{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T23:53:56Z","timestamp":1787961236739,"version":"build-2784847793"},"reference-count":73,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2020,8,21]],"date-time":"2020-08-21T00:00:00Z","timestamp":1597968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"JSPS KAKENHI","award":["24791951"],"award-info":[{"award-number":["24791951"]}]},{"name":"JSPS KAKENHI","award":["17K11591"],"award-info":[{"award-number":["17K11591"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,12,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cocaine (benzoylmethylecgonine) is one of the most widely used illegal psychostimulant drugs worldwide, and mortality from acute intoxication is increasing. Suppressing hyperthermia is effective in reducing cocaine-related mortality, but a definitive therapy has not yet been found. In this study, we assessed the ability of risperidone to attenuate acute cocaine-induced hyperthermia and delineated the mechanism of its action.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Rats were injected i.p. with saline, risperidone, ketanserin, ritanserin, haloperidol, or SCH 23 390 before and after injection of cocaine (30 mg\/kg) or with WAY-00 635, SB 206\u2005553, or sulpiride before cocaine injection; thereafter, the rectal temperature was measured every 30 minutes for up to 4 hours. In vivo microdialysis was used to reveal the effect of risperidone on cocaine-induced elevation of dopamine (DA), serotonin (5-HT), and noradrenaline concentrations in the anterior hypothalamus. For post-administration experiments, saline or risperidone (0.5 mg\/kg) were injected into rats, and cocaine (30 mg\/kg) was injected 15 minutes later. For every 30 minutes thereafter, DA, 5-HT, and noradrenaline levels were measured for up to 240 minutes after cocaine administration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Risperidone, 5-HT2A receptor antagonists, and D1 receptor antagonistic drugs prevented and reversed cocaine-induced hyperthermia. In contrast, receptor antagonists for 5-HT1A, 5-HT2B\/2C, and D2 did not alter cocaine-induced hyperthermia. Risperidone treatment further attenuated cocaine-induced elevation of DA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our results indicate that risperidone attenuates cocaine-induced hyperthermia primarily by blocking the activities of the 5-HT2A and D1 receptors and may be potentially useful for treating cocaine-induced acute hyperthermia in humans.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ijnp\/pyaa065","type":"journal-article","created":{"date-parts":[[2020,8,15]],"date-time":"2020-08-15T07:10:44Z","timestamp":1597475444000},"page":"811-820","source":"Crossref","is-referenced-by-count":11,"title":["Risperidone and 5-HT2A Receptor Antagonists Attenuate and Reverse Cocaine-Induced Hyperthermia in Rats"],"prefix":"10.1093","volume":"23","author":[{"given":"Tsuyoshi","family":"Okada","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Jichi Medical University, Tochigi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsutoshi","family":"Shioda","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Jichi Medical University, Tochigi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Makiguchi","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Jichi Medical University, Tochigi, Japan"},{"name":"Department of Psychiatry, Sano Kosei General Hospital, Tochigi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiro","family":"Suda","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Jichi Medical University, Tochigi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,8,21]]},"reference":[{"key":"2020122903594562000_CIT0001","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s002130100704","article-title":"Effects of cocaine on extracellular dopamine and serotonin levels in the nucleus accumbens","volume":"155","author":"Andrews","year":"2001","journal-title":"Psychopharmacology (Berl)"},{"key":"2020122903594562000_CIT0002","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.drugalcdep.2017.04.019","article-title":"Association of elevated ambient temperature with death from cocaine overdose","volume":"178","author":"Auger","year":"2017","journal-title":"Drug Alcohol Depend"},{"key":"2020122903594562000_CIT0003","first-page":"210","article-title":"Fatal hyperthermia associated with cocaine use","volume":"150","author":"Bauwens","year":"1989","journal-title":"West J Med"},{"key":"2020122903594562000_CIT0004","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/0028-3908(94)90059-0","article-title":"Molecular biology of 5-HT receptors","volume":"33","author":"Boess","year":"1994","journal-title":"Neuropharmacology"},{"key":"2020122903594562000_CIT0005","doi-asserted-by":"crossref","first-page":"4380","DOI":"10.1021\/jm00022a004","article-title":"Enhanced D1 affinity in a series of piperazine ring substituted 1-piperazino-3-arylindans with potential atypical antipsychotic activity","volume":"38","author":"B\u00f8ges\u00f8","year":"1995","journal-title":"J Med Chem"},{"key":"2020122903594562000_CIT0006","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1111\/j.1360-0443.2009.02887.x","article-title":"Ambient temperature and risk of death from accidental drug overdose in New York City, 1990-2006","volume":"105","author":"Bohnert","year":"2010","journal-title":"Addiction"},{"key":"2020122903594562000_CIT0007","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1111\/j.1476-5381.1995.tb14977.x","article-title":"The pharmacology and distribution of human 5-hydroxytryptamine2B (5-HT2B) receptor gene products: comparison with 5-HT2A and 5-HT2C receptors","volume":"115","author":"Bonhaus","year":"1995","journal-title":"Br J Pharmacol"},{"key":"2020122903594562000_CIT0008","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1046\/j.1471-4159.2000.0751625.x","article-title":"Serotonin 5-HT(2) receptor stimulation of dopamine release in the posterior but not anterior nucleus accumbens of the rat","volume":"75","author":"Bowers","year":"2000","journal-title":"J Neurochem"},{"key":"2020122903594562000_CIT0009","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.pnpbp.2004.01.007","article-title":"Cocaine acts on accumbens monoamines and locomotor behavior via a 5-HT2A\/2C receptor mechanism as shown by ketanserin: 24-h follow-up studies","volume":"28","author":"Broderick","year":"2004","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"2020122903594562000_CIT0010","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/S0028-3908(02)00381-7","article-title":"Selective serotonin reuptake inhibitors enhance cocaine-induced locomotor activity and dopamine release in the nucleus accumbens","volume":"44","author":"Bubar","year":"2003","journal-title":"Neuropharmacology"},{"key":"2020122903594562000_CIT0011","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0893-133X(94)00129-N","article-title":"Radioreceptor binding profile of the atypical antipsychotic olanzapine","volume":"14","author":"Bymaster","year":"1996","journal-title":"Neuropsychopharmacology"},{"key":"2020122903594562000_CIT0012","doi-asserted-by":"crossref","first-page":"387","DOI":"10.5694\/j.1326-5377.1988.tb120678.x","article-title":"Cocaine abuse with hyperthermia, seizures and fatal complications","volume":"149","author":"Campbell","year":"1988","journal-title":"Med J Aust"},{"key":"2020122903594562000_CIT0013","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/S0892-0362(98)00004-X","article-title":"Enhancement of cocaine-induced hyperthermia fails to elicit neurotoxicity","volume":"20","author":"Cappon","year":"1998","journal-title":"Neurotoxicol Teratol"},{"key":"2020122903594562000_CIT0014","first-page":"350","article-title":"Acute cocaine intoxication in the conscious dog: studies on the mechanism of lethality","volume":"217","author":"Catravas","year":"1981","journal-title":"J Pharmacol Exp Ther"},{"key":"2020122903594562000_CIT0015","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s00213-010-1929-1","article-title":"Ventral and dorsal striatal dopamine efflux and behavior in rats with simple vs. co-morbid histories of cocaine sensitization and neonatal ventral hippocampal lesions","volume":"212","author":"Chambers","year":"2010","journal-title":"Psychopharmacology (Berl)"},{"key":"2020122903594562000_CIT0016","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1007\/s00213-006-0490-4","article-title":"WAY-100 635 is a potent dopamine D4 receptor agonist","volume":"188","author":"Chemel","year":"2006","journal-title":"Psychopharmacology (Berl)"},{"key":"2020122903594562000_CIT0017","first-page":"1597","article-title":"Autoregulation and monoamine interactions in the ventral tegmental area in the absence and presence of cocaine: a microdialysis study in freely moving rats","volume":"271","author":"Chen","year":"1994","journal-title":"J Pharmacol Exp Ther"},{"key":"2020122903594562000_CIT0018","doi-asserted-by":"crossref","first-page":"785","DOI":"10.7326\/0003-4819-136-11-200206040-00006","article-title":"Mechanism of cocaine-induced hyperthermia in humans","volume":"136","author":"Crandall","year":"2002","journal-title":"Ann Intern Med"},{"key":"2020122903594562000_CIT0019","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0006-8993(94)91570-9","article-title":"Regional extracellular norepinephrine responses to amphetamine and cocaine and effects of clonidine pretreatment","volume":"654","author":"Florin","year":"1994","journal-title":"Brain Res"},{"key":"2020122903594562000_CIT0020","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1002\/syn.20489","article-title":"Cocaine-induced dopamine overflow within the nucleus accumbens measured by in vivo microdialysis: a meta-analysis","volume":"62","author":"Frank","year":"2008","journal-title":"Synapse"},{"key":"2020122903594562000_CIT0021","doi-asserted-by":"crossref","first-page":"141","DOI":"10.3109\/15563650.2015.1115056","article-title":"Case series: toxicity from 25B-NBOMe\u2013a cluster of N-bomb cases","volume":"54","author":"Gee","year":"2016","journal-title":"Clin Toxicol (Phila)"},{"key":"2020122903594562000_CIT0022","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1097\/00001756-199301000-00028","article-title":"Cocaine alters body temperature and behavioral thermoregulatory responses","volume":"4","author":"Gonzalez","year":"1993","journal-title":"Neuroreport"},{"key":"2020122903594562000_CIT0023","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1016\/0006-2952(86)90308-4","article-title":"In situ molecular sizes of the various types of 5-HT binding sites in the rat brain","volume":"35","author":"Gozlan","year":"1986","journal-title":"Biochem Pharmacol"},{"key":"2020122903594562000_CIT0024","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/j.1600-0773.1986.tb00071.x","article-title":"Effects of remoxipride and some related new substituted salicylamides on rat brain receptors","volume":"58","author":"Hall","year":"1986","journal-title":"Acta Pharmacol Toxicol (Copenh)"},{"key":"2020122903594562000_CIT0025","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s00213-007-1007-5","article-title":"Interactions between ethanol and cocaine, amphetamine, or MDMA in the rat: thermoregulatory and locomotor effects","volume":"197","author":"Hamida","year":"2008","journal-title":"Psychopharmacology (Berl)"},{"key":"2020122903594562000_CIT0026","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1111\/j.1748-1716.1981.tb06837.x","article-title":"The effect of temperature elevation on the cerebrovascular response to noradrenaline and 5-hydroxytryptamine","volume":"112","author":"Hardebo","year":"1981","journal-title":"Acta Physiol Scand"},{"key":"2020122903594562000_CIT0027","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0304-3940(00)01276-3","article-title":"Alteration in dopamine metabolism in the thermoregulatory center of exercising rats","volume":"289","author":"Hasegawa","year":"2000","journal-title":"Neurosci Lett"},{"key":"2020122903594562000_CIT0028","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.jneumeth.2011.05.024","article-title":"Continuous monitoring of hypothalamic neurotransmitters and thermoregulatory responses in exercising rats","volume":"202","author":"Hasegawa","year":"2011","journal-title":"J Neurosci Methods"},{"key":"2020122903594562000_CIT0029","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.neulet.2017.05.030","article-title":"Involvement of serotonin in the ventral tegmental area in thermoregulation of freely moving rats","volume":"653","author":"Ishiwata","year":"2017","journal-title":"Neurosci Lett"},{"key":"2020122903594562000_CIT0030","first-page":"216","article-title":"The pharmacological characterization of a novel selective 5-hydroxytryptamine1A receptor antagonist, NAD-299","volume":"283","author":"Johansson","year":"1997","journal-title":"J Pharmacol Exp Ther"},{"key":"2020122903594562000_CIT0031","doi-asserted-by":"crossref","first-page":"5379","DOI":"10.1523\/JNEUROSCI.15-07-05379.1995","article-title":"D1 receptors modulate glutamate transmission in the ventral tegmental area","volume":"15","author":"Kalivas","year":"1995","journal-title":"J Neurosci"},{"key":"2020122903594562000_CIT0032","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/0361-9230(89)90108-1","article-title":"Microdialysis measurement of monoamine and amino acid release from the medial preoptic region of the sheep in response to heat exposure","volume":"22","author":"Kendrick","year":"1989","journal-title":"Brain Res Bull"},{"key":"2020122903594562000_CIT0033","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1111\/j.1476-5381.1996.tb15208.x","article-title":"In vitro and in vivo profile of SB 206\u2005553, a potent 5-HT2C\/5-HT2B receptor antagonist with anxiolytic-like properties","volume":"117","author":"Kennett","year":"1996","journal-title":"Br J Pharmacol"},{"key":"2020122903594562000_CIT0034","doi-asserted-by":"crossref","first-page":"335","DOI":"10.3109\/00952998809001555","article-title":"Rapid death during cocaine abuse: a variant of the neuroleptic malignant syndrome?","volume":"14","author":"Kosten","year":"1988","journal-title":"Am J Drug Alcohol Abuse"},{"key":"2020122903594562000_CIT0035","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/0166-2236(91)90141-G","article-title":"The dopamine hypothesis of the reinforcing properties of cocaine","volume":"14","author":"Kuhar","year":"1991","journal-title":"Trends Neurosci"},{"key":"2020122903594562000_CIT0036","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1056\/NEJM200108023450507","article-title":"Cardiovascular complications of cocaine use","volume":"345","author":"Lange","year":"2001","journal-title":"N Engl J Med"},{"key":"2020122903594562000_CIT0037","first-page":"R1260","article-title":"Changes in extracellular serotonin in rat hypothalamus affect thermoregulatory function","volume":"274","author":"Lin","year":"1998","journal-title":"Am J Physiol"},{"key":"2020122903594562000_CIT0038","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1097\/00000433-198607030-00012","article-title":"Fatal malignant hyperthermia associated with recreational cocaine and ethanol abuse","volume":"7","author":"Loghmanee","year":"1986","journal-title":"Am J Forensic Med Pathol"},{"key":"2020122903594562000_CIT0039","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1159\/000138648","article-title":"Cocaine and body temperature in the rat: effects of ambient temperature","volume":"40","author":"Lomax","year":"1990","journal-title":"Pharmacology"},{"key":"2020122903594562000_CIT0040","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1159\/000139042","article-title":"Cocaine and body temperature: effect of exercise at high ambient temperature","volume":"46","author":"Lomax","year":"1993","journal-title":"Pharmacology"},{"key":"2020122903594562000_CIT0041","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1113\/jphysiol.1982.sp014466","article-title":"The thermoregulatory effects of noradrenaline, serotonin and carbachol injected into the rat spinal subarachnoid space","volume":"333","author":"Lopachin","year":"1982","journal-title":"J Physiol"},{"key":"2020122903594562000_CIT0042","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1001\/jama.279.22.1795","article-title":"Ambient temperature and mortality from unintentional cocaine overdose","volume":"279","author":"Marzuk","year":"1998","journal-title":"JAMA"},{"key":"2020122903594562000_CIT0043","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/BF02245187","article-title":"Evidence that 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI)-induced hyperthermia in rats is mediated by stimulation of 5-HT2A receptors","volume":"117","author":"Mazzola-Pomietto","year":"1995","journal-title":"Psychopharmacology (Berl)"},{"key":"2020122903594562000_CIT0044","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S0166-4328(02)00042-6","article-title":"The selective serotonin(1A)-receptor antagonist WAY 100\u2005635 blocks behavioral stimulating effects of cocaine but not ventral striatal dopamine increase","volume":"134","author":"M\u00fcller","year":"2002","journal-title":"Behav Brain Res"},{"key":"2020122903594562000_CIT0045","doi-asserted-by":"crossref","first-page":"13367","DOI":"10.1523\/JNEUROSCI.1437-13.2013","article-title":"Serotonin 2A receptors differentially contribute to abuse-related effects of cocaine and cocaine-induced nigrostriatal and mesolimbic dopamine overflow in nonhuman primates","volume":"33","author":"Murnane","year":"2013","journal-title":"J Neurosci"},{"key":"2020122903594562000_CIT0046","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1124\/jpet.118.250217","article-title":"5-HT2A Receptor agonist-induced hyperthermia is induced via vasoconstriction by peripheral 5-HT2A receptors and brown adipose tissue thermogenesis by peripheral serotonin loss at a high ambient temperature","volume":"367","author":"Nakamura","year":"2018","journal-title":"J Pharmacol Exp Ther"},{"key":"2020122903594562000_CIT0047","first-page":"1108","article-title":"Sodium-dependent isomerization of dopamine D-2 receptors characterized using [125I]epidepride, a high-affinity substituted benzamide ligand","volume":"252","author":"Neve","year":"1990","journal-title":"J Pharmacol Exp Ther"},{"key":"2020122903594562000_CIT0048","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s002130000397","article-title":"Risperidone counteracts lethality in an animal model of the serotonin syndrome","volume":"150","author":"Nisijima","year":"2000","journal-title":"Psychopharmacology (Berl)"},{"key":"2020122903594562000_CIT0049","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0006-8993(00)03020-1","article-title":"Potent serotonin (5-HT)(2A) receptor antagonists completely prevent the development of hyperthermia in an animal model of the 5-HT syndrome","volume":"890","author":"Nisijima","year":"2001","journal-title":"Brain Res"},{"key":"2020122903594562000_CIT0050","volume-title":"The rat brain in stereotaxic coordinates. 2nd ed","author":"Paxinos","year":"1986"},{"key":"2020122903594562000_CIT0051","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/BF03256574","article-title":"Cocaine cardiotoxicity: a review of the pathophysiology, pathology, and treatment options","volume":"9","author":"Phillips","year":"2009","journal-title":"Am J Cardiovasc Drugs"},{"key":"2020122903594562000_CIT0052","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s002130050454","article-title":"Extracellular dopamine, norepinephrine, and serotonin in the ventral tegmental area and nucleus accumbens of freely moving rats during intracerebral dialysis following systemic administration of cocaine and other uptake blockers","volume":"134","author":"Reith","year":"1997","journal-title":"Psychopharmacology (Berl)"},{"key":"2020122903594562000_CIT0053","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/0024-3205(90)90132-B","article-title":"Cocaine inhibition of ligand binding at dopamine, norepinephrine and serotonin transporters: a structure-activity study","volume":"46","author":"Ritz","year":"1990","journal-title":"Life Sci"},{"key":"2020122903594562000_CIT0054","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0091-3057(91)90337-2","article-title":"Dopamine receptors mediate cocaine-induced temperature responses in spontaneously hypertensive and Wistar-Kyoto rats","volume":"40","author":"Rockhold","year":"1991","journal-title":"Pharmacol Biochem Behav"},{"key":"2020122903594562000_CIT0055","first-page":"1361","article-title":"Binding of typical and atypical antipsychotic agents to transiently expressed 5-HT1C receptors","volume":"260","author":"Roth","year":"1992","journal-title":"J Pharmacol Exp Ther"},{"key":"2020122903594562000_CIT0056","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0014-2999(01)01188-8","article-title":"Ziprasidone: a novel antipsychotic agent with a unique human receptor binding profile","volume":"425","author":"Schmidt","year":"2001","journal-title":"Eur J Pharmacol"},{"key":"2020122903594562000_CIT0057","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/BF02245606","article-title":"Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding","volume":"124","author":"Schotte","year":"1996","journal-title":"Psychopharmacology (Berl)"},{"key":"2020122903594562000_CIT0058","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.drugalcdep.2018.07.043","article-title":"When DAWN went dark: can the Nationwide Emergency Department Sample (NEDS) fill the surveillance gap left by the discontinued Drug Abuse Warning Network (DAWN)?","volume":"192","author":"Sevigny","year":"2018","journal-title":"Drug Alcohol Depend"},{"key":"2020122903594562000_CIT0059","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1016\/j.neuro.2008.07.005","article-title":"Risperidone attenuates and reverses hyperthermia induced by 3,4-methylenedioxymethamphetamine (MDMA) in rats","volume":"29","author":"Shioda","year":"2008","journal-title":"Neurotoxicology"},{"key":"2020122903594562000_CIT0060","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.drugalcdep.2010.05.001","article-title":"Effect of risperidone on acute methamphetamine-induced hyperthermia in rats","volume":"111","author":"Shioda","year":"2010","journal-title":"Drug Alcohol Depend"},{"key":"2020122903594562000_CIT0061","first-page":"69","article-title":"Injection of SCH 23\u2005390 into the ventral tegmental area blocks the development of neurochemical but not behavioral sensitization to cocaine","volume":"9","author":"Steketee","year":"1998","journal-title":"Behav Pharmacol"},{"key":"2020122903594562000_CIT0062","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/0091-3057(95)02087-X","article-title":"Systemic and local cocaine increase extracellular serotonin in the nucleus accumbens","volume":"53","author":"Teneud","year":"1996","journal-title":"Pharmacol Biochem Behav"},{"key":"2020122903594562000_CIT0063","first-page":"440","article-title":"Standard binding and functional assays related to medications development division testing for potential cocaine and opiate narcotic treatment medications","volume":"178","author":"Toll","year":"1998","journal-title":"NIDA Res Monogr"},{"key":"2020122903594562000_CIT0068","year":"2019"},{"key":"2020122903594562000_CIT0064","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/PL00005133","article-title":"[3H]Rauwolscine: an antagonist radioligand for the cloned human 5-hydroxytryptamine2b (5-HT2B) receptor","volume":"357","author":"Wainscott","year":"1998","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"2020122903594562000_CIT0065","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/S0196-0644(05)81215-6","article-title":"Incidence of cocaine-associated rhabdomyolysis","volume":"20","author":"Welch","year":"1991","journal-title":"Ann Emerg Med"},{"key":"2020122903594562000_CIT0066","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0735-6757(96)90066-2","article-title":"Cocaine-associated agitated delirium and the neuroleptic malignant syndrome","volume":"14","author":"Wetli","year":"1996","journal-title":"Am J Emerg Med"},{"key":"2020122903594562000_CIT0067","doi-asserted-by":"crossref","first-page":"445","DOI":"10.2174\/187152706777950693","article-title":"Pharmacological profile of antipsychotics at monoamine receptors: atypicality beyond 5-HT2A receptor blockade","volume":"5","author":"Wood","year":"2006","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"2020122903594562000_CIT0069","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1254\/jjp.48.145","article-title":"The involvement of serotonergic and dopaminergic systems in hypothermia induced in mice by intracerebroventricular injection of serotonin","volume":"48","author":"Yamada","year":"1998","journal-title":"Jpn J Pharmacol"},{"key":"2020122903594562000_CIT0070","first-page":"383","article-title":"Dopaminergic and serotonergic mechanisms of thermoregulation: mediation of thermal effects of apomorphine and dopamine","volume":"227","author":"Yamawaki","year":"1983","journal-title":"J Pharmacol Exp Ther"},{"key":"2020122903594562000_CIT0071","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0361-9230(99)00208-7","article-title":"Activation of 5-HT2A\/2C receptors within the nucleus accumbens increases local dopaminergic transmission","volume":"51","author":"Yan","year":"2000","journal-title":"Brain Res Bull"},{"key":"2020122903594562000_CIT0072","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s00213-010-1996-3","article-title":"Blockade of nucleus accumbens 5-HT2A and 5-HT2C receptors prevents the expression of cocaine-induced behavioral and neurochemical sensitization in rats","volume":"213","author":"Zayara","year":"2011","journal-title":"Psychopharmacology (Berl)"},{"key":"2020122903594562000_CIT0073","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.ccc.2012.07.003","article-title":"Cocaine intoxication","volume":"28","author":"Zimmerman","year":"2012","journal-title":"Crit Care Clin"}],"container-title":["International Journal of Neuropsychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ijnp\/advance-article-pdf\/doi\/10.1093\/ijnp\/pyaa065\/33733179\/pyaa065.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/ijnp\/article-pdf\/23\/12\/811\/35175780\/pyaa065.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/ijnp\/article-pdf\/23\/12\/811\/35175780\/pyaa065.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,29]],"date-time":"2020-12-29T04:01:14Z","timestamp":1609214474000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ijnp\/article\/23\/12\/811\/5895280"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,21]]},"references-count":73,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,12,29]]}},"URL":"https:\/\/doi.org\/10.1093\/ijnp\/pyaa065","relation":{},"ISSN":["1461-1457","1469-5111"],"issn-type":[{"value":"1461-1457","type":"print"},{"value":"1469-5111","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,12,1]]},"published":{"date-parts":[[2020,8,21]]}}}