{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T12:52:58Z","timestamp":1774529578647,"version":"3.50.1"},"reference-count":63,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T00:00:00Z","timestamp":1663286400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071199"],"award-info":[{"award-number":["82071199"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871117"],"award-info":[{"award-number":["81871117"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Cooperative defect is 1 of the earliest manifestations of disease patients with Alzheimer disease (AD) exhibit, but the underlying mechanism remains unclear.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We evaluated the cooperative function of APP\/PS1 transgenic AD model mice at ages 2, 5, and 8 months by using a cooperative drinking task. We examined neuropathologic changes in the medial prefrontal cortex (mPFC). Another experiment was designed to observe whether miconazole, which has a repairing effect on myelin sheath, could promote the cooperative ability of APP\/PS1 mice in the early AD-like stage. We also investigated the protective effects of miconazole on cultured mouse cortical oligodendrocytes exposed to human amyloid \u03b2 peptide (A\u03b21-42).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We observed an age-dependent impairment of cooperative water drinking behavior in APP\/PS1 mice. The AD mice with cooperative dysfunction showed decreases in myelin sheath thickness, oligodendrocyte nuclear heterochromatin percentage, and myelin basic protein expression levels in the mPFC. The cooperative ability was significantly improved in APP\/PS1 mice treated with miconazole. Miconazole treatment increased oligodendrocyte maturation and myelin sheath thickness without reducing A\u03b2 plaque deposition, reactive gliosis, and inflammatory factor levels in the mPFC. Miconazole also protected cultured oligodendrocytes from the toxicity of A\u03b21-42.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>These results demonstrate that mPFC hypomyelination is involved in the cooperative deficits of APP\/PS1 mice. Improving myelination through miconazole therapy may offer a potential therapeutic approach for early intervention in AD.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ijnp\/pyac061","type":"journal-article","created":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T15:51:59Z","timestamp":1663343519000},"page":"951-967","source":"Crossref","is-referenced-by-count":12,"title":["Miconazole Promotes Cooperative Ability of a Mouse Model of Alzheimer Disease"],"prefix":"10.1093","volume":"25","author":[{"given":"Ze","family":"Wang","sequence":"first","affiliation":[{"name":"Jiangsu Province Key Laboratory of Neurodegeneration, Center for Global Health, Nanjing Medical University , Nanjing , China"},{"name":"Brain Institute, the Affiliated Nanjing Brain Hospital of Nanjing Medical University , Nanjing , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanli","family":"Zhang","sequence":"additional","affiliation":[{"name":"Jiangsu Province Key Laboratory of 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