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Using the 5-HT 1A receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) as a pharmacological challenge for inducing hypothermia and elevations in plasma corticosterone, males displayed sensitized hypothermal responses after repeated restraint, whereas corticosterone responses to 8-OH-DPAT were enhanced in both sexes following single or repeated exposure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Only males showed elevations in 5-HT 1A receptor G-protein coupling responses in the dorsal raphe after repeated restraint, whereas only females showed an increase in 5-HT 1A receptor responses in the hippocampus following single or repeated exposure. G-protein coupling responses within both regions correlated positively with 5-HT 1A receptor binding capacity. Thus, despite expressing similar capacities for stress HPA axis habituation, males and females emerged from repeated restraint to show region-specific changes in 5-HT 1A receptor function that may be explained, at least in part, by changes in receptor availability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Based on the hypothermal and corticosteroid responses to 8-OH-DPAT, the present data suggest that stress habituation is met by an increase in the sensitivity of presynaptic 5-HT 1A receptors in males and by an increase in the sensitivity of a population of postsynaptic receptors in both sexes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ijnp\/pyac046","type":"journal-article","created":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T08:49:39Z","timestamp":1659084579000},"page":"863-876","source":"Crossref","is-referenced-by-count":18,"title":["Sex Differences in Serotonin 5-HT 1A Receptor Responses to Repeated Restraint Stress in Adult Male and Female Rats"],"prefix":"10.1093","volume":"25","author":[{"given":"Tristan J","family":"Philippe","sequence":"first","affiliation":[{"name":"Department of Cellular and Physiological Sciences, Neuroscience Program, University of British Columbia , Vancouver , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lexia","family":"Bao","sequence":"additional","affiliation":[{"name":"Department of Cellular and Physiological Sciences, Neuroscience Program, University of British Columbia , Vancouver , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maya E","family":"Koblanski","sequence":"additional","affiliation":[{"name":"Department of Cellular and Physiological Sciences, Neuroscience Program, University of British Columbia , Vancouver , 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