptom prevalence in children","volume":"176","author":"Weinmayr","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"key":"key\n\t\t\t\t20170503071035_dyr216-B23","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1183\/09031936.00157807","article-title":"International variation in prevalence of rhinitis and its relationship with sensitisation to perennial and seasonal allergens","volume":"32","author":"Weinmayr","year":"2008","journal-title":"Eur Respir J"},{"key":"key\n\t\t\t\t20170503071035_dyr216-B24","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1159\/000265536","article-title":"Occupational endotoxin exposure reduces the risk of atopic sensitization but increases the risk of bronchial hyperresponsiveness","volume":"152","author":"Smit","year":"2010","journal-title":"Int Arch Allergy Immunol"},{"key":"key\n\t\t\t\t20170503071035_dyr216-B25","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.jaci.2007.03.037","article-title":"Exposure to dust mite allergen and endotoxin in early life and asthma and atopy in childhood","volume":"120","author":"Celedon","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"key\n\t\t\t\t20170503071035_dyr216-B26","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1046\/j.1442-200X.2001.01421.x","article-title":"Toxocara seroprevalence and childhood asthma among Malaysian children","volume":"43","author":"Chan","year":"2001","journal-title":"Pediatr Int"},{"key":"key\n\t\t\t\t20170503071035_dyr216-B27","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1093\/tropej\/fml083","article-title":"Bottle feeding and exposure to Toxocara as risk factors for wheezing illness among under-five Amazonian children: a population-based cross-sectional study","volume":"53","author":"Ferreira","year":"2007","journal-title":"J Trop Pediatr"},{"key":"key\n\t\t\t\t20170503071035_dyr216-B28","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.ijpara.2010.09.006","article-title":"Toxocara infection and diminished lung function in a nationally representative sample from the United States population","volume":"41","author":"Walsh","year":"2011","journal-title":"Int J Parasitol"},{"key":"key\n\t\t\t\t20170503071035_dyr216-B29","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1007\/s10096-009-0785-6","article-title":"Prevalence of antibodies against Ascaris suum and its association with allergic manifestations in 4-year-old children in The Netherlands: the PIAMA birth cohort study","volume":"28","author":"Pinelli","year":"2009","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"key\n\t\t\t\t20170503071035_dyr216-B30","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1136\/vr.121.10.213","article-title":"Prevalence of chlamydia, toxoplasma, toxocara and ringworm in farm cats in south-west England","volume":"121","author":"Gethings","year":"1987","journal-title":"Vet Rec"},{"key":"key\n\t\t\t\t20170503071035_dyr216-B31","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.vetpar.2004.08.015","article-title":"Prevalence of antibodies to Toxoplasma gondii and intestinal parasites in stray, farm and household cats in Spain","volume":"126","author":"Miro","year":"2004","journal-title":"Vet Parasitol"},{"key":"key\n\t\t\t\t20170503071035_dyr216-B32","doi-asserted-by":"crossref","first-page":"248","DOI":"10.2500\/ajr.2007.21.2990","article-title":"Relationship between Toxocara seropositivity and allergic rhinitis","volume":"21","author":"Yariktas","year":"2007","journal-title":"Am J Rhinol"},{"key":"key\n\t\t\t\t20170503071035_dyr216-B33","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1159\/000018493","article-title":"Skin manifestations associated with toxocariasis: a case-control study","volume":"201","author":"Humbert","year":"2000","journal-title":"Dermatology."},{"key":"key\n\t\t\t\t20170503071035_dyr216-B34","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.vetpar.2008.11.002","article-title":"Severe infection of adult dogs with helminths in Hunan Province, China poses significant public health concerns","volume":"160","author":"Dai","year":"2009","journal-title":"Vet Parasitol"}],"container-title":["International Journal of Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ije\/article\/41\/3\/753\/829730\/Early-life-exposure-to-farm-animals-and-symptoms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,20]],"date-time":"2017-06-20T13:27:17Z","timestamp":1497965237000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ije\/article-lookup\/doi\/10.1093\/ije\/dyr216"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1,27]]},"references-count":34,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2012,1,27]]},"published-print":{"date-parts":[[2012,6]]}},"URL":"https:\/\/doi.org\/10.1093\/ije\/dyr216","relation":{},"ISSN":["1464-3685","0300-5771"],"issn-type":[{"value":"1464-3685","type":"electronic"},{"value":"0300-5771","type":"print"}],"subject":[],"published":{"date-parts":[[2012,1,27]]}}}