{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T03:21:47Z","timestamp":1772940107474,"version":"3.50.1"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2020,12,11]],"date-time":"2020-12-11T00:00:00Z","timestamp":1607644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001677","name":"Institute National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006319","name":"Centre National pour la Recherche Scientifique et Technique","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","award":["DPA20140629806"],"award-info":[{"award-number":["DPA20140629806"]}],"id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-15-CE37-0010"],"award-info":[{"award-number":["ANR-15-CE37-0010"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,7,14]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The chronic relapsing nature of cocaine addiction suggests that chronic cocaine exposure produces persistent neuroadaptations that may be temporally and regionally dynamic in brain areas such as the dopaminergic (DA) system. We have previously shown altered metabolism of DA-target structures, the ventral and dorsal striatum, between early and late abstinence. However, specific changes within the midbrain DA system were not investigated. Here, we investigated potential time- and region-specific changes of activity in the ventral tegmental area (VTA) and the substantia nigra pars compacta (SNc) in rats that had extended or limited access to cocaine and later underwent a period of abstinence. We found that DA activity is decreased only in the VTA in rats with extended access to cocaine, with no changes in SNc DA activity. These changes in VTA DA activity may participate in the negative emotional state and the incubation of drug seeking that occur during abstinence from cocaine.<\/jats:p>","DOI":"10.1093\/ijnp\/pyaa096","type":"journal-article","created":{"date-parts":[[2020,12,9]],"date-time":"2020-12-09T04:03:35Z","timestamp":1607486615000},"page":"499-504","source":"Crossref","is-referenced-by-count":6,"title":["Protracted Abstinence From Extended Cocaine Self-Administration Is Associated With Hypodopaminergic Activity in the VTA but Not in the SNc"],"prefix":"10.1093","volume":"24","author":[{"given":"Ad\u00e9lie","family":"Salin","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Poitiers, INSERM, Laboratoire de Neurosciences Exp\u00e9rimentales et Cliniques, Poitiers, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginie","family":"Lardeux","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Poitiers, INSERM, Laboratoire de Neurosciences Exp\u00e9rimentales et Cliniques, Poitiers, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcello","family":"Solinas","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Poitiers, INSERM, Laboratoire de Neurosciences Exp\u00e9rimentales et Cliniques, Poitiers, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pauline","family":"Belujon","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Poitiers, INSERM, Laboratoire de Neurosciences Exp\u00e9rimentales et Cliniques, Poitiers, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,12,11]]},"reference":[{"key":"2021071411321042400_CIT0001","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1126\/science.282.5387.298","article-title":"Transition from moderate to excessive drug intake: change in hedonic set 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