{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T09:56:16Z","timestamp":1790502976836,"version":"4.1.0"},"reference-count":81,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T00:00:00Z","timestamp":1623196800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["290019\/2017-6"],"award-info":[{"award-number":["290019\/2017-6"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["316803389"],"award-info":[{"award-number":["316803389"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["BMBF - GCBS 01EE1501"],"award-info":[{"award-number":["BMBF - GCBS 01EE1501"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["TRAINSTIM 01GQ1424E"],"award-info":[{"award-number":["TRAINSTIM 01GQ1424E"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,10,23]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The serotonergic system has an important impact on basic physiological and higher brain functions. Acute and chronic enhancement of serotonin levels via selective serotonin reuptake inhibitor administration impacts neuroplasticity in humans, as shown by its effects on cortical excitability alterations induced by non-invasive brain stimulation, including transcranial direct current stimulation (tDCS). Nevertheless, the interaction between serotonin activation and neuroplasticity is not fully understood, particularly considering dose-dependent effects. Our goal was to explore dosage-dependent effects of acute serotonin enhancement on stimulation-induced plasticity in healthy individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twelve healthy adults participated in 7 sessions conducted in a crossover, partially double-blinded, randomized, and sham-controlled study design. Anodal and cathodal tDCS was applied to the motor cortex under selective serotonin reuptake inhibitor (20 mg\/40 mg citalopram) or placebo medication. Motor cortex excitability was monitored by single-pulse transcranial magnetic stimulation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Under placebo medication, anodal tDCS enhanced, and cathodal tDCS reduced, excitability for approximately 60\u2013120 minutes after the intervention. Citalopram enhanced and prolonged the facilitation induced by anodal tDCS regardless of the dosage while turning cathodal tDCS-induced excitability diminution into facilitation. For the latter, prolonged effects were observed when 40 mg was administrated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Acute serotonin enhancement modulates tDCS after-effects and has largely similar modulatory effects on motor cortex neuroplasticity regardless of the specific dosage. A minor dosage-dependent effect was observed only for cathodal tDCS. The present findings support the concept of boosting the neuroplastic effects of anodal tDCS by serotonergic enhancement, a potential clinical approach for the treatment of neurological and psychiatric disorders.<\/jats:p><\/jats:sec>","DOI":"10.1093\/ijnp\/pyab035","type":"journal-article","created":{"date-parts":[[2021,6,7]],"date-time":"2021-06-07T19:47:19Z","timestamp":1623095239000},"page":"787-797","source":"Crossref","is-referenced-by-count":23,"title":["Dosage-Dependent Impact of Acute Serotonin Enhancement on Transcranial Direct Current Stimulation Effects"],"prefix":"10.1093","volume":"24","author":[{"given":"Lorena","family":"Melo","sequence":"first","affiliation":[{"name":"Department of Psychology and Neurosciences, Leibniz Research Centre for Working Environment and Human Factors (IfADo), Dortmund, Germany"},{"name":"International Graduate School of Neuroscience (IGSN), Ruhr-University Bochum, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohsen","family":"Mosayebi-Samani","sequence":"additional","affiliation":[{"name":"Department of Psychology and Neurosciences, Leibniz Research Centre for Working Environment and Human Factors (IfADo), Dortmund, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elham","family":"Ghanavati","sequence":"additional","affiliation":[{"name":"Department of Psychology and Neurosciences, Leibniz Research Centre for Working Environment and Human Factors (IfADo), Dortmund, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A","family":"Nitsche","sequence":"additional","affiliation":[{"name":"Department of Psychology and Neurosciences, Leibniz Research Centre for Working Environment and Human Factors (IfADo), Dortmund, Germany"},{"name":"Department of Neurology, University Medical Hospital Bergmannsheil, Bochum, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Fang","family":"Kuo","sequence":"additional","affiliation":[{"name":"Department of Psychology and Neurosciences, Leibniz Research Centre for Working Environment and Human Factors (IfADo), Dortmund, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,6,9]]},"reference":[{"key":"2021102310543528700_CIT0001","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1007\/s00115-016-0115-z","article-title":"[Non-invasive brain stimulation in neurology: transcranial direct current stimulation to enhance cognitive functioning]","volume":"87","author":"Antonenko","year":"2016","journal-title":"Nervenarzt"},{"key":"2021102310543528700_CIT0002","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/S0028-3908(99)00010-6","article-title":"A review of central 5-HT receptors and their function","volume":"38","author":"Barnes","year":"1999","journal-title":"Neuropharmacology"},{"key":"2021102310543528700_CIT0003","doi-asserted-by":"crossref","first-page":"2260","DOI":"10.1038\/npp.2013.127","article-title":"Effect of serotonin on paired associative stimulation-induced plasticity in the human motor cortex","volume":"38","author":"Batsikadze","year":"2013","journal-title":"Neuropsychopharmacology"},{"key":"2021102310543528700_CIT0004","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1113\/jphysiol.2012.249730","article-title":"Partially non-linear stimulation intensity-dependent effects of direct current stimulation on motor cortex excitability in humans","volume":"591","author":"Batsikadze","year":"2013","journal-title":"J Physiol"},{"key":"2021102310543528700_CIT0005","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.bbr.2008.02.028","article-title":"Learning and memory in 5-HT(1A)-receptor mutant mice","volume":"195","author":"Bert","year":"2008","journal-title":"Behav Brain Res"},{"key":"2021102310543528700_CIT0006","first-page":"241","article-title":"Citalopram\u2013a review of pharmacological and clinical effects","volume":"25","author":"Bezchlibnyk-Butler","year":"2000","journal-title":"J Psychiatry Neurosci"},{"key":"2021102310543528700_CIT0007","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1017\/S1461145710001690","article-title":"A systematic review on reporting and assessment of adverse effects associated with transcranial direct current stimulation","volume":"14","author":"Brunoni","year":"2011","journal-title":"Int J Neuropsychopharmacol"},{"key":"2021102310543528700_CIT0008","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1001\/2013.jamapsychiatry.32","article-title":"The sertraline vs. electrical current therapy for treating depression clinical study: results from a factorial, randomized, controlled trial","volume":"70","author":"Brunoni","year":"2013","journal-title":"JAMA Psychiatry"},{"key":"2021102310543528700_CIT0009","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1113\/jphysiol.2001.013391","article-title":"Activity-dependent bidirectional regulation of GABA(A) receptor channels by the 5-HT(4) receptor-mediated signalling in rat prefrontal cortical pyramidal neurons","volume":"540","author":"Cai","year":"2002","journal-title":"J Physiol"},{"key":"2021102310543528700_CIT0010","doi-asserted-by":"crossref","first-page":"5346","DOI":"10.1093\/cercor\/bhaa116","article-title":"Nonlinear effects of dopamine D1 receptor activation on visuomotor coordination task performance","volume":"30","author":"Chen","year":"2020","journal-title":"Cereb Cortex"},{"key":"2021102310543528700_CIT0011","doi-asserted-by":"crossref","first-page":"101","DOI":"10.2174\/157015906776359540","article-title":"Serotonin as a modulator of glutamate- and GABA-mediated neurotransmission: implications in physiological functions and in pathology","volume":"4","author":"Ciranna","year":"2006","journal-title":"Curr Neuropharmacol"},{"key":"2021102310543528700_CIT0012","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/S0896-6273(00)80102-6","article-title":"Ca2+ signaling requirements for long-term depression in the hippocampus","volume":"16","author":"Cummings","year":"1996","journal-title":"Neuron"},{"key":"2021102310543528700_CIT0013","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1177\/0269881114543719","article-title":"Vortioxetine disinhibits pyramidal cell function and enhances synaptic plasticity in the rat hippocampus","volume":"28","author":"Dale","year":"2014","journal-title":"J Psychopharmacol"},{"key":"2021102310543528700_CIT0014","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.1113\/JP275440","article-title":"5-HT2A receptor activation enhances NMDA receptor-mediated glutamate responses through Src kinase in the dendrites of rat jaw-closing motoneurons","volume":"597","author":"Dantsuji","year":"2019","journal-title":"J Physiol"},{"key":"2021102310543528700_CIT0015","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.brs.2018.10.014","article-title":"Effects of electrode angle-orientation on the impact of transcranial direct current stimulation on motor cortex excitability","volume":"12","author":"Foerster","year":"2019","journal-title":"Brain Stimul"},{"key":"2021102310543528700_CIT0016","doi-asserted-by":"crossref","first-page":"2744","DOI":"10.1523\/JNEUROSCI.3655-13.2014","article-title":"Nonlinear dose-dependent impact of D1 receptor activation on motor cortex plasticity in humans","volume":"34","author":"Fresnoza","year":"2014","journal-title":"J Neurosci"},{"key":"2021102310543528700_CIT0017","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.neuron.2010.03.035","article-title":"Direct current stimulation promotes BDNF-dependent synaptic plasticity: potential implications for motor learning","volume":"66","author":"Fritsch","year":"2010","journal-title":"Neuron"},{"key":"2021102310543528700_CIT0018","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.biopsych.2007.05.033","article-title":"Imbalance between left and right dorsolateral prefrontal cortex in major depression is linked to negative emotional judgment: an fMRI study in severe major depressive disorder","volume":"63","author":"Grimm","year":"2008","journal-title":"Biol Psychiatry"},{"key":"2021102310543528700_CIT0019","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/S0306-4522(02)00026-X","article-title":"Neuromodulatory transmitter systems in the cortex and their role in cortical plasticity","volume":"111","author":"Gu","year":"2002","journal-title":"Neuroscience"},{"key":"2021102310543528700_CIT0020","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.nlm.2016.06.014","article-title":"The serotonergic 5-HT4 receptor: a unique modulator of hippocampal synaptic information processing and cognition","volume":"138","author":"Hagena","year":"2017","journal-title":"Neurobiol Learn Mem"},{"key":"2021102310543528700_CIT0021","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/j.brs.2020.02.027","article-title":"Determination of anodal tDCS duration threshold for reversal of corticospinal excitability: an investigation for induction of counter-regulatory mechanisms","volume":"13","author":"Hassanzahraee","year":"2020","journal-title":"Brain Stimul"},{"key":"2021102310543528700_CIT0022","doi-asserted-by":"crossref","first-page":"20111","DOI":"10.1038\/s41598-020-77111-0","article-title":"Transcranial direct current stimulation (tDCS) over the auditory cortex modulates GABA and glutamate: a 7 T MR-spectroscopy study","volume":"10","author":"Heimrath","year":"2020","journal-title":"Sci Rep"},{"key":"2021102310543528700_CIT0023","doi-asserted-by":"crossref","first-page":"3111","DOI":"10.1523\/JNEUROSCI.3908-06.2007","article-title":"5-Hydroxytryptamine induces a protein kinase A\/mitogen-activated protein kinase-mediated and macromolecular synthesis-dependent late phase of long-term potentiation in the amygdala","volume":"27","author":"Huang","year":"2007","journal-title":"J Neurosci"},{"key":"2021102310543528700_CIT0024","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1016\/j.brs.2019.06.003","article-title":"Effects of 6-month at-home transcranial direct current stimulation on cognition and cerebral glucose metabolism in Alzheimer\u2019s disease","volume":"12","author":"Im","year":"2019","journal-title":"Brain Stimul"},{"key":"2021102310543528700_CIT0025","doi-asserted-by":"crossref","first-page":"523","DOI":"10.4196\/kjpp.2015.19.6.523","article-title":"Enhancement of GluN2B subunit-containing NMDA receptor underlies serotonergic regulation of long-term potentiation after critical period in the rat visual cortex","volume":"19","author":"Joo","year":"2015","journal-title":"Korean J Physiol Pharmacol"},{"key":"2021102310543528700_CIT0026","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1093\/cercor\/bhh204","article-title":"The 5-hydroxytryptamine4 receptor exhibits frequency-dependent properties in synaptic plasticity and behavioural metaplasticity in the hippocampal CA1 region in vivo","volume":"15","author":"Kemp","year":"2005","journal-title":"Cereb Cortex"},{"key":"2021102310543528700_CIT0027","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/0006-8993(89)90126-1","article-title":"Increased population spike amplitude in the dentate gyrus following systemic administration of 5-hydroxytryptophan or 8-hydroxy-2-(di-n-propylamino)tetralin","volume":"505","author":"Klancnik","year":"1989","journal-title":"Brain Res"},{"key":"2021102310543528700_CIT0028","doi-asserted-by":"crossref","first-page":"S225","DOI":"10.1044\/1092-4388(2008\/018)","article-title":"Principles of experience-dependent neural plasticity: implications for rehabilitation after brain damage","volume":"51","author":"Kleim","year":"2008","journal-title":"J Speech Lang Hear Res"},{"key":"2021102310543528700_CIT0029","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0165-3806(97)00083-7","article-title":"Serotonin facilitates synaptic plasticity in kitten visual cortex: an in vitro study","volume":"101","author":"Kojic","year":"1997","journal-title":"Brain Res Dev Brain Res"},{"key":"2021102310543528700_CIT0030","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.neubiorev.2017.03.007","article-title":"Serotonin and neuroplasticity - links between molecular, functional and structural pathophysiology in depression","volume":"77","author":"Kraus","year":"2017","journal-title":"Neurosci Biobehav Rev"},{"key":"2021102310543528700_CIT0031","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.brs.2016.10.001","article-title":"Direct current stimulation modulates LTP and LTD: activity dependence and dendritic effects","volume":"10","author":"Kronberg","year":"2017","journal-title":"Brain Stimul"},{"key":"2021102310543528700_CIT0032","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1038\/npp.2015.270","article-title":"Chronic enhancement of serotonin facilitates excitatory transcranial direct current stimulation-induced neuroplasticity","volume":"41","author":"Kuo","year":"2016","journal-title":"Neuropsychopharmacology"},{"key":"2021102310543528700_CIT0033","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1042\/BST0371369","article-title":"Regulation of NMDA receptor Ca2+ signalling and synaptic plasticity","volume":"37","author":"Lau","year":"2009","journal-title":"Biochem Soc Trans"},{"key":"2021102310543528700_CIT0034","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.clinph.2016.10.087","article-title":"Evidence-based guidelines on the therapeutic use of transcranial direct current stimulation (tDCS)","volume":"128","author":"Lefaucheur","year":"2017","journal-title":"Clin Neurophysiol"},{"key":"2021102310543528700_CIT0035","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.1093\/brain\/awf238","article-title":"Pharmacological approach to the mechanisms of transcranial DC-stimulation-induced after-effects of human motor cortex excitability","volume":"125","author":"Liebetanz","year":"2002","journal-title":"Brain"},{"key":"2021102310543528700_CIT0036","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.brs.2018.10.002","article-title":"Transcranial direct-current stimulation in ultra-treatment-resistant schizophrenia","volume":"12","author":"Lindenmayer","year":"2019","journal-title":"Brain Stimul"},{"key":"2021102310543528700_CIT0037","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/j.1469-7793.2001.0285f.x","article-title":"Three Ca2+ levels affect plasticity differently: the LTP zone, the LTD zone and no man\u2019s land","volume":"532","author":"Lisman","year":"2001","journal-title":"J Physiol"},{"key":"2021102310543528700_CIT0038","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1093\/cercor\/bhr220","article-title":"5-HT1A receptor agonists enhance pyramidal cell firing in prefrontal cortex through a preferential action on GABA interneurons","volume":"22","author":"Llado-Pelfort","year":"2012","journal-title":"Cereb Cortex"},{"key":"2021102310543528700_CIT0039","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1097\/00004647-199912000-00010","article-title":"Cerebral functional magnetic resonance imaging activation modulated by a single dose of the monoamine neurotransmission enhancers fluoxetine and fenozolone during hand sensorimotor tasks","volume":"19","author":"Loubinoux","year":"1999","journal-title":"J Cereb Blood Flow Metab"},{"key":"2021102310543528700_CIT0040","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1016\/S0028-3932(02)00030-1","article-title":"Selective serotonin reuptake inhibitor paroxetine modulates motor behavior through practice. A double-blind, placebo-controlled, multi-dose study in healthy subjects","volume":"40","author":"Loubinoux","year":"2002","journal-title":"Neuropsychologia"},{"key":"2021102310543528700_CIT0041","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1006\/nimg.2001.0957","article-title":"A single dose of the serotonin neurotransmission agonist paroxetine enhances motor output: double-blind, placebo-controlled, fMRI study in healthy subjects","volume":"15","author":"Loubinoux","year":"2002","journal-title":"Neuroimage"},{"key":"2021102310543528700_CIT0042","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.neuroimage.2004.12.023","article-title":"Modulation of behavior and cortical motor activity in healthy subjects by a chronic administration of a serotonin enhancer","volume":"27","author":"Loubinoux","year":"2005","journal-title":"Neuroimage"},{"key":"2021102310543528700_CIT0043","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.neuron.2007.07.041","article-title":"Serotonin(4) (5-HT(4)) receptor agonists are putative antidepressants with a rapid onset of action","volume":"55","author":"Lucas","year":"2007","journal-title":"Neuron"},{"key":"2021102310543528700_CIT0044","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.neuron.2004.09.012","article-title":"LTP and LTD: an embarrassment of riches","volume":"44","author":"Malenka","year":"2004","journal-title":"Neuron"},{"key":"2021102310543528700_CIT0045","doi-asserted-by":"crossref","first-page":"99S","DOI":"10.1016\/S0893-133X(99)00040-8","article-title":"Role of the serotonergic system in the pathogenesis of major depression and suicidal behavior","volume":"21","author":"Mann","year":"1999","journal-title":"Neuropsychopharmacology"},{"key":"2021102310543528700_CIT0046","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.bbr.2019.01.023","article-title":"AMPA receptors are involved in prefrontal direct current stimulation effects on long-term working memory and GAP-43 expression","volume":"362","author":"Martins","year":"2019","journal-title":"Behav Brain Res"},{"key":"2021102310543528700_CIT0047","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/j.jalz.2014.07.159","article-title":"Transcranial direct current stimulation in mild cognitive impairment: behavioral effects and neural mechanisms","volume":"11","author":"Meinzer","year":"2015","journal-title":"Alzheimers Dement"},{"key":"2021102310543528700_CIT0048","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1007\/s00213-014-3693-0","article-title":"5-HT7 receptor activation: procognitive and antiamnesic effects","volume":"232","author":"Meneses","year":"2015","journal-title":"Psychopharmacology"},{"key":"2021102310543528700_CIT0049","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.neubiorev.2015.07.012","article-title":"Transcranial direct current stimulation (tDCS) in the treatment of depression: systematic review and meta-analysis of efficacy and tolerability","volume":"57","author":"Meron","year":"2015","journal-title":"Neurosci Biobehav Rev"},{"key":"2021102310543528700_CIT0050","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.brs.2012.04.011","article-title":"Induction of late LTP-like plasticity in the human motor cortex by repeated non-invasive brain stimulation","volume":"6","author":"Monte-Silva","year":"2013","journal-title":"Brain Stimul"},{"key":"2021102310543528700_CIT0051","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/S0091-3057(01)00546-9","article-title":"Different effects of anxiolytic agents, diazepam and 5-HT(1A) agonist tandospirone, on hippocampal long-term potentiation in vivo","volume":"69","author":"Mori","year":"2001","journal-title":"Pharmacol Biochem Behav"},{"key":"2021102310543528700_CIT0052","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.cortex.2019.04.016","article-title":"Titrating the neuroplastic effects of cathodal transcranial direct current stimulation (tDCS) over the primary motor cortex","volume":"119","author":"Mosayebi Samani","year":"2019","journal-title":"Cortex"},{"key":"2021102310543528700_CIT0053","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.euroneuro.2020.07.011","article-title":"Ca2+ channel dynamics explain the nonlinear neuroplasticity induction by cathodal transcranial direct current stimulation over the primary motor cortex","volume":"38","author":"Mosayebi-Samani","year":"2020","journal-title":"Eur Neuropsychopharmacol"},{"key":"2021102310543528700_CIT0054","first-page":"50:2722\u20132730.","article-title":"A role for 5-HT4 receptors in human learning and memory","author":"Murphy","year":"2019","journal-title":"Psychol Med"},{"key":"2021102310543528700_CIT0055","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1111\/j.1469-7793.2000.t01-1-00633.x","article-title":"Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation","volume":"527 Pt 3","author":"Nitsche","year":"2000","journal-title":"J Physiol"},{"key":"2021102310543528700_CIT0056","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1212\/WNL.57.10.1899","article-title":"Sustained excitability elevations induced by transcranial DC motor cortex stimulation in humans","volume":"57","author":"Nitsche","year":"2001","journal-title":"Neurology"},{"key":"2021102310543528700_CIT0057","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S1567-424X(09)70230-2","article-title":"Modulation of cortical excitability by weak direct current stimulation\u2013technical, safety and functional aspects","volume":"56","author":"Nitsche","year":"2003","journal-title":"Suppl Clin Neurophysiol"},{"key":"2021102310543528700_CIT0058","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1113\/jphysiol.2003.049916","article-title":"Pharmacological modulation of cortical excitability shifts induced by transcranial direct current stimulation in humans","volume":"553","author":"Nitsche","year":"2003","journal-title":"J Physiol"},{"key":"2021102310543528700_CIT0059","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1038\/sj.npp.1300517","article-title":"Consolidation of human motor cortical neuroplasticity by D-cycloserine","volume":"29","author":"Nitsche","year":"2004","journal-title":"Neuropsychopharmacology"},{"key":"2021102310543528700_CIT0060","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.brs.2008.06.004","article-title":"Transcranial direct current stimulation: state of the art 2008","volume":"1","author":"Nitsche","year":"2008","journal-title":"Brain Stimul"},{"key":"2021102310543528700_CIT0061","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.biopsych.2009.03.022","article-title":"Serotonin affects transcranial direct current-induced neuroplasticity in humans","volume":"66","author":"Nitsche","year":"2009","journal-title":"Biol Psychiatry"},{"key":"2021102310543528700_CIT0062","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1002\/da.22738","article-title":"Impaired neuroplasticity in the prefrontal cortex in depression indexed through paired associative stimulation","volume":"35","author":"Noda","year":"2018","journal-title":"Depress Anxiety"},{"key":"2021102310543528700_CIT0063","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.biopsych.2006.10.006","article-title":"Long-term plasticity of visually evoked potentials in humans is altered in major depression","volume":"62","author":"Normann","year":"2007","journal-title":"Biol Psychiatry"},{"key":"2021102310543528700_CIT0064","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.bbr.2008.02.023","article-title":"The role of 5-HT(1A) receptors in learning and memory","volume":"195","author":"Ogren","year":"2008","journal-title":"Behav Brain Res"},{"key":"2021102310543528700_CIT0065","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0006-8993(02)02973-6","article-title":"Changes in synaptic plasticity in the rat hippocampo-medial prefrontal cortex pathway induced by repeated treatments with fluvoxamine","volume":"949","author":"Ohashi","year":"2002","journal-title":"Brain Res"},{"key":"2021102310543528700_CIT0066","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0028-3932(71)90067-4","article-title":"The assessment and analysis of handedness: The Edinburgh Inventory","volume":"9","author":"Oldfield","year":"1971","journal-title":"Neuropsychologia"},{"key":"2021102310543528700_CIT0067","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/s00221-013-3594-1","article-title":"High dose of 8-OH-DPAT decreases maximal dentate gyrus activation and facilitates granular cell plasticity in vivo","volume":"230","author":"Orban","year":"2013","journal-title":"Exp Brain Res"},{"key":"2021102310543528700_CIT0068","article-title":"Prefrontal transcranial direct current stimulation (tDCS) as treatment for major depression: study design and methodology of a multicenter triple blind randomized placebo controlled trial (DepressionDC)","author":"Padberg","year":"2017","journal-title":"Eur Arch Psychiatry Clin Neurosci 267:751\u2013766. doi:10.1007\/s00406-017-0769-y"},{"key":"2021102310543528700_CIT0069","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1080\/13554794.2017.1319492","article-title":"Prefrontal tDCS and sertraline in obsessive compulsive disorder: a case report and review of the literature","volume":"23","author":"Palm","year":"2017","journal-title":"Neurocase"},{"key":"2021102310543528700_CIT0070","doi-asserted-by":"crossref","first-page":"2560","DOI":"10.1073\/pnas.88.6.2560","article-title":"Receptors of the serotonin 1C subtype expressed from cloned DNA mediate the closing of K+ membrane channels encoded by brain mRNA","volume":"88","author":"Panicker","year":"1991","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2021102310543528700_CIT0071","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1055\/s-2001-14283","article-title":"A comparison of citalopram and paroxetine in the treatment of panic disorder: a randomized, single-blind study","volume":"34","author":"Perna","year":"2001","journal-title":"Pharmacopsychiatry"},{"key":"2021102310543528700_CIT0072","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/npp.2016.170","article-title":"Effects of anodal transcranial direct current stimulation and serotonergic enhancement on memory performance in young and older adults","volume":"42","author":"Prehn","year":"2017","journal-title":"Neuropsychopharmacology"},{"key":"2021102310543528700_CIT0073","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jns.2004.03.007","article-title":"Effects of citalopram on the excitability of the human motor cortex: a paired magnetic stimulation study","volume":"221","author":"Robol","year":"2004","journal-title":"J Neurol Sci"},{"key":"2021102310543528700_CIT0074","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1001\/jamapsychiatry.2017.4040","article-title":"Efficacy and safety of transcranial direct current stimulation as an add-on treatment for bipolar depression: a randomized clinical trial","volume":"75","author":"Sampaio-Junior","year":"2018","journal-title":"JAMA Psychiatry"},{"key":"2021102310543528700_CIT0075","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1101\/lm.6.2.97","article-title":"Memory consolidation for contextual and auditory fear conditioning is dependent on protein synthesis, PKA, and MAP kinase","volume":"6","author":"Schafe","year":"1999","journal-title":"Learn Mem"},{"key":"2021102310543528700_CIT0076","doi-asserted-by":"crossref","first-page":"4988","DOI":"10.1523\/JNEUROSCI.4241-12.2013","article-title":"Serotonin 1A receptors alter expression of movement representations","volume":"33","author":"Scullion","year":"2013","journal-title":"J Neurosci"},{"key":"2021102310543528700_CIT0077","doi-asserted-by":"crossref","first-page":"5202","DOI":"10.1523\/JNEUROSCI.4432-08.2009","article-title":"Polarity-sensitive modulation of cortical neurotransmitters by transcranial stimulation","volume":"29","author":"Stagg","year":"2009","journal-title":"J Neurosci"},{"key":"2021102310543528700_CIT0078","volume-title":"Stahl\u2019s essential psychopharmacology","author":"Stahl","year":"2013","edition":"4"},{"key":"2021102310543528700_CIT0079","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.jad.2012.06.007","article-title":"Selective serotonin reuptake inhibitors and tricyclic antidepressants in the acute treatment of chronic depression and dysthymia: a systematic review and meta-analysis","volume":"144","author":"von Wolff","year":"2013","journal-title":"J Affect Disord"},{"key":"2021102310543528700_CIT0080","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.brs.2014.02.003","article-title":"Variability in response to transcranial direct current stimulation of the motor cortex","volume":"7","author":"Wiethoff","year":"2014","journal-title":"Brain Stimul"},{"key":"2021102310543528700_CIT0081","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/j.clinph.2015.11.012","article-title":"A technical guide to tDCS, and related non-invasive brain stimulation tools","volume":"127","author":"Woods","year":"2016","journal-title":"Clin Neurophysiol"}],"container-title":["International Journal of Neuropsychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ijnp\/advance-article-pdf\/doi\/10.1093\/ijnp\/pyab035\/38864929\/pyab035.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/ijnp\/article-pdf\/24\/10\/787\/40830462\/pyab035.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/ijnp\/article-pdf\/24\/10\/787\/40830462\/pyab035.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T06:46:03Z","timestamp":1672382763000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ijnp\/article\/24\/10\/787\/6295455"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,9]]},"references-count":81,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2021,6,9]]},"published-print":{"date-parts":[[2021,10,23]]}},"URL":"https:\/\/doi.org\/10.1093\/ijnp\/pyab035","relation":{},"ISSN":["1461-1457","1469-5111"],"issn-type":[{"value":"1461-1457","type":"print"},{"value":"1469-5111","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,10,1]]},"published":{"date-parts":[[2021,6,9]]}}}