{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T01:27:11Z","timestamp":1788571631003,"version":"build-2803163510"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2021,4,2]],"date-time":"2021-04-02T00:00:00Z","timestamp":1617321600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DA040032"],"award-info":[{"award-number":["DA040032"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DA045743"],"award-info":[{"award-number":["DA045743"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DA044749"],"award-info":[{"award-number":["DA044749"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DA023248"],"award-info":[{"award-number":["DA023248"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,8,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Cocaine addiction is associated with altered sensitivity to natural reinforcers and intense drug craving. However, previous findings on reward-related responses were mixed, and few studies have examined whether reward responses relate to tonic cocaine craving.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We combined functional magnetic resonance imaging and a monetary incentive delay task to investigate these issues. Imaging data were processed with published routines, and the results were evaluated with a corrected threshold. We compared reward responses of 50 cocaine-dependent individuals (CDs) and 45 healthy controls (HCs) for the ventral striatum (VS) and the whole brain. We also examined the regional responses in association with tonic cocaine craving, as assessed by the Cocaine Craving Questionnaire (CCQ) in CDs. We performed mediation analyses to evaluate the relationship between regional responses, CCQ score, and recent cocaine use.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The VS showed higher activation to large as compared with small or no wins, but this reward-related activity did not differ between CDs and HCs. The precentral gyrus (PCG), anterior insula, and supplementary motor area showed higher activation during large vs no wins in positive correlation with the CCQ score in CDs. Mediation analyses suggested that days of cocaine use in the prior month contributed to higher CCQ scores and, in turn, PCG reward responses.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The results highlight a unique relationship between reward responses of the primary motor cortex, tonic cocaine craving, and recent cocaine use. The motor cortex may partake in the cognitive motor processes critical to drug-seeking behavior in addicted individuals.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ijnp\/pyab016","type":"journal-article","created":{"date-parts":[[2021,3,30]],"date-time":"2021-03-30T03:12:43Z","timestamp":1617073963000},"page":"634-644","source":"Crossref","is-referenced-by-count":8,"title":["Reward-Related Responses and Tonic Craving in Cocaine Addiction: An Imaging Study of the Monetary Incentive Delay Task"],"prefix":"10.1093","volume":"24","author":[{"given":"Simon","family":"Zhornitsky","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isha","family":"Dhingra","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4196-8646","authenticated-orcid":false,"given":"Thang M","family":"Le","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wuyi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9393-1212","authenticated-orcid":false,"given":"Chiang-shan R","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA"},{"name":"Department of Neuroscience, Yale University School of Medicine, New Haven, CT, USA"},{"name":"Interdepartmental Neuroscience Program, Yale University, New Haven, CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,4,2]]},"reference":[{"key":"2021082012002539700_CIT0001","volume-title":"Diagnostic and statistical manual of mental disorders-IV-TR","author":"APA","year":"2005"},{"key":"2021082012002539700_CIT0002","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1002\/(SICI)1097-0193(1999)7:4<254::AID-HBM4>3.0.CO;2-G","article-title":"Nonlinear spatial normalization using basis functions","volume":"7","author":"Ashburner","year":"1999","journal-title":"Hum Brain Mapp"},{"key":"2021082012002539700_CIT0003","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1038\/npp.2016.11","article-title":"Neurofunctional reward processing changes in cocaine dependence during recovery","volume":"41","author":"Balodis","year":"2016","journal-title":"Neuropsychopharmacology"},{"key":"2021082012002539700_CIT0004","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0006-3223(00)00948-3","article-title":"Elevated motor threshold in drug-free, cocaine-dependent patients assessed with transcranial magnetic stimulation","volume":"49","author":"Boutros","year":"2001","journal-title":"Biol Psychiatry"},{"key":"2021082012002539700_CIT0005","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1111\/adb.12041","article-title":"Abstinence duration modulates striatal functioning during monetary reward processing in cocaine patients","volume":"19","author":"Bustamante","year":"2014","journal-title":"Addict Biol"},{"key":"2021082012002539700_CIT0006","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/j.neuron.2011.02.027","article-title":"Model-based influences on humans\u2019 choices and striatal prediction errors","volume":"69","author":"Daw","year":"2011","journal-title":"Neuron"},{"key":"2021082012002539700_CIT0007","doi-asserted-by":"crossref","first-page":"116368","DOI":"10.1016\/j.neuroimage.2019.116368","article-title":"The effects of age on reward magnitude processing in the monetary incentive delay task","volume":"207","author":"Dhingra","year":"2019","journal-title":"Neuroimage"},{"key":"2021082012002539700_CIT0058","first-page":"12","article-title":"Sex differences in neural responses to reward and the influences of individual reward and punishment sensitivity. BMC Neurosci.","volume":"22","author":"Dhingra","year":"2021"},{"key":"2021082012002539700_CIT0008","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/bs.pbr.2015.10.002","article-title":"Neuroscience of drug craving for addiction medicine: from circuits to therapies","volume":"223","author":"Ekhtiari","year":"2016","journal-title":"Prog Brain Res"},{"key":"2021082012002539700_CIT0009","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1006\/nimg.1995.1007","article-title":"Analysis of fMRI time-series revisited","volume":"2","author":"Friston","year":"1995","journal-title":"Neuroimage"},{"key":"2021082012002539700_CIT0010","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1176\/appi.ajp.157.11.1789","article-title":"Cue-induced cocaine craving: neuroanatomical specificity for drug users and drug stimuli","volume":"157","author":"Garavan","year":"2000","journal-title":"Am J Psychiatry"},{"key":"2021082012002539700_CIT0011","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1002\/ana.410300308","article-title":"Alterations of dopaminergic and noradrenergic innervations in motor cortex in Parkinson\u2019s disease","volume":"30","author":"Gaspar","year":"1991","journal-title":"Ann Neurol"},{"key":"2021082012002539700_CIT0012","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1176\/ajp.2007.164.1.43","article-title":"Is decreased prefrontal cortical sensitivity to monetary reward associated with impaired motivation and self-control in cocaine addiction?","volume":"164","author":"Goldstein","year":"2007","journal-title":"Am J Psychiatry"},{"key":"2021082012002539700_CIT0013","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1177\/0269881108096982","article-title":"Liking and wanting of drug and non-drug rewards in active cocaine users: the STRAP-R questionnaire","volume":"24","author":"Goldstein","year":"2010","journal-title":"J Psychopharmacol"},{"key":"2021082012002539700_CIT0014","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.neuroimage.2010.06.066","article-title":"Mesocorticolimbic circuits are impaired in chronic cocaine users as demonstrated by resting-state functional connectivity","volume":"53","author":"Gu","year":"2010","journal-title":"Neuroimage"},{"key":"2021082012002539700_CIT0015","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.pscychresns.2009.07.009","article-title":"Loss of laterality in chronic cocaine users: an fMRI investigation of sensorimotor control","volume":"181","author":"Hanlon","year":"2010","journal-title":"Psychiatry Res"},{"key":"2021082012002539700_CIT0016","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.drugalcdep.2010.11.008","article-title":"The association between frontal-striatal connectivity and sensorimotor control in cocaine users","volume":"115","author":"Hanlon","year":"2011","journal-title":"Drug Alcohol Depend"},{"key":"2021082012002539700_CIT0017","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1097\/00008877-200002000-00010","article-title":"Alternative reinforcers differentially modify cocaine self-administration by humans","volume":"11","author":"Hart","year":"2000","journal-title":"Behav Pharmacol"},{"key":"2021082012002539700_CIT0018","first-page":"271","article-title":"Exploring neural correlates of different dimensions in drug craving self-reports among heroin dependents","volume":"6","author":"Hassani-Abharian","year":"2015","journal-title":"Basic Clin Neurosci"},{"key":"2021082012002539700_CIT0019","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0024-3205(94)00878-7","article-title":"Influence of an alternative reinforcer on human cocaine self-administration","volume":"55","author":"Higgins","year":"1994","journal-title":"Life Sci"},{"key":"2021082012002539700_CIT0020","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3389\/fneur.2013.00145","article-title":"Dopaminergic meso-cortical projections to m1: role in motor learning and motor cortex plasticity","volume":"4","author":"Hosp","year":"2013","journal-title":"Front Neurol"},{"key":"2021082012002539700_CIT0021","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1017\/S0033291713001839","article-title":"Altered social and non-social decision-making in recreational and dependent cocaine users","volume":"44","author":"Hulka","year":"2014","journal-title":"Psychol Med"},{"key":"2021082012002539700_CIT0022","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.biopsych.2011.05.008","article-title":"An initial study of neural responses to monetary incentives as related to treatment outcome in cocaine dependence","volume":"70","author":"Jia","year":"2011","journal-title":"Biol Psychiatry"},{"key":"2021082012002539700_CIT0023","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/s41398-019-0399-4","article-title":"Effects of familial risk and stimulant drug use on the anticipation of monetary reward: an fMRI study","volume":"9","author":"Just","year":"2019","journal-title":"Transl Psychiatry"},{"key":"2021082012002539700_CIT0024","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.pscychresns.2016.01.001","article-title":"Converging effects of cocaine addiction and sex on neural responses to monetary rewards","volume":"248","author":"Konova","year":"2016","journal-title":"Psychiatry Res Neuroimaging"},{"key":"2021082012002539700_CIT0025","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1177\/1745691612457575","article-title":"Motivation and self-regulation in addiction: a call for convergence","volume":"8","author":"K\u00f6petz","year":"2013","journal-title":"Perspect Psychol Sci"},{"key":"2021082012002539700_CIT0026","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1038\/sj.npp.1300851","article-title":"Cue-induced brain activity changes and relapse in cocaine-dependent patients","volume":"31","author":"Kosten","year":"2006","journal-title":"Neuropsychopharmacology"},{"key":"2021082012002539700_CIT0027","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1111\/j.1460-9568.2010.07590.x","article-title":"Common biology of craving across legal and illegal drugs - a quantitative meta-analysis of cue-reactivity brain response","volume":"33","author":"Kuhn","year":"2011","journal-title":"Eur J Neurosci"},{"key":"2021082012002539700_CIT0028","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.drugalcdep.2016.12.008","article-title":"The effect of task difficulty on motor performance and frontal-striatal connectivity in cocaine users","volume":"173","author":"Lench","year":"2017","journal-title":"Drug Alcohol Depend"},{"key":"2021082012002539700_CIT0029","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1002\/(SICI)1522-2594(200001)43:1<45::AID-MRM6>3.0.CO;2-0","article-title":"Cocaine administration decreases functional connectivity in human primary visual and motor cortex as detected by functional MRI","volume":"43","author":"Li","year":"2000","journal-title":"Magn Reson Med"},{"key":"2021082012002539700_CIT0030","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.tics.2012.07.007","article-title":"Contributions of the striatum to learning, motivation, and performance: an associative account","volume":"16","author":"Liljeholm","year":"2012","journal-title":"Trends Cogn Sci"},{"key":"2021082012002539700_CIT0031","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1001\/jamapsychiatry.2016.3084","article-title":"Disruption of reward processing in addiction: an image-based meta-analysis of functional magnetic resonance imaging studies","volume":"74","author":"Luijten","year":"2017","journal-title":"JAMA Psychiatry"},{"key":"2021082012002539700_CIT0032","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1146\/annurev.psych.58.110405.085542","article-title":"Mediation analysis","volume":"58","author":"MacKinnon","year":"2007","journal-title":"Annu Rev Psychol"},{"key":"2021082012002539700_CIT0033","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.drugalcdep.2017.12.015","article-title":"Psychosocial and neural indicators of resilience among youth with a family history of substance use disorder","volume":"185","author":"Martz","year":"2018","journal-title":"Drug Alcohol Depend"},{"key":"2021082012002539700_CIT0034","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.tins.2008.09.009","article-title":"The hidden island of addiction: the insula","volume":"32","author":"Naqvi","year":"2009","journal-title":"Trends Neurosci"},{"key":"2021082012002539700_CIT0035","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1126\/science.1135926","article-title":"Damage to the insula disrupts addiction to cigarette smoking","volume":"315","author":"Naqvi","year":"2007","journal-title":"Science"},{"key":"2021082012002539700_CIT0036","doi-asserted-by":"crossref","first-page":"3398","DOI":"10.1002\/hbm.24184","article-title":"The anticipation and outcome phases of reward and loss processing: a neuroimaging meta-analysis of the monetary incentive delay task","volume":"39","author":"Oldham","year":"2018","journal-title":"Hum Brain Mapp"},{"key":"2021082012002539700_CIT0037","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.biopsych.2013.04.029","article-title":"Robust changes in reward circuitry during reward loss in current and former cocaine users during performance of a monetary incentive delay task","volume":"74","author":"Patel","year":"2013","journal-title":"Biol Psychiatry"},{"key":"2021082012002539700_CIT0038","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1002\/cne.23937","article-title":"Human-specific increase of dopaminergic innervation in a striatal region associated with speech and language: a comparative analysis of the primate basal ganglia","volume":"524","author":"Raghanti","year":"2016","journal-title":"J Comp Neurol"},{"key":"2021082012002539700_CIT0039","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1038\/npp.2016.161","article-title":"Dissociable effects of cocaine dependence on reward processes: the role of acute cocaine and craving","volume":"42","author":"Rose","year":"2017","journal-title":"Neuropsychopharmacology"},{"key":"2021082012002539700_CIT0040","doi-asserted-by":"crossref","first-page":"e0167400","DOI":"10.1371\/journal.pone.0167400","article-title":"Reward contingencies improve goal-directed behavior by enhancing posterior brain attentional regions and increasing corticostriatal connectivity in cocaine addicts","volume":"11","author":"Rosell-Negre","year":"2016","journal-title":"PLoS One"},{"key":"2021082012002539700_CIT0041","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1007\/s00213-005-0080-x","article-title":"Severity of nicotine dependence modulates cue-induced brain activity in regions involved in motor preparation and imagery","volume":"184","author":"Smolka","year":"2006","journal-title":"Psychopharmacology"},{"key":"2021082012002539700_CIT0042","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.drugalcdep.2005.11.022","article-title":"The validity and reliability of a brief measure of cocaine craving","volume":"83","author":"Sussner","year":"2006","journal-title":"Drug Alcohol Depend"},{"key":"2021082012002539700_CIT0043","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1093\/scan\/nsw030","article-title":"Shared neural basis of social and non-social reward deficits in chronic cocaine users","volume":"11","author":"Tobler","year":"2016","journal-title":"Soc Cogn Affect Neurosci"},{"key":"2021082012002539700_CIT0044","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.drugalcdep.2009.02.003","article-title":"Decision-making in long-term cocaine users: effects of a cash monetary contingency on gambling task performance","volume":"102","author":"Vadhan","year":"2009","journal-title":"Drug Alcohol Depend"},{"key":"2021082012002539700_CIT0045","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3389\/fncir.2014.00013","article-title":"Dopamine control of pyramidal neuron activity in the primary motor cortex via D2 receptors","volume":"8","author":"Vitrac","year":"2014","journal-title":"Front Neural Circuits"},{"key":"2021082012002539700_CIT0046","doi-asserted-by":"crossref","first-page":"6583","DOI":"10.1523\/JNEUROSCI.1544-06.2006","article-title":"Cocaine cues and dopamine in dorsal striatum: mechanism of craving in cocaine addiction","volume":"26","author":"Volkow","year":"2006","journal-title":"J Neurosci"},{"key":"2021082012002539700_CIT0047","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.drugalcdep.2010.02.015","article-title":"Using a novel alternative to drug choice in a human laboratory model of a cocaine binge: a game of chance","volume":"110","author":"Vosburg","year":"2010","journal-title":"Drug Alcohol Depend"},{"key":"2021082012002539700_CIT0048","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.neuron.2008.09.006","article-title":"Prefrontal-subcortical pathways mediating successful emotion regulation","volume":"59","author":"Wager","year":"2008","journal-title":"Neuron"},{"key":"2021082012002539700_CIT0049","doi-asserted-by":"crossref","first-page":"189853","DOI":"10.1155\/2014\/189853","article-title":"Choosing money over drugs: the neural underpinnings of difficult choice in chronic cocaine users","volume":"2014","author":"Wesley","year":"2014","journal-title":"J Addict"},{"key":"2021082012002539700_CIT0050","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1093\/cercor\/3.3.199","article-title":"Characterization of the dopaminergic innervation of the primate frontal-cortex using a dopamine-specific antibody","volume":"3","author":"Williams","year":"1993","journal-title":"Cereb Cortex"},{"key":"2021082012002539700_CIT0051","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.neubiorev.2011.12.004","article-title":"Functional neuroimaging studies in addiction: multisensory drug stimuli and neural cue reactivity","volume":"36","author":"Yalachkov","year":"2012","journal-title":"Neurosci Biobehav Rev"},{"key":"2021082012002539700_CIT0052","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/j.neuroimage.2008.05.055","article-title":"Stereotaxic probabilistic maps of the magnocellular cell groups in human basal forebrain","volume":"42","author":"Zaborszky","year":"2008","journal-title":"Neuroimage"},{"key":"2021082012002539700_CIT0053","doi-asserted-by":"crossref","first-page":"2573","DOI":"10.1007\/s00429-016-1358-y","article-title":"Hemispheric lateralization of resting-state functional connectivity of the ventral striatum: an exploratory study","volume":"222","author":"Zhang","year":"2017","journal-title":"Brain Struct Funct"},{"key":"2021082012002539700_CIT0054","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/s41398-018-0164-0","article-title":"Ventral striatal dysfunction in cocaine dependence - difference mapping for subregional resting state functional connectivity","volume":"8","author":"Zhang","year":"2018","journal-title":"Transl Psychiatry"},{"key":"2021082012002539700_CIT0055","doi-asserted-by":"crossref","first-page":"e12682","DOI":"10.1111\/adb.12682","article-title":"Hypothalamic response to cocaine cues and cocaine addiction severity","volume":"25","author":"Zhang","year":"2020","journal-title":"Addict Biol"},{"key":"2021082012002539700_CIT0056","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1093\/ijnp\/pyz044","article-title":"Hypothalamic responses to cocaine and food cues in individuals with cocaine dependence","volume":"22","author":"Zhang","year":"2019","journal-title":"Int J Neuropsychopharmacol"},{"key":"2021082012002539700_CIT0057","doi-asserted-by":"crossref","first-page":"108240","DOI":"10.1016\/j.drugalcdep.2020.108240","article-title":"Cue-elicited functional connectivity of the periaqueductal gray and tonic cocaine craving","volume":"216","author":"Zhang","year":"2020","journal-title":"Drug Alcohol Depend"}],"container-title":["International Journal of Neuropsychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ijnp\/advance-article-pdf\/doi\/10.1093\/ijnp\/pyab016\/37895911\/pyab016.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/ijnp\/article-pdf\/24\/8\/634\/39819700\/pyab016.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/ijnp\/article-pdf\/24\/8\/634\/39819700\/pyab016.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,20]],"date-time":"2021-08-20T12:01:38Z","timestamp":1629460898000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ijnp\/article\/24\/8\/634\/6208276"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,2]]},"references-count":58,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2021,4,2]]},"published-print":{"date-parts":[[2021,8,20]]}},"URL":"https:\/\/doi.org\/10.1093\/ijnp\/pyab016","relation":{},"ISSN":["1461-1457","1469-5111"],"issn-type":[{"value":"1461-1457","type":"print"},{"value":"1469-5111","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,8,1]]},"published":{"date-parts":[[2021,4,2]]}}}