{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:09:24Z","timestamp":1790633364490,"version":"4.1.0"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T00:00:00Z","timestamp":1661731200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The prevalence of posttraumatic stress disorder (PTSD) co-occurring in people with bipolar disorder (BD) is high. People with BD and PTSD may experience different outcomes and quality of life after pharmacologic treatment than those with BD alone. This review systematically explores the impact of PTSD on pharmacologic treatment outcomes for adults with BD.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We conducted a systematic search up to November 25, 2021, using MEDLINE Complete, Embase, American Psychological Association PsycInfo, and the Cochrane Central Register of Controlled Trials to identify randomized and nonrandomized studies of pharmacologic interventions for adults with BD that assessed for comorbid PTSD. We used the Newcastle-Ottawa Scale and Cochrane Risk of Bias tool to assess the risk of bias.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The search identified 5093 articles, and we reviewed 62 full-text articles. Two articles met inclusion criteria (N\u2009=\u2009438). One article was an observational study, and the other was a randomized comparative effectiveness trial. The observational study examined lithium response rates and found higher response rates in BD alone compared with BD plus PTSD over 4 years. The randomized trial reported more severe symptoms in the BD plus PTSD group than in those with BD alone following 6 months of quetiapine treatment. There was no significant difference in the lithium treatment group at follow-up.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Comorbid PTSD may affect quetiapine and lithium treatment response in those with BD. Because of the high risk of bias and low quality of evidence, however, these results are preliminary. Specific studies exploring comorbid BD and PTSD are required to inform pharmacotherapy selection and guidelines appropriately. (International Prospective Register of Systematic Reviews ID: CRD42020182540).<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ijnp\/pyac057","type":"journal-article","created":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T21:28:42Z","timestamp":1661808522000},"page":"61-69","source":"Crossref","is-referenced-by-count":9,"title":["The Impact of Posttraumatic Stress Disorder on Pharmacologic Intervention Outcomes for Adults With Bipolar Disorder: A Systematic Review"],"prefix":"10.1093","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6672-7550","authenticated-orcid":false,"given":"Samantha E","family":"Russell","sequence":"first","affiliation":[{"name":"Deakin University, IMPACT, the Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health , Geelong, Victoria , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna L","family":"Wrobel","sequence":"additional","affiliation":[{"name":"Deakin University, IMPACT, the Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health , Geelong, Victoria , Australia"},{"name":"Orygen , Parkville, Victoria , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Skvarc","sequence":"additional","affiliation":[{"name":"Deakin University, IMPACT, the Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health , Geelong, Victoria , Australia"},{"name":"School of Psychology, Faculty of Health, Deakin University , Waurn Ponds, Victoria , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca E","family":"Kavanagh","sequence":"additional","affiliation":[{"name":"Deakin University, IMPACT, the Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health , Geelong, Victoria , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6832-4157","authenticated-orcid":false,"given":"Melanie M","family":"Ashton","sequence":"additional","affiliation":[{"name":"Deakin University, IMPACT, the Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health , Geelong, Victoria , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia M","family":"Dean","sequence":"additional","affiliation":[{"name":"Deakin University, IMPACT, the Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health , Geelong, Victoria , Australia"},{"name":"Florey Institute for Neuroscience and Mental Health, University of Melbourne , Parkville, Victoria , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5554-6946","authenticated-orcid":false,"given":"Michael","family":"Berk","sequence":"additional","affiliation":[{"name":"Deakin University, IMPACT, the Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health , Geelong, Victoria , Australia"},{"name":"Orygen , Parkville, Victoria , Australia"},{"name":"Florey Institute for Neuroscience and Mental Health, University of Melbourne , Parkville, Victoria , Australia"},{"name":"University of Melbourne, Department of Psychiatry, Royal Melbourne Hospital , Parkville, Victoria , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyna","family":"Turner","sequence":"additional","affiliation":[{"name":"Deakin University, IMPACT, the Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health , Geelong, Victoria , Australia"},{"name":"Orygen , Parkville, Victoria , Australia"},{"name":"School of Medicine and Public Health, Faculty of Health, The University of Newcastle , Callaghan, NSW , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,8,29]]},"reference":[{"key":"2023011912400551200_CIT0001","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/pcn.12433","article-title":"Environmental factors, life events, and trauma in the course of bipolar disorder: Clinical course of bipolar disorder","volume":"71","author":"Aldinger","year":"2017","journal-title":"Psychiatry Clin Neurosci"},{"key":"2023011912400551200_CIT0002","doi-asserted-by":"crossref","DOI":"10.1176\/appi.books.9780890425596","volume-title":"Diagnostic and statistical manual of mental disorders","author":"American Psychiatric 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