{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T01:04:27Z","timestamp":1789261467633,"version":"build-2803163510"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T00:00:00Z","timestamp":1638748800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["P30234-B27"],"award-info":[{"award-number":["P30234-B27"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["P31564-B30"],"award-info":[{"award-number":["P31564-B30"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"name":"ERA-CVD JTC2020","award":["I04649-B"],"award-info":[{"award-number":["I04649-B"]}]},{"name":"\u00d6sterreichische Muskelforschung","award":["P00845OFF"],"award-info":[{"award-number":["P00845OFF"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,4,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Psilocybin, a hallucinogen contained in \u201cmagic\u201d mushrooms, holds great promise for the treatment of various psychiatric disorders, and early clinical trials are encouraging. Adverse cardiac events after intake of high doses of psilocybin and a trial reporting QT interval prolongation in the electrocardiogram attributed to the drug\u2019s main metabolite, psilocin, gave rise to safety concerns. Here we show that clinical concentrations of psilocin do not cause significant human ether-a-go-go-related gene (hERG) potassium channel inhibition, a major risk factor for adverse cardiac events. We conclude that hERG channel blockage by psilocin is not liable for psilocybin- associated cardiotoxic effects.<\/jats:p>","DOI":"10.1093\/ijnp\/pyab085","type":"journal-article","created":{"date-parts":[[2021,12,3]],"date-time":"2021-12-03T20:11:57Z","timestamp":1638562317000},"page":"280-282","source":"Crossref","is-referenced-by-count":12,"title":["Psilocybin Therapy of Psychiatric Disorders Is Not Hampered by hERG Potassium Channel\u2013Mediated Cardiotoxicity"],"prefix":"10.1093","volume":"25","author":[{"given":"Benjamin","family":"Hackl","sequence":"first","affiliation":[{"name":"Department of Neurophysiology and -Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannes","family":"Todt","sequence":"additional","affiliation":[{"name":"Department of Neurophysiology and -Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helmut","family":"Kubista","sequence":"additional","affiliation":[{"name":"Department of Neurophysiology and -Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karlheinz","family":"Hilber","sequence":"additional","affiliation":[{"name":"Department of Neurophysiology and -Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xaver","family":"Koenig","sequence":"additional","affiliation":[{"name":"Department of Neurophysiology and -Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, 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