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In rodent models, exposure to cannabinoids during adolescence leads to increased self-administration of opiates and cocaine, however, the psychological and neural mechanisms and the sex-specificity of this phenomenon are largely unknown.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We exposed male and female adolescent rats to \u03949-tetrahydrocannabinol (THC) and studied at adulthood the effects of such treatment on psychological processes related to reward, such as Pavlovian conditioned approach, Pavlovian to instrumental transfer, habit formation and waiting impulsivity. In the light of these data and given the involvement of the nucleus accumbens in the processes examined, we performed an RNASeq transcriptomic study and assessed cocaine addiction-like behavior.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>THC exposure increased goal-tracking (in males and females) and enhanced Pavlovian to instrumental transfer (especially in males) but did not affect habit formation. THC-exposed rats exhibited subtle, state-dependent changes in premature responding in the 2-CSRTT task. RNASeq data showed gene expression alterations in a marked sex-specific manner. While no effects were found on the acquisition of cocaine self-administration or punished drug-seeking, rats exposed to THC self-administered more cocaine under a progressive ratio schedule (males), had a higher rebound upon returning to continuous access to the drug (females) and showed reduced drug-seeking after 30 days of withdrawal (females).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Adolescent THC affects specific aspects of reward- (and cocaine-) guided behavior and the function of a key brain region mediating these effects, in a remarkable sex-specific manner.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ijnp\/pyab058","type":"journal-article","created":{"date-parts":[[2021,8,26]],"date-time":"2021-08-26T14:01:23Z","timestamp":1629986483000},"page":"920-933","source":"Crossref","is-referenced-by-count":26,"title":["\u0394\u200a9-Tetrahydrocannabinol During Adolescence Reprograms the Nucleus Accumbens Transcriptome, Affecting Reward Processing, Impulsivity, and Specific Aspects of Cocaine Addiction-Like Behavior in a Sex-Dependent Manner"],"prefix":"10.1093","volume":"24","author":[{"given":"Javier","family":"Orihuel","sequence":"first","affiliation":[{"name":"Department of Psychobiology, School of Psychology, National University for Distance Learning (UNED), Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Capell\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Psychobiology, School of Psychology, National University for Distance Learning (UNED), Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Roura-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Department of Psychobiology, School of Psychology, National University for Distance Learning (UNED), Madrid, Spain"},{"name":"Institut de Neurosciences de la Timone, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2786-025X","authenticated-orcid":false,"given":"Marcos","family":"Ucha","sequence":"additional","affiliation":[{"name":"Department of Psychobiology, School of Psychology, National University for Distance Learning (UNED), Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilio","family":"Ambrosio","sequence":"additional","affiliation":[{"name":"Department of Psychobiology, School of Psychology, National University for Distance Learning (UNED), Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Higuera-Matas","sequence":"additional","affiliation":[{"name":"Department of Psychobiology, School of Psychology, National University for Distance Learning (UNED), Madrid, 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