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However, whether the baseline functional connectivity of the frontostriatal network could predict the treatment outcome of low-dose ketamine infusion remains unknown.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In total, 48 patients with treatment-resistant depression were randomly divided into 3 treatment groups (a single-dose 40-minute i.v. infusion) as follows: 0.5 mg\/kg ketamine, 0.2 mg\/kg ketamine, and saline placebo infusion. Patients were subsequently followed-up for 2 weeks. Resting-state functional magnetic resonance imaging was performed for each patient before infusion administration. In addition, the baseline frontostriatal functional connectivity of patients with treatment-resistant depression was also compared with that of healthy controls.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Compared with the healthy controls, patients with treatment-resistant depression had a decreased functional connectivity in the frontostriatal circuits, especially between the right superior frontal cortex and executive region of the striatum and between the right paracingulate cortex and rostral-motor region of the striatum. The baseline hypoconnectivity of the bilateral superior frontal cortex to the executive region of the striatum was associated with a greater reduction of depression symptoms after a single 0.2-mg\/kg ketamine infusion.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Reduced connectivity of the superior frontal cortex to the striatum predicted the response to ketamine infusion among patients with treatment-resistant depression.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ijnp\/pyaa056","type":"journal-article","created":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T19:22:36Z","timestamp":1595445756000},"page":"791-798","source":"Crossref","is-referenced-by-count":29,"title":["Functional Dysconnectivity of Frontal Cortex to Striatum Predicts Ketamine Infusion Response in Treatment-Resistant Depression"],"prefix":"10.1093","volume":"23","author":[{"given":"Mu-Hong","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan"},{"name":"Division of Psychiatry, Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan"},{"name":"Institute of Brain Science, National Yang-Ming University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan-Chen","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan"},{"name":"Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan"},{"name":"Department of biomedical engineering, National Yang-Ming University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Chen","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Taipei Veterans General Hospital, 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