{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T12:08:37Z","timestamp":1784722117705,"version":"3.55.0"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2019,5,17]],"date-time":"2019-05-17T00:00:00Z","timestamp":1558051200000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"French National Agency for Medicines"},{"name":"Health Products Safety"},{"name":"Agence Nationale de S\u00e9curit\u00e9 du M\u00e9dicament - ANSM"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Isotretinoin is the only effective treatment for severe acne. An isotretinoin-related suicide risk is still debated and under scrutiny by regulatory agencies. Our objectives were: to assess the risk of suicide attempt before, during and after isotretinoin treatment; to detect any potential triggering effect of isotretinoin initiation on suicide attempt.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We implemented a cohort and nested case-time-control study of subjects treated with oral isotretinoin (course or initiation) aged 10\u201350\u2009years, using the Nationwide French Health Insurance data (2009\u20132016). The main outcome was hospitalized suicide attempt. Standardized incidence ratios for hospitalized suicide attempts were calculated before, during and after isotretinoin treatment. The number of isotretinoin initiations was compared in risk and control periods of 2 months using a case-time-control analysis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In all, 443\u00a0814 patients (median age 20.0\u2009years; interquartile range 17.0\u201327.0\u2009years) were exposed to isotretinoin, amounting to 244\u00a0154 person-years, with a marked seasonality for treatment initiation. Compared with the French general population, the occurrence of suicide attempts under isotretinoin treatment was markedly lower, with a standardized incidence ratio of 0.6 [95% confidence interval (CI) = 0.53\u20130.67]; the same applied, to a lesser extent, before and after isotretinoin treatment. In the case-time-control analysis, among cases of suicide attempt, 108 and 127 isotretinoin initiations were observed in the risk and control periods respectively (i.e. 0\u20132\u2009months and 2\u20134\u2009months before the date of suicide attempt). The comparison with the 1199 and 1253 initiations observed among matched controls in the same two periods yielded a case-time-control odds ratio of 0.89 (95% CI = 0.68\u20131.16). A sensitivity analysis using three-month periods and a complementary analysis adding completed suicides for case definition showed consistent results.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Compared with the general population, a lower risk of suicide attempt was observed among patients exposed to isotretinoin and there was no evidence for a triggering effect of isotretinoin initiation on suicide attempt. A selection of patients at lower risk for suicidal behaviour and appropriate treatment management could explain these findings. Risk management plans should therefore be maintained.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ije\/dyz093","type":"journal-article","created":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T15:15:55Z","timestamp":1555082155000},"page":"1623-1635","source":"Crossref","is-referenced-by-count":38,"title":["Risk of suicide attempt associated with isotretinoin: a nationwide cohort and nested case-time-control study"],"prefix":"10.1093","volume":"48","author":[{"given":"Catherine","family":"Droitcourt","sequence":"first","affiliation":[{"name":"Univ Rennes, EA 7449 REPERES [Pharmacoepidemiology and Health Services Research]"},{"name":"PEPS Research Consortium (Pharmacoepidemiology for Health Product Safety), Rennes, France"},{"name":"Department of Dermatology, CHU Rennes, Rennes, France"},{"name":"INSERM, CIC 1414, Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Nowak","sequence":"additional","affiliation":[{"name":"PEPS Research Consortium (Pharmacoepidemiology for Health Product Safety), Rennes, France"},{"name":"University of Bretagne Loire, University of Brest, France"},{"name":"INSERM CIC 1412, CHRU Brest, Brest, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Rault","sequence":"additional","affiliation":[{"name":"Univ Rennes, EA 7449 REPERES [Pharmacoepidemiology and Health Services Research]"},{"name":"PEPS Research Consortium (Pharmacoepidemiology for Health Product Safety), Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Happe","sequence":"additional","affiliation":[{"name":"Univ Rennes, EA 7449 REPERES [Pharmacoepidemiology and Health Services Research]"},{"name":"PEPS Research Consortium (Pharmacoepidemiology for Health Product Safety), Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9ranger","family":"Le Nautout","sequence":"additional","affiliation":[{"name":"Univ Rennes, EA 7449 REPERES [Pharmacoepidemiology and Health Services Research]"},{"name":"PEPS Research Consortium (Pharmacoepidemiology for Health Product Safety), Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Kerbrat","sequence":"additional","affiliation":[{"name":"Univ Rennes, EA 7449 REPERES [Pharmacoepidemiology and Health Services Research]"},{"name":"PEPS Research Consortium (Pharmacoepidemiology for Health Product Safety), Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Balusson","sequence":"additional","affiliation":[{"name":"Univ Rennes, EA 7449 REPERES [Pharmacoepidemiology and Health Services Research]"},{"name":"PEPS Research Consortium (Pharmacoepidemiology for Health Product Safety), Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Poizeau","sequence":"additional","affiliation":[{"name":"Univ Rennes, EA 7449 REPERES [Pharmacoepidemiology and Health Services Research]"},{"name":"PEPS Research Consortium (Pharmacoepidemiology for Health Product Safety), Rennes, France"},{"name":"Department of Dermatology, CHU Rennes, Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Travers","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, CHU Rennes, Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Marc","family":"Sapori","sequence":"additional","affiliation":[{"name":"Emergency Department, CHU Lyon, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Lagarde","sequence":"additional","affiliation":[{"name":"INSERM, ISPED, Bordeaux Population Health Research Center INSERM U219 \u2013 \u201cInjury Epidemiology Transport Occupation\u201d Team, Bordeaux Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gr\u00e9goire","family":"Rey","sequence":"additional","affiliation":[{"name":"C\u00e9piDc-INSERM, Le Kremlin-Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Guillot","sequence":"additional","affiliation":[{"name":"Department of Dermatology, CHU Montpellier, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Oger","sequence":"additional","affiliation":[{"name":"Univ Rennes, EA 7449 REPERES [Pharmacoepidemiology and Health Services Research]"},{"name":"PEPS Research Consortium (Pharmacoepidemiology for Health Product Safety), Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Dupuy","sequence":"additional","affiliation":[{"name":"Univ Rennes, EA 7449 REPERES [Pharmacoepidemiology and Health Services Research]"},{"name":"PEPS Research Consortium (Pharmacoepidemiology for Health Product Safety), Rennes, France"},{"name":"Department of Dermatology, CHU Rennes, Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,5,16]]},"reference":[{"key":"2019111511303458700_dyz093-B1","doi-asserted-by":"crossref","first-page":"S34","DOI":"10.1016\/S0190-9622(98)70442-6","article-title":"Recent findings in the epidemiologic evidence, classification, and subtypes of acne vulgaris","volume":"39","author":"White","year":"1998","journal-title":"J Am Acad Dermatol"},{"key":"2019111511303458700_dyz093-B2","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/j.1365-2230.2009.03340.x","article-title":"Acne prevalence and beyond: acne disability and its predictive factors among Chinese late adolescents in Hong Kong","volume":"35","author":"Law","year":"2010","journal-title":"Clin Exp Dermatol"},{"key":"2019111511303458700_dyz093-B3","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0140-6736(11)60321-8","article-title":"Acne vulgaris","volume":"379","author":"Williams","year":"2012","journal-title":"Lancet"},{"key":"2019111511303458700_dyz093-B4","doi-asserted-by":"crossref","first-page":"f2634.","DOI":"10.1136\/bmj.f2634","article-title":"Acne vulgaris","volume":"346","author":"Dawson","year":"2013","journal-title":"BMJ"},{"key":"2019111511303458700_dyz093-B5","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1111\/bjd.12912","article-title":"Epidemiology and extracutaneous comorbidities of severe\u00a0acne\u00a0in adolescence: a U.S. population-based study","volume":"170","author":"Silverberg","year":"2014","journal-title":"Br J Dermatol"},{"key":"2019111511303458700_dyz093-B6","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1136\/bmj.1.6171.1109","article-title":"Prevalence of facial acne vulgaris in late adolescence and in adults","volume":"1","author":"Cunliffe","year":"1979","journal-title":"Br Med J"},{"key":"2019111511303458700_dyz093-B7","first-page":"577","article-title":"Prevalence of facial acne in adults","volume":"41","author":"Goulden","year":"1999","journal-title":"J Am Acad Dermatol"},{"key":"2019111511303458700_dyz093-B8","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.jaad.2007.06.045","article-title":"The prevalence of acne in adults 20 years and older","volume":"58","author":"Collier","year":"2008","journal-title":"J Am Acad Dermatol"},{"key":"2019111511303458700_dyz093-B9","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1111\/bjd.12149","article-title":"Epidemiology of acne vulgaris","volume":"168","author":"Bhate","year":"2013","journal-title":"Br J Dermatol"},{"key":"2019111511303458700_dyz093-B10","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1056\/NEJM197902153000701","article-title":"Prolonged remissions of cystic and conglobate acne with 13-cis-retinoic acid","volume":"300","author":"Peck","year":"1979","journal-title":"N Engl J Med"},{"key":"2019111511303458700_dyz093-B11","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/S0190-9622(82)70063-5","article-title":"Isotretinoin versus placebo in the treatment of cystic\u00a0acne. A randomized double-blind study","volume":"6","author":"Peck","year":"1982","journal-title":"J Am Acad Dermatol"},{"key":"2019111511303458700_dyz093-B12","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/S0140-6736(80)92273-4","article-title":"13-cis retinoic acid and acne","volume":"2","author":"Jones","year":"1980","journal-title":"Lancet"},{"key":"2019111511303458700_dyz093-B13","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1111\/j.1365-2133.1983.tb03973.x","article-title":"A dose-response study of I3-cis-retinoic acid in\u00a0acne vulgaris","volume":"108","author":"Jones","year":"1983","journal-title":"Br J Dermatol"},{"key":"2019111511303458700_dyz093-B14","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/j.1365-2133.1984.tb04030.x","article-title":"Remission rates in\u00a0acne\u00a0patients treated with various doses of 13-cis-retinoic acid (isotretinoin)","volume":"111","author":"Jones","year":"1984","journal-title":"Br J Dermatol"},{"key":"2019111511303458700_dyz093-B15","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/S0190-9622(84)80100-0","article-title":"Isotretinoin therapy for acne: results of a multicenter dose-response study","volume":"10","author":"Strauss","year":"1984","journal-title":"J Am Acad Dermatol"},{"key":"2019111511303458700_dyz093-B16","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1111\/bjd.15843","article-title":"French Acne Guidelines Working Group and Centre of Evidence of Dermatology. Guidelines for the management of acne: recommendations from a French multidisciplinary group","volume":"177","author":"Le Cleach","year":"2017","journal-title":"Br J Dermatol"},{"key":"2019111511303458700_dyz093-B17","year":"2015"},{"key":"2019111511303458700_dyz093-B18","doi-asserted-by":"crossref","first-page":"1261.","DOI":"10.1111\/jdv.13776","article-title":"European\u00a0evidence-based (S3)\u00a0guideline\u00a0for the treatment of\u00a0acne\u2014update 2016\u2014short version","volume":"30","author":"Nast","year":"2016","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2019111511303458700_dyz093-B19","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/j.jaad.2015.12.037","article-title":"Guidelines of care for the management of acne vulgaris","volume":"74","author":"Zaenglein","year":"2016","journal-title":"J Am Acad Dermatol"},{"key":"2019111511303458700_dyz093-B20","doi-asserted-by":"crossref","first-page":"213.","DOI":"10.1001\/jama.2016.19280","article-title":"Clinical guidelines for management of\u00a0acne vulgaris-reply","volume":"317","author":"Roman","year":"2017","journal-title":"JAMA"},{"key":"2019111511303458700_dyz093-B21","doi-asserted-by":"crossref","first-page":"513.","DOI":"10.1016\/S0140-6736(83)90538-X","article-title":"Teratogenicity of\u00a0isotretinoin","volume":"2","author":"Rosa","year":"1983","journal-title":"Lancet"},{"key":"2019111511303458700_dyz093-B22","year":"2019"},{"key":"2019111511303458700_dyz093-B23"},{"key":"2019111511303458700_dyz093-B24","year":"2013"},{"key":"2019111511303458700_dyz093-B25","year":"2019"},{"key":"2019111511303458700_dyz093-B26","year":"2015"},{"key":"2019111511303458700_dyz093-B27","year":"2014"},{"key":"2019111511303458700_dyz093-B28","year":"2014"},{"key":"2019111511303458700_dyz093-B29","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1067\/mjd.2001.117730","article-title":"An analysis of reports of depression and suicide in patients treated with isotretinoin","volume":"45","author":"Wysowski","year":"2001","journal-title":"J Am Acad Dermatol"},{"key":"2019111511303458700_dyz093-B30","doi-asserted-by":"crossref","first-page":"37","DOI":"10.4088\/JCP.10r05993","article-title":"Retinoic acid and affective disorders: the evidence for an association","volume":"73","author":"Bremner","year":"2012","journal-title":"J Clin Psychiatry"},{"key":"2019111511303458700_dyz093-B31","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1046\/j.1365-2133.1998.02511.x","article-title":"Depression and suicidal ideation in dermatology patients with acne, alopecia areata, atopic dermatitis and psoriasis","volume":"139","author":"Gupta","year":"1998","journal-title":"Br J Dermatol"},{"key":"2019111511303458700_dyz093-B32","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1111\/j.1440-1754.2006.00979.x","article-title":"Acne, anxiety, depression and suicide in teenagers: a cross-sectional survey of New Zealand secondary school students","volume":"42","author":"Purvis","year":"2006","journal-title":"J Paediatr Child Health"},{"key":"2019111511303458700_dyz093-B33","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.jaad.2008.07.013","article-title":"Self-esteem and body satisfaction among late adolescents with\u00a0acne: results from a population survey","volume":"59","author":"Dalgard","year":"2008","journal-title":"J Am Acad Dermatol"},{"key":"2019111511303458700_dyz093-B34","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/jid.2010.264","article-title":"Suicidal ideation, mental health problems, and social impairment are increased in adolescents with acne: a population-based study","volume":"131","author":"Halvorsen","year":"2011","journal-title":"J Invest Dermatol"},{"key":"2019111511303458700_dyz093-B35","doi-asserted-by":"crossref","first-page":"290.","DOI":"10.1038\/jid.2010.375","article-title":"Consequences of psychological distress in adolescents with\u00a0acne","volume":"131","author":"Misery","year":"2011","journal-title":"J Invest Dermatol"},{"key":"2019111511303458700_dyz093-B36","doi-asserted-by":"crossref","first-page":"115","DOI":"10.3109\/09546634.2012.736021","article-title":"Increased frequency of Attention Deficit Hyperactivity Disorder (ADHD) in\u00a0acne\u00a0versus dermatologic controls: analysis of an epidemiologic database from the US","volume":"25","author":"Gupta","year":"2014","journal-title":"J Dermatolog Treat"},{"key":"2019111511303458700_dyz093-B37","doi-asserted-by":"crossref","first-page":"485","DOI":"10.2340\/00015555-1998","article-title":"Consequences of\u00a0acne\u00a0on stress, fatigue, sleep disorders and sexual activity: a population-based study","volume":"95","author":"Misery","year":"2015","journal-title":"Acta Derm Venereol"},{"key":"2019111511303458700_dyz093-B38","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1111\/bjd.13786","article-title":"Cumulative mental health consequences of acne: 23-year follow-up in a general population birth cohort study","volume":"175","author":"Ramrakha","year":"2016","journal-title":"Br J Dermatol"},{"key":"2019111511303458700_dyz093-B39","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1001\/archderm.136.10.1231","article-title":"Isotretinoin\u00a0use and risk of depression, psychotic symptoms, suicide, and attempted suicide","volume":"136","author":"Jick","year":"2000","journal-title":"Arch Dermatol"},{"key":"2019111511303458700_dyz093-B40","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1067\/S0190-9622(03)02087-5","article-title":"Isotretinoin and antidepressant pharmacotherapy: a prescription sequence symmetry analysis","volume":"49","author":"Hersom","year":"2003","journal-title":"J Am Acad Dermatol"},{"key":"2019111511303458700_dyz093-B41","doi-asserted-by":"crossref","first-page":"413.","DOI":"10.1016\/j.euroneuro.2005.11.006","article-title":"Increased use of mental health services related to\u00a0isotretinoin\u00a0treatment: a 5-year analysis","volume":"16","author":"Friedman","year":"2006","journal-title":"Eur Neuropsychopharmacol"},{"key":"2019111511303458700_dyz093-B42","doi-asserted-by":"crossref","first-page":"526","DOI":"10.4088\/JCP.v69n0403","article-title":"Isotretinoin\u00a0and the risk of depression in patients with acne vulgaris: a case-crossover study","volume":"69","author":"Azoulay","year":"2008","journal-title":"J Clin Psychiatry"},{"key":"2019111511303458700_dyz093-B43","doi-asserted-by":"crossref","first-page":"c5812.","DOI":"10.1136\/bmj.c5812","article-title":"Association of suicide attempts with acne and treatment with isotretinoin: retrospective Swedish cohort study","volume":"341","author":"Sundstr\u00f6m","year":"2010","journal-title":"BMJ"},{"key":"2019111511303458700_dyz093-B44","doi-asserted-by":"crossref","first-page":"S149","DOI":"10.1016\/j.respe.2017.05.004","article-title":"Value of a national administrative database to guide public decisions: from the syst\u00e8me national d'information interr\u00e9gimes de l'Assurance Maladie (SNIIRAM) to the syst\u00e8me national des donn\u00e9es de sant\u00e9 (SNDS) in France","volume":"65","author":"Tuppin","year":"2017","journal-title":"Rev Epidemiol Sante Publique"},{"key":"2019111511303458700_dyz093-B45","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1111\/fcp.12214","article-title":"Overview of drug data within French health insurance databases and implications for pharmacoepidemiological studies","volume":"30","author":"Palmaro","year":"2016","journal-title":"Fundam Clin Pharmacol"},{"key":"2019111511303458700_dyz093-B46","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1097\/00001648-199505000-00010","article-title":"The case-time-control design","volume":"6","author":"Suissa","year":"1995","journal-title":"Epidemiology"},{"key":"2019111511303458700_dyz093-B47"},{"key":"2019111511303458700_dyz093-B48","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1016\/j.jaad.2016.12.028","article-title":"Isotretinoin treatment for acne and risk of depression: a systematic review and meta-analysis","volume":"76","author":"Huang","year":"2017","journal-title":"J Am Acad Dermatol"},{"key":"2019111511303458700_dyz093-B49","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1176\/appi.ajp.162.5.983","article-title":"Functional brain imaging alterations in acne patients treated with\u00a0isotretinoin","volume":"162","author":"Bremner","year":"2005","journal-title":"AJP"},{"key":"2019111511303458700_dyz093-B50","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.pnpbp.2007.07.001","article-title":"The neurobiology of retinoic acid in affective disorders","volume":"32","author":"Bremner","year":"2008","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"2019111511303458700_dyz093-B51","doi-asserted-by":"crossref","first-page":"S51","DOI":"10.1002\/(SICI)1099-1557(199710)6:3+<S51::AID-PDS301>3.3.CO;2-J","article-title":"Case-crossover\u00a0and case-time-control designs as alternatives in pharmacoepidemiologic research","volume":"6","author":"Schneeweiss","year":"1997","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"2019111511303458700_dyz093-B52","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1097\/00001648-199807000-00016","article-title":"The\u00a0case-time-control\u00a0design: further assumptions and conditions","volume":"9","author":"Suissa","year":"1998","journal-title":"Epidemiology"},{"key":"2019111511303458700_dyz093-B53","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1146\/annurev.publhealth.21.1.193","article-title":"Should we use a\u00a0case-crossover\u00a0design?","volume":"21","author":"Maclure","year":"2000","journal-title":"Annu Rev Public Health"},{"key":"2019111511303458700_dyz093-B54","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.annepidem.2003.09.012","article-title":"Use of the case-crossover design to study prolonged drug exposures and insidious outcomes","volume":"14","author":"Wang","year":"2004","journal-title":"Ann Epidemiol"},{"key":"2019111511303458700_dyz093-B55","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1001\/archderm.144.9.1197","article-title":"Does\u00a0isotretinoin\u00a0increase the risk of depression?","volume":"144","author":"Bigby","year":"2008","journal-title":"Arch Dermatol"},{"key":"2019111511303458700_dyz093-B56","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1111\/j.1365-2133.2011.10369.x","article-title":"Acne, isotretinoin and suicide attempts: a critical appraisal","volume":"164","author":"Langan","year":"2011","journal-title":"Br J Dermatol"},{"key":"2019111511303458700_dyz093-B57","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1111\/j.1365-2133.2011.10371.x","article-title":"Commentary: acne, isotretinoin and suicide attempts","volume":"164","author":"Margolis","year":"2011","journal-title":"Br J Dermatol"}],"container-title":["International Journal of Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ije\/article-pdf\/48\/5\/1623\/30800652\/dyz093.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/ije\/article-pdf\/48\/5\/1623\/30800652\/dyz093.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,11,15]],"date-time":"2019-11-15T11:42:03Z","timestamp":1573818123000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ije\/article\/48\/5\/1623\/5490638"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,16]]},"references-count":57,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2019,5,16]]},"published-print":{"date-parts":[[2019,10,1]]}},"URL":"https:\/\/doi.org\/10.1093\/ije\/dyz093","relation":{},"ISSN":["0300-5771","1464-3685"],"issn-type":[{"value":"0300-5771","type":"print"},{"value":"1464-3685","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,10]]},"published":{"date-parts":[[2019,5,16]]}}}