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There is a paucity of pharmacological treatments to reduce core ASD symptoms. Various lines of evidence indicate that reduced brain muscarinic cholinergic receptor activity may contribute to an ASD phenotype.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The present experiments examined whether the partial M1 muscarinic receptor agonist, 5-(3-ethyl-1,2,4-oxadiazol-5-yl)-1,4,5,6-tetrahydropyrimidine hydrochloride (CDD-0102A), alleviates behavioral flexibility deficits and\/or stereotyped motor behaviors in the BTBR mouse model of autism. Behavioral flexibility was tested using a reversal learning test. Stereotyped motor behaviors were measured by eliciting digging behavior after removal of nesting material in a home cage and by measuring repetitive grooming.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>CDD-0102A (0.2 and 0.6 mg\/kg but not 1.2 mg\/kg) injected prior to reversal learning attenuated a deficit in BTBR mice but did not affect performance in B6 mice. Acute CDD-0102A treatment (1.2 and 3 mg\/kg) reduced self-grooming in BTBR mice and reduced digging behavior in B6 and BTBR mice. The M1 muscarinic receptor antagonist VU0255035 (3 mg\/kg) blocked the effect of CDD-0102A on grooming behavior. Chronic treatment with CDD-0102A (1.2 mg\/kg) attenuated self-grooming and digging behavior in BTBR mice. Direct CDD-0102A infusions (1 \u00b5g) into the dorsal striatum reduced elevated digging behavior in BTBR mice. In contrast, CDD-0102A injections in the frontal cortex were not effective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results suggest that treatment with a partial M1 muscarinic receptor agonist may reduce repetitive behaviors and restricted interests in autism in part by stimulating striatal M1 muscarinic receptors.<\/jats:p><\/jats:sec>","DOI":"10.1093\/ijnp\/pyab079","type":"journal-article","created":{"date-parts":[[2021,11,11]],"date-time":"2021-11-11T20:13:48Z","timestamp":1636661628000},"page":"64-74","source":"Crossref","is-referenced-by-count":20,"title":["Effects of the Partial M1 Muscarinic Cholinergic Receptor Agonist CDD-0102A on Stereotyped Motor Behaviors and Reversal Learning in the BTBR Mouse Model of Autism"],"prefix":"10.1093","volume":"25","author":[{"given":"Onella","family":"Athnaiel","sequence":"first","affiliation":[{"name":"Department of Psychology, University of Illinois, Chicago, Illinois, USA"},{"name":"Laboratory of 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