{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T03:14:05Z","timestamp":1792466045171,"version":"4.5.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2018,10,17]],"date-time":"2018-10-17T00:00:00Z","timestamp":1539734400000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,12,1]]},"DOI":"10.1093\/ije\/dyy217","type":"journal-article","created":{"date-parts":[[2018,9,19]],"date-time":"2018-09-19T00:33:59Z","timestamp":1537317239000},"page":"1846-1854","source":"Crossref","is-referenced-by-count":186,"title":["Silicone breast implants and the risk of autoimmune\/rheumatic disorders: a real-world analysis"],"prefix":"10.1093","volume":"47","author":[{"given":"Abdulla","family":"Watad","sequence":"first","affiliation":[{"name":"Department of Medicine \u2018B\u2019, Sheba Medical Center, Tel-Hashomer, Israel"},{"name":"The Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel"},{"name":"Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vered","family":"Rosenberg","sequence":"additional","affiliation":[{"name":"Epidemiology and Database Research, Maccabi Healthcare Services, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1748-4297","authenticated-orcid":false,"given":"Shmuel","family":"Tiosano","sequence":"additional","affiliation":[{"name":"Department of Medicine \u2018B\u2019, Sheba Medical Center, Tel-Hashomer, Israel"},{"name":"The Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel"},{"name":"Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Willem","family":"Cohen Tervaert","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine and Dentistry, University of Alberta, Edmonton, Canada"},{"name":"Department of Medicine and Immunology, University of Maastricht, Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yarden","family":"Yavne","sequence":"additional","affiliation":[{"name":"Department of Medicine \u2018B\u2019, Sheba Medical Center, Tel-Hashomer, Israel"},{"name":"The Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel"},{"name":"Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yehuda","family":"Shoenfeld","sequence":"additional","affiliation":[{"name":"The Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel"},{"name":"Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varda","family":"Shalev","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel"},{"name":"Epidemiology and Database Research, Maccabi Healthcare Services, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Chodick","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel"},{"name":"Epidemiology and Database Research, Maccabi Healthcare Services, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard","family":"Amital","sequence":"additional","affiliation":[{"name":"Department of Medicine \u2018B\u2019, Sheba Medical Center, Tel-Hashomer, Israel"},{"name":"The Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel"},{"name":"Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,10,16]]},"reference":[{"key":"key\n\t\t\t\t2018120510035422100_dyy217-B1","first-page":"94","article-title":"The chemistry of silica and its potential health benefits","volume":"11","author":"Martin","year":"2007","journal-title":"J Nutr Health Aging"},{"key":"key\n\t\t\t\t2018120510035422100_dyy217-B2","doi-asserted-by":"crossref","first-page":"1.","DOI":"10.1155\/2013\/316783","article-title":"Silicon: a review of its potential role in the prevention and treatment of postmenopausal osteoporosis","volume":"2013","author":"Price","year":"2013","journal-title":"Int J Endocrinol"},{"key":"key\n\t\t\t\t2018120510035422100_dyy217-B3","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1097\/00006534-200202000-00049","article-title":"The silicone gel-filled breast implant controversy: an update","volume":"109","author":"Muzaffar","year":"2002","journal-title":"Plast Reconstr Surg"},{"key":"key\n\t\t\t\t2018120510035422100_dyy217-B4","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1586\/17434440.2016.1134310","article-title":"A review of the use of silicone implants in breast surgery","volume":"13","author":"Chao","year":"2016","journal-title":"Expert Rev Med Devices"},{"key":"key\n\t\t\t\t2018120510035422100_dyy217-B5","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1097\/BOR.0000000000000391","article-title":"Silicone breast implants and autoimmune rheumatic diseases: myth or reality","volume":"29","author":"Cohen Tervaert","year":"2017","journal-title":"Curr Opin Rheumatol"},{"key":"key\n\t\t\t\t2018120510035422100_dyy217-B6","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1177\/074823379200800606","article-title":"Immune functional impairment in patients with clinical abnormalities and silicone breast implants","volume":"8","author":"Vojdani","year":"1992","journal-title":"Toxicol Ind Health"},{"key":"key\n\t\t\t\t2018120510035422100_dyy217-B7","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1007\/s12026-016-8821-y","article-title":"Two hundred cases of ASIA syndrome following silicone implants: a comparative study of 30 years and a review of current literature","volume":"65","author":"Colaris","year":"2017","journal-title":"Immunol Res"},{"key":"key\n\t\t\t\t2018120510035422100_dyy217-B8","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/j.1365-2362.2010.02389.x","article-title":"Silicone and autoimmunity","volume":"41","author":"Hajdu","year":"2011","journal-title":"Eur J Clin Invest"},{"key":"key\n\t\t\t\t2018120510035422100_dyy217-B9","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1136\/bmj.316.7129.417","article-title":"Risk of connective tissue disease and related disorders among women with breast implants: a nation-wide retrospective cohort study in Sweden","volume":"316","author":"Nyren","year":"1998","journal-title":"BMJ"},{"key":"key\n\t\t\t\t2018120510035422100_dyy217-B10","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1056\/NEJM200003163421105","article-title":"Meta-analyses of the relation between silicone breast implants and the risk of connective-tissue diseases","volume":"342","author":"Janowsky","year":"2000","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2018120510035422100_dyy217-B11","doi-asserted-by":"crossref","first-page":"e1000336.","DOI":"10.1371\/journal.pmed.1000336","article-title":"Persistence with statins and onset of rheumatoid arthritis: a population-based cohort study","volume":"7","author":"Chodick","year":"2010","journal-title":"PLoS Med"},{"key":"key\n\t\t\t\t2018120510035422100_dyy217-B12","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1111\/bjd.13850","article-title":"Adherence to statins and the risk of psoriasis: a population-based cohort study","volume":"173","author":"Chodick","year":"2015","journal-title":"Br J Dermatol"},{"key":"key\n\t\t\t\t2018120510035422100_dyy217-B13","year":"2004"},{"key":"key\n\t\t\t\t2018120510035422100_dyy217-B14","doi-asserted-by":"crossref","first-page":"164","DOI":"10.7326\/M15-1169","article-title":"Long-term health outcomes in women with silicone gel breast implants: a systematic review","volume":"164","author":"Balk","year":"2016","journal-title":"Ann Intern Med"},{"key":"key\n\t\t\t\t2018120510035422100_dyy217-B15","first-page":"2215","article-title":"The influence of silicone implantation on murine lupus in MRL lpr\/lpr mice","volume":"26","author":"Schaefer","year":"1999","journal-title":"J Rheumatol"},{"key":"key\n\t\t\t\t2018120510035422100_dyy217-B16","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1006\/clin.1998.4532","article-title":"Silicone gel enhances the development of autoimmune disease in New Zealand black mice but fails to induce it in BALB\/cAnPt mice","volume":"87","author":"McDonald","year":"1998","journal-title":"Clin Immunol Immunopathol"},{"key":"key\n\t\t\t\t2018120510035422100_dyy217-B17","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1136\/ard.58.8.503","article-title":"Influence of long term silicone implantation on type II collagen induced arthritis in mice","volume":"58","author":"Schaefer","year":"1999","journal-title":"Ann Rheum Dis"},{"key":"key\n\t\t\t\t2018120510035422100_dyy217-B18","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1001\/jama.1996.03530320040032","article-title":"Self-reported breast implants and connective-tissue diseases in female health professionals: a retrospective cohort study","volume":"275","author":"Hennekens","year":"1996","journal-title":"JAMA"},{"key":"key\n\t\t\t\t2018120510035422100_dyy217-B19","first-page":"239","article-title":"Silicone gel filled breast implants and connective tissue disease: an overview","volume":"21","author":"Spiera","year":"1994","journal-title":"J Rheumatol"},{"key":"key\n\t\t\t\t2018120510035422100_dyy217-B20","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1177\/0961203314562622","article-title":"Severe ASIA syndrome associated with lymph node, thoracic, and pulmonary silicone infiltration following breast implant rupture: experience with four cases","volume":"24","author":"Nesher","year":"2015","journal-title":"Lupus"},{"key":"key\n\t\t\t\t2018120510035422100_dyy217-B21","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.ad.2012.07.007","article-title":"Foreign body granulomatous reaction to silica, silicone, and hyaluronic acid in a patient with interferon-induced sarcoidosis","volume":"104","author":"Novoa","year":"2013","journal-title":"Actas Dermosifiliogr"},{"key":"key\n\t\t\t\t2018120510035422100_dyy217-B22","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.immuni.2010.10.002","article-title":"Vaccine adjuvants: putting innate immunity to work","volume":"33","author":"Coffman","year":"2010","journal-title":"Immunity"},{"key":"key\n\t\t\t\t2018120510035422100_dyy217-B23","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s12026-016-8819-5","article-title":"Adjuvants- and vaccines-induced autoimmunity: animal models","volume":"65","author":"Ruiz","year":"2017","journal-title":"Immunol Res"},{"key":"key\n\t\t\t\t2018120510035422100_dyy217-B24","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1007\/s10067-017-3748-9","article-title":"The autoimmune\/inflammatory syndrome induced by adjuvants (ASIA)\/Shoenfeld\u2019s syndrome: descriptive analysis of 300 patients from the international ASIA syndrome registry","volume":"37","author":"Watad","year":"2018","journal-title":"Clin Rheumatol"},{"key":"key\n\t\t\t\t2018120510035422100_dyy217-B25","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1258\/ebm.2012.012151","article-title":"The periprosthetic capsule and connective tissue diseases: a piece in the puzzle of autoimmune\/autoinflammatory syndrome induced by adjuvants","volume":"237","author":"Bassetto","year":"2012","journal-title":"Exp Biol Med (Maywood)"},{"key":"key\n\t\t\t\t2018120510035422100_dyy217-B26","first-page":"73","article-title":"A comparison of autoantibody production in asymptomatic and symptomatic women with silicone breast implants","volume":"26","author":"Zandman-Goddard","year":"1999","journal-title":"J Rheumatol"},{"key":"key\n\t\t\t\t2018120510035422100_dyy217-B27","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1006\/jaut.1995.0020","article-title":"Multiple autoantibodies in patients with silicone breast implants","volume":"8","author":"Bar-Meir","year":"1995","journal-title":"J Autoimmun"},{"key":"key\n\t\t\t\t2018120510035422100_dyy217-B28","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S1081-1206(10)63102-X","article-title":"Cellular immune reactivities in women with silicone breast implants: a preliminary investigation","volume":"79","author":"Ellis","year":"1997","journal-title":"Ann Allergy Asthma Immunol"},{"key":"key\n\t\t\t\t2018120510035422100_dyy217-B29","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s12026-016-8813-y","article-title":"Is explantation of silicone breast implants useful in patients with complaints?","volume":"65","author":"de Boer","year":"2017","journal-title":"Immunol Res"},{"key":"key\n\t\t\t\t2018120510035422100_dyy217-B30","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1056\/NEJM199406163302401","article-title":"Risk of connective-tissue diseases and other disorders after breast implantation","volume":"330","author":"Gabriel","year":"1994","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2018120510035422100_dyy217-B31","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1056\/NEJM199506223322502","article-title":"Silicone breast implants and the risk of connective-tissue diseases and symptoms","volume":"332","author":"Sanchez-Guerrero","year":"1995","journal-title":"N Engl J Med"}],"container-title":["International Journal of Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ije\/article-pdf\/47\/6\/1846\/27015855\/dyy217.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,24]],"date-time":"2019-10-24T07:04:19Z","timestamp":1571900659000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ije\/article\/47\/6\/1846\/5133598"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,16]]},"references-count":31,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2018,10,16]]},"published-print":{"date-parts":[[2018,12,1]]}},"URL":"https:\/\/doi.org\/10.1093\/ije\/dyy217","relation":{},"ISSN":["0300-5771","1464-3685"],"issn-type":[{"value":"0300-5771","type":"print"},{"value":"1464-3685","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,12]]},"published":{"date-parts":[[2018,10,16]]}}}