{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T15:48:29Z","timestamp":1790264909008,"version":"4.1.0"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2019,10,19]],"date-time":"2019-10-19T00:00:00Z","timestamp":1571443200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 CA118914"],"award-info":[{"award-number":["R01 CA118914"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Ionizing radiation is a known cause of female breast cancer, but there have been few studies of the risk after prolonged radiation exposure at low dose rates.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This population-based case-control study estimated breast cancer risk after \u223c25 years\u2019 exposure to radiation from the Chernobyl accident. Cases (n\u2009=\u2009468) were women \u226455\u2009years old when first diagnosed with invasive breast cancer during October 2008 through \u2009February 2013, who lived in Bryansk Oblast, Russia at the time of the accident and their diagnoses. Controls, individually matched to cases on birth year, administrative district of residence and urban vs non-urban settlement during the accident, were women without breast cancer who lived in Bryansk Oblast at the time of the accident and on their cases\u2019 diagnosis dates (n\u2009=\u2009468). Subjects were interviewed regarding residence, dietary and food source histories to support individualized estimation of their radiation doses to the breast, which ranged from 0.04\u2009\u2212\u200941 centigray (cGy) (mean 1.3\u2009cGy).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In multivariable analyses, the odds ratio for breast cancer risk was 3.0 [95% confidence interval (CI): 1.3, 7.0] and 2.7 (95% CI: 1.0, 7.3) in the seventh and eighth dose octiles, respectively, relative to the lowest octile. Analyses of dose effect modification suggested that radiation-related risk may have been higher in women who were younger at the time of the accident and\/or at the time of diagnosis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This study suggests that prolonged exposure to ionizing radiation at low dose rates can increase risk of breast cancer.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ije\/dyz214","type":"journal-article","created":{"date-parts":[[2019,9,27]],"date-time":"2019-09-27T00:17:12Z","timestamp":1569543432000},"page":"448-456","source":"Crossref","is-referenced-by-count":23,"title":["Female breast cancer risk in Bryansk Oblast, Russia, following prolonged low dose rate exposure to radiation from the Chernobyl power station accident"],"prefix":"10.1093","volume":"49","author":[{"given":"Nikolai","family":"Rivkind","sequence":"first","affiliation":[{"name":"Bryansk Diagnostic Center, Bryansk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeriy","family":"Stepanenko","sequence":"first","affiliation":[{"name":"Medical Radiological Research Center, Obninsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Belukha","sequence":"first","affiliation":[{"name":"Medical Radiological Research Center, Obninsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie","family":"Guenthoer","sequence":"first","affiliation":[{"name":"Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth J","family":"Kopecky","sequence":"first","affiliation":[{"name":"Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergei","family":"Kulikov","sequence":"first","affiliation":[{"name":"National Research Center for Hematology, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Kurnosova","sequence":"first","affiliation":[{"name":"Bryansk Diagnostic Center, Bryansk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn","family":"Onstad","sequence":"first","affiliation":[{"name":"Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peggy","family":"Porter","sequence":"first","affiliation":[{"name":"Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikita","family":"Shklovskiy-Kordi","sequence":"first","affiliation":[{"name":"National Research Center for Hematology, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladislav","family":"Troshin","sequence":"first","affiliation":[{"name":"Bryansk Institute of Pathology, Bryansk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Voillequ\u00e9","sequence":"first","affiliation":[{"name":"MJP Risk Assessment, Denver, CO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Davis","sequence":"first","affiliation":[{"name":"Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA"},{"name":"Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,10,19]]},"reference":[{"key":"2020060215101577900_dyz214-B1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/bcr970","article-title":"Radiation and breast cancer: a review of current evidence","volume":"7","author":"Ronckers","year":"2004","journal-title":"Breast Cancer Res"},{"key":"2020060215101577900_dyz214-B2","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1080\/09553000902883836","article-title":"Ionizing radiation and cancer risks: what have we learned from epidemiology?","volume":"85","author":"Gilbert","year":"2009","journal-title":"Int J Radiat Biol"},{"key":"2020060215101577900_dyz214-B3","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1667\/RR3082","article-title":"Incidence of female breast cancer among atomic bomb survivors, Hiroshima and Nagasaki, 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