{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:05:43Z","timestamp":1792785943250,"version":"4.5.0"},"reference-count":71,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2022,9,10]],"date-time":"2022-09-10T00:00:00Z","timestamp":1662768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01MH053851"],"award-info":[{"award-number":["R01MH053851"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"name":"US Department of Veterans Affairs Biomedical Laboratory Research and Development Program","award":["I01BX000559"],"award-info":[{"award-number":["I01BX000559"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,12,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Deficits in motor impulsivity, that is, the inability to inhibit a prepotent response, are frequently observed in psychiatric conditions. Several studies suggest that stress often correlates with higher impulsivity. Among the brain areas affected by stress, the orbitofrontal cortex (OFC) is notable because of its role in impulse control. OFC subregions with unique afferent and efferent circuitry play distinct roles in impulse control, yet it is not clear what OFC subregions are engaged during motor impulsivity tasks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this study we used a rodent test of motor impulsivity, the 1-choice serial reaction time test, to explore activation of OFC subregions either during a well-learned motor impulsivity task or in a challenge task with a longer wait time that increases premature responding. We also examined the effects of acute inescapable stress, chronic intermittent cold stress and chronic unpredictable stress on motor impulsivity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fos expression increased in the lateral OFC and agranular insular cortex during performance in both the mastered and challenge conditions. In the ventral OFC, Fos expression increased only during challenge, and within the medial OFC, Fos was not induced in either condition. Inescapable stress produced a transient effect on premature responses in the mastered task, whereas chronic intermittent cold stress and chronic unpredictable stress altered premature responses in both conditions in ways specific to each stressor.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These results suggest that different OFC subregions have different roles in motor impulse control, and the effects of stress vary depending on the nature and duration of the stressor.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ijnp\/pyac062","type":"journal-article","created":{"date-parts":[[2022,9,10]],"date-time":"2022-09-10T12:38:50Z","timestamp":1662813530000},"page":"1026-1036","source":"Crossref","is-referenced-by-count":8,"title":["Role of Orbitofrontal Cortex and Differential Effects of Acute and Chronic Stress on Motor Impulsivity Measured With 1-Choice Serial Reaction Time Test in Male Rats"],"prefix":"10.1093","volume":"25","author":[{"given":"Milena","family":"Girotti","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center at San Antonio , San Antonio, TX , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia R","family":"Carreno","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center at San Antonio , San Antonio, TX , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6689-6258","authenticated-orcid":false,"given":"David A","family":"Morilak","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center at San Antonio , San Antonio, TX , USA"},{"name":"South Texas Veterans 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