{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T21:46:39Z","timestamp":1777671999781,"version":"3.51.4"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2020,9,4]],"date-time":"2020-09-04T00:00:00Z","timestamp":1599177600000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,12,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The present multicenter study aimed at defining the clinical profile of patients with major depressive disorder (MDD) and comorbid migraine.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Demographic and clinical information for 1410 MDD patients with vs without concurrent migraine were compared by descriptive statistics, analyses of covariance, and binary logistic regression analyses.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The point prevalence rate for comorbid migraine was 13.5% for female and 6.2% for male patients. MDD\u2009+\u2009migraine patients were significantly younger, heavier, more likely female, of non-Caucasian origin, outpatient, and suffering from asthma. The presence of MDD\u2009+\u2009migraine resulted in a significantly higher functional disability. First-line antidepressant treatment strategy revealed a trend towards agomelatine. Second-generation antipsychotics were significantly less often administered for augmentation treatment in migraineurs. Overall, MDD\u2009+\u2009migraine patients tended to respond worse to their pharmacotherapy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Treatment guidelines for comorbid depression and migraine are warranted to ensure optimal efficacy and avoid possible pitfalls in psychopharmacotherapy, including serotonin syndrome.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ijnp\/pyaa035","type":"journal-article","created":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T16:21:40Z","timestamp":1589559700000},"page":"571-577","source":"Crossref","is-referenced-by-count":11,"title":["Clinical Correlates and Outcome of Major Depressive Disorder and Comorbid Migraine: A Report of the European Group for the Study of Resistant Depression"],"prefix":"10.1093","volume":"23","author":[{"given":"Gernot","family":"Fugger","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Dold","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucie","family":"Bartova","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marleen M M","family":"Mitschek","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Souery","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Libre de Bruxelles, Bruxelles, Belgium"},{"name":"Psy Pluriel Centre Europ\u00e9en de Psychologie M\u00e9dicale, Bruxelles, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julien","family":"Mendlewicz","sequence":"additional","affiliation":[{"name":"School of Medicine, Free University of Brussels, Bruxelles, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Serretti","sequence":"additional","affiliation":[{"name":"Department of Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Zohar","sequence":"additional","affiliation":[{"name":"Psychiatric Division, Chaim Sheba Medical Center, Tel Hashomer, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stuart","family":"Montgomery","sequence":"additional","affiliation":[{"name":"Imperial College, University of London, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Fabbri","sequence":"additional","affiliation":[{"name":"Department of Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy"},{"name":"Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King\u2019s College London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Frey","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siegfried","family":"Kasper","sequence":"additional","affiliation":[{"name":"Center for Brain Research, Medical University of Vienna, Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,9,4]]},"reference":[{"key":"2020120619344330400_CIT0001","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1080\/09540261.2017.1326882","article-title":"Depression comorbidity in migraine","volume":"29","author":"Amoozegar","year":"2017","journal-title":"Int Rev Psychiatry"},{"key":"2020120619344330400_CIT0002","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1093\/ijnp\/pyy009","article-title":"Major depression and the degree of suicidality: results of the European Group for the Study of Resistant Depression (GSRD)","volume":"21","author":"Bartova","year":"2018","journal-title":"Int J Neuropsychopharmacol"},{"key":"2020120619344330400_CIT0003","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1080\/15622975.2019.1635270","article-title":"Results of the European Group for the Study of Resistant Depression (GSRD) - 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